Special Issue "Cyclitols in Cardiometabolic Syndrome"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (31 October 2021).

Special Issue Editors

Prof. Dr. Andrzej Rynkiewicz
E-Mail Website
Guest Editor
1st Department of Cardiology and Internal Medicine, School of Medicine, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland
Interests: coronary heart disease; heart failure; arterial hypertension; diabetes mellitus; cardiovascular epidemiology and prevention; nutrition; metabolomics; proteomics; genomics in cardiovascular disorders
Special Issues, Collections and Topics in MDPI journals
Dr. Michal Majewski
E-Mail Website
Guest Editor
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury, Olsztyn, Poland
Interests: copper deficiency; lipid profile; antioxidants; polyphenols

Special Issue Information

Dear Colleagues,

Cyclitols are a group of plant-derived cycloalkanes, containing one hydroxyl group on each of three or more carbons in the ring. In recent years, accumulating evidence from animal and human studies suggested a wide range of pharmaceutical benefits of cyclitol supplementation. Among different compounds, the greatest attention was attracted to inositols, in particular myo-inositol and d-chiro-inositol. As key mediators of cell signal transduction, inositols play a major role in insulin signaling, cell growth, peripheral nerve function, and osteogenesis. In particular, the ability to increase insulin sensitivity was a reason for clinical trials evaluating the use of myo-insoitol and d-chiro-insoitol in polycystic ovary syndrome, type 2 diabetes, and obesity. Simultaneously to improvement in glucose metabolism, inositol supplementation may have a beneficial effect on a variety of metabolic factors, including blood lipids, blood pressure, weight status, and subclinical inflammation.

This Special Issue aims to bring the readers’ attention to the role of cyclitols in cardiometabolic health. We invite research papers focusing on pharmacokinetics, pharmacodynamics, metabolic function of cyclitols, in particular inositols. Additionally, we encourage the submission of reports from clinical trials evaluating the effects of cyclitols supplementation, as well as observational research associating cyclitols with different cardiometabolic outcomes. Last but not least, we also welcome deep narrative and systematic reviews summarizing current evidence on cyclitols and cardiometabolic health.

Prof. Dr. Andrzej Rynkiewicz
Dr. Michal Majewski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Cyclitols
  • Myo-inositol
  • D-chiro-inositol
  • Pinitol
  • Cardiovascular diseases Endothelial function
  • Metabolic syndrome
  • Diabetes
  • Hypertension
  • Dyslipidemia
  • Inflammation

Published Papers

There is no accepted submissions to this special issue at this moment.
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