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Diet and Renal Health Outcomes
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Diet and Renal Health Outcomes

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: closed (30 July 2020) | Viewed by 15724

Special Issue Editor

Dr. Pietro Manuel Ferraro

E-Mail Website
Guest Editor
1. U.O.C. Nefrologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
2. Department of Medicine and Translational Surgery, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
Interests: chronic kidney disease; epidemiology; nephrolithiasis; nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic kidney disease (CKD) is a frequent condition, with an estimated prevalence of about 15%. The proportion of people affected with the condition seems to be increasing over time, a phenomenon that can be at least partly explained by the obesity epidemic and its related burden of chronic diseases, such as diabetes and high blood pressure. Nutritional factors involving the amount and type of nutrients ingested are thought to play a major role in the development and progression of CKD, with an attributable fraction of about 25%. Recently, the focus of research in this field has shifted from the effect of the ingestion of specific macronutrients (particularly protein intake) on renal function to the characterization of the role of different sources of such nutrients (namely, vegetable vs. animal protein). The potential acid/alkaline load conferred by diet as the mediator of its effect on CKD progression is also being actively investigated, as well as the exploration of the effects of certain dietary patterns rather than the intake of individual nutrients. Finally, the interplay between genetics, epigenetics, and the gut microbiome with dietary exposures is another exciting field of research.

The objective of this proposed Special Issue on “Diet and Renal Health Outcomes” is to publish selected papers detailing several aspects of nutrition in chronic kidney disease, including the analysis of dietary patterns leading to CKD development/progression, the effects of the potential acid load on renal function, the relationship between nutrient intakes and risk factors for CKD such as high blood pressure or nephrolithiasis, and the systems biology approach to diet and renal outcomes.

Prof. Pietro Manuel Ferraro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Acid load
  • Albuminuria
  • Alkaline diet
  • Carbohydrates
  • Chronic kidney disease
  • Diet
  • Dietary patterns
  • High blood pressure
  • Lipids
  • Micronutrients
  • Nephrolithiasis
  • Nutrition
  • Protein
  • Vegetables

Published Papers (3 papers)

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Research

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19 pages, 10851 KiB  
Communication
Crescent-Like Lesions as an Early Signature of Nephropathy in a Rat Model of Prediabetes Induced by a Hypercaloric Diet
by Sara Nunes, André Alves, Inês Preguiça, Adelaide Barbosa, Pedro Vieira, Fernando Mendes, Diana Martins, Sofia D. Viana and Flávio Reis
Nutrients 2020, 12(4), 881; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12040881 - 25 Mar 2020
Cited by 14 | Viewed by 3650
Abstract
Diabetic nephropathy (DN) is a major microvascular complication of diabetes. Obesity and hyperlipidemia, fueled by unhealthy food habits, are risk factors to glomerular filtration rate (GFR) decline and DN progression. Several studies recommend that diabetic patients should be screened early (in prediabetes) for [...] Read more.
Diabetic nephropathy (DN) is a major microvascular complication of diabetes. Obesity and hyperlipidemia, fueled by unhealthy food habits, are risk factors to glomerular filtration rate (GFR) decline and DN progression. Several studies recommend that diabetic patients should be screened early (in prediabetes) for kidney disease, in order to prevent advanced stages, for whom the current interventions are clearly inefficient. This ambition greatly depends on the existence of accurate early biomarkers and novel molecular targets, which only may arise with a more thorough knowledge of disease pathophysiology. We used a rat model of prediabetes induced by 23 weeks of high-sugar/high-fat (HSuHF) diet to characterize the phenotype of early renal dysfunction and injury. When compared with the control animals, HSuHF-treated rats displayed a metabolic phenotype compatible with obese prediabetes, displaying impaired glucose tolerance and insulin sensitivity, along with hypertriglyceridemia, and lipid peroxidation. Despite unchanged creatinine levels, the prediabetic animals presented glomerular crescent-like lesions, accompanied by increased kidney Oil-Red-O staining, triglycerides content and mRNA expression of IL-6 and iNOS. This model of HSuHF-induced prediabetes can be a useful tool to study early features of DN, namely crescent-like lesions, an early signature that deserves in-depth elucidation. Full article
(This article belongs to the Special Issue Diet and Renal Health Outcomes)
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Review

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17 pages, 1563 KiB  
Review
Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies
by Vincenzo Losappio, Barbara Infante, Serena Leo, Dario Troise, Martina Calvaruso, Piercarla Vitale, Stefania Renzi, Giovanni Stallone and Giuseppe Castellano
Nutrients 2021, 13(1), 267; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13010267 - 18 Jan 2021
Cited by 10 | Viewed by 4816
Abstract
Access to renal transplantation guarantees a substantial improvement in the clinical condition and quality of life (QoL) for end-stage renal disease (ESRD) patients. In recent years, a greater number of older patients starting renal replacement therapies (RRT) have shown the long-term impact of [...] Read more.
Access to renal transplantation guarantees a substantial improvement in the clinical condition and quality of life (QoL) for end-stage renal disease (ESRD) patients. In recent years, a greater number of older patients starting renal replacement therapies (RRT) have shown the long-term impact of conservative therapies for advanced CKD and the consequences of the uremic milieu, with a frail clinical condition that impacts not only their survival but also limits their access to transplantation. This process, referred to as “inflammaging,” might be reversible with a tailored approach, such as RRT accompanied by specific nutritional support. In this review, we summarize the evidence demonstrating the presence of several proinflammatory substances in the Western diet (WD) and the positive effect of unprocessed food consumption and increased fruit and vegetable intake, suggesting a new approach to reduce inflammaging with the improvement of ESRD clinical status. We conclude that the Mediterranean diet (MD), because of its modulative effects on microbiota and its anti-inflammaging properties, may be a cornerstone in a more precise nutritional support for patients on the waiting list for kidney transplantation. Full article
(This article belongs to the Special Issue Diet and Renal Health Outcomes)
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15 pages, 342 KiB  
Review
Dietary Oxalate Intake and Kidney Outcomes
by Matteo Bargagli, Maria Clarissa Tio, Sushrut S. Waikar and Pietro Manuel Ferraro
Nutrients 2020, 12(9), 2673; https://0-doi-org.brum.beds.ac.uk/10.3390/nu12092673 - 02 Sep 2020
Cited by 33 | Viewed by 6730
Abstract
Oxalate is both a plant-derived molecule and a terminal toxic metabolite with no known physiological function in humans. It is predominantly eliminated by the kidneys through glomerular filtration and tubular secretion. Regardless of the cause, the increased load of dietary oxalate presented to [...] Read more.
Oxalate is both a plant-derived molecule and a terminal toxic metabolite with no known physiological function in humans. It is predominantly eliminated by the kidneys through glomerular filtration and tubular secretion. Regardless of the cause, the increased load of dietary oxalate presented to the kidneys has been linked to different kidney-related conditions and injuries, including calcium oxalate nephrolithiasis, acute and chronic kidney disease. In this paper, we review the current literature on the association between dietary oxalate intake and kidney outcomes. Full article
(This article belongs to the Special Issue Diet and Renal Health Outcomes)
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