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Special Issue Editors

Prof. Dr. Francesca Di Sole

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Guest Editor

Physiology and Pharmacology Department, Des Moines University, Des Moines, IA 50312, USA
Interests: sodium transport; renal diseases; acid-base balanced; adenosine receptor; dopamine receptor; Na+/H+ exchanger; calcium binding protein

Prof. Dr. Maria J. Barnes

E-Mail Website
Guest Editor

Biochemistry and Nutrition Department, Des Moines University, Des Moines, IA 50312, USA
Interests: hypertension; sympathetic activity; gender difference; leptin; central nervous system; post-menoopause

Special Issue Information

Dear Colleagues,

Obesity is a global health burden with associated high health care costs. It correlates with an excess of body fat accumulation that augments physiological changes and enhances the development of diseases such as type 2 diabetes mellitus, hypertension, cardiovascular and kidney diseases. Adipose tissue is in excess in obesity and is a source of hormonally active substances, i.e., the adipokines. Adipokines are a family of cytokines that have a complex set of actions that can be dysregulated in obesity.

The goal of this Special Issue on “Mechanisms of Adipokine Action in Obesity Mediated Metabolic Comorbidities” is to provide recent insights into the role of gender and/or age on release of adipokines and on the adipokines’ effect in the development, improvement and prevention of obesity-mediated metabolic diseases.

The data presented in each article will provide the scientific community with a compilation of recent findings on the impact of gender and/or age on the progression of metabolic diseases in obesity.

Prof. Dr. Francesca Di Sole
Prof. Dr. Maria J. Barnes
Guest Editors

Manuscript Submission Information

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Keywords

adipokines
hypertension
chronic kidney disease
neuro response
inflammation
type 2 diabetes mellitus
insulin resistance
age
gender difference
cardiovascular diseases

Published Papers (2 papers)

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Research

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11 pages, 1577 KiB

Open AccessArticle

Assessing the Causal Effects of Adipokines on Uric Acid and Gout: A Two-Sample Mendelian Randomization Study

by Ruyi Cong, Xiaoyu Zhang, Zihong Song, Shanshan Chen, Guanhua Liu, Yizhi Liu, Xiuyu Pang, Fang Dong, Weijia Xing, Youxin Wang and Xizhu Xu

Nutrients 2022, 14(5), 1091; https://0-doi-org.brum.beds.ac.uk/10.3390/nu14051091 - 05 Mar 2022

Cited by 4 | Viewed by 2707

Abstract

Previous observational studies have highlighted associations between adipokines and hyperuricemia, as well as gout, but the causality and direction of these associations are not clear. Therefore, we attempted to assess whether there are causal effects of specific adipokines (such as adiponectin (ADP) and soluble leptin receptors (sOB-R)) on uric acid (UA) or gout in a two-sample Mendelian randomization (MR) analysis, based on summary statistics from large genome-wide association studies. The inverse-variance weighted (IVW) method was performed as the primary analysis. Sensitivity analyses (including MR-Egger regression, weighted median, penalized weighted median, and MR pleiotropy residual sum and outlier methods) were also performed, to ensure reliable results. In the IVW models, no causal effect was found for sOB-R (odds ratios (OR), 1.002; 95% confidence intervals (CI), 0.999–1.004; p = 0.274) on UA, or ADP (OR, 1.198; 95% CI, 0.865–1.659; p = 0.277) or sOB-R (OR, 0.988; 95% CI, 0.940–1.037; p = 0.616) on gout. The results were confirmed in sensitivity analyses. There was no notable directional pleiotropy or heterogeneity. This study suggests that these specific adipokines may not play causal roles in UA or gout development. Full article

(This article belongs to the Special Issue Mechanisms of Adipokine Action in Obesity Mediated Metabolic Comorbidities)

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Review

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17 pages, 2207 KiB

Open AccessEditor’s ChoiceReview

Pro-Inflammatory Profile of Adipokines in Obesity Contributes to Pathogenesis, Nutritional Disorders, and Cardiovascular Risk in Chronic Kidney Disease

by Sylwia Czaja-Stolc, Marta Potrykus, Marta Stankiewicz, Łukasz Kaska and Sylwia Małgorzewicz

Nutrients 2022, 14(7), 1457; https://0-doi-org.brum.beds.ac.uk/10.3390/nu14071457 - 31 Mar 2022

Cited by 16 | Viewed by 3003

Abstract

Obesity is a disease which leads to the development of many other disorders. Excessive accumulation of lipids in adipose tissue (AT) leads to metabolic changes, including hypertrophy of adipocytes, macrophage migration, changes in the composition of immune cells, and impaired secretion of adipokines. Adipokines are cytokines produced by AT and greatly influence human health. Obesity and the pro-inflammatory profile of adipokines lead to the development of chronic kidney disease (CKD) through different mechanisms. In obesity and adipokine profile, there are gender differences that characterize the male gender as more susceptible to metabolic disorders accompanying obesity, including impaired renal function. The relationship between impaired adipokine secretion and renal disease is two-sided. In the developed CKD, the concentration of adipokines in the serum is additionally disturbed due to their insufficient excretion by the excretory system caused by renal pathology. Increased levels of adipokines affect the nutritional status and cardiovascular risk (CVR) of patients with CKD. This article aims to systematize the current knowledge on the influence of obesity, AT, and adipokine secretion disorders on the pathogenesis of CKD and their influence on nutritional status and CVR in patients with CKD. Full article

(This article belongs to the Special Issue Mechanisms of Adipokine Action in Obesity Mediated Metabolic Comorbidities)

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