Special Issue "Dietary Bioactives: Their Role in the Prevention and Treatment of Cardiovascular and Metabolic Bone Diseases"
Deadline for manuscript submissions: closed (1 November 2021).
Interests: cardiometabolic diseases; inflammation; insulin resistance; endothelial dysfunction; endothelium-derived mediators: nitric oxide, reactive oxygen species, endothelin-1, etc.; osteoporosis and bone demineralization; bone and cartilage differentiation; adult stem cells; innovative cell cultures; dietary bioactive compounds
Special Issues, Collections and Topics in MDPI journals
Interests: cardiovascular dysfunction; osteoporosis and bone demineralization; bone and cartilage differentiation; adult stem cells; innovative cell cultures; dietary bioactive compounds
The constant increase in human life expectancy has significantly influenced the increase in the risk of cardiovascular and metabolic bone diseases, which may be considered as one of the most demanding global health problems.
Numerous approaches have been described to delay and possibly treat cardiometabolic disease and other age-related disorders: one of them takes account of the use of natural molecules and nutritional supplements. An extensive screening of bioactive compounds has been conducted in the last several decades, and a wide range of anti-atherosclerotic activities and osteoprotective effects have been observed, which seem to be mediated via pro-angiogenic, antioxidant, and/or anti-inflammatory pathways leading to osteoblast mineralization and osteoclast inactivation.
In particular, atherosclerotic vascular calcification in cardiovascular disease and loss of bone mineralized matrix in osteoporosis seem to be characterized by common pathophysiological molecular and cellular mechanisms potentially involved in the “bone–vascular cross talk”, which to date remain poorly investigated.
Recent findings have established that several natural compounds have potential promising and significant vascular and bone bioactivities, which may trigger the discovery of new drugs for the management of cardiovascular and metabolic bone diseases.
In this Special Issue, we encourage clinicians and researchers to contribute original research articles, short communications, and review articles that address the biochemical, physiological, and molecular processes underlying the mechanism of action of dietary bioactives in in vitro and in vivo studies related to human nutrition. The submission of studies aimed at characterizing the bioavailability and the biological effect of dietary bioactive metabolites will also be welcomed. Research papers on original products, extracts, and single molecules will be considered.
As Guest Editors, we invite you to contribute to this Special Issue on “Dietary Bioactives: Their Role in the Prevention and Treatment of Cardiovascular and Metabolic Bone Diseases”.
Prof. Assunta Pandolfi
Dr. Domitilla Mandatori
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Dietary bioactive compounds
- Cardiometabolic diseases
- Metabolic bone diseases
- Disease prevention
- Molecular and physiological mechanisms
- Human health and nutrition