Special Issue "Fructose Metabolism and Metabolic Health Effects"
Deadline for manuscript submissions: 25 March 2022.
Interests: obesity;nutrition;insulin resistance;metabolism;lipid metabolism;childhood obesity;carbohydrate metabolism;insulin signaling;metabolic endocrinology;diabetes drug development
There is a worldwide epidemic of obesity, insulin resistance, and metabolic syndrome. Consumption of a high-fat diet was initially proposed to be the driver of the obesity epidemic. As low-fat foods became more popular and in demand, dietary fat was increasingly replaced by another highly palatable food source—refined sugar. However, accumulating evidence suggests that increased sugar consumption may actually be contributing to or driving poor metabolic outcomes associated with obesity.
Renewed interest in sugar metabolism has produced numerous observational studies, linking the intake of dietary sugar with poor metabolic outcomes. In spite of the renewed interest, several questions remain unanswered. First, is dietary sugar simply a vehicle for increased energy intake or is it intrinsically involved in the pathophysiology of obesity? Sugar is generally consumed after meals when subjects are not hungry. Sugar-sweetened beverages are consumed to quench thirst, not hunger. Thus, some suggest that placing a large emphasis on sugar intake is misplaced since increased caloric intake from almost any source will result in obesity. Next, what are the mechanisms linking sugar intake with poor metabolic outcomes? Can we explain on a molecular level why sugar metabolism would negatively affect cellular energy homeostasis? Do different dietary or artificial sugars carry the same metabolic risks? Lastly, can sugar reduction or pharmacologic inhibition of its metabolism serve as a treatment of metabolic dysfunction?
The purpose of this Special Issue is to collect original research reports and review articles that provide the evidence to answer the above questions. Increased understanding of how sugar metabolism affects metabolic outcomes is urgently needed.
Prof. Dr. Samir Softic
Prof. Dr. Miguel A Lanaspa Garcia
Prof. Dr. Brian J. DeBosch
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- insulin resistance
- metabolic syndrome
- chronic inflammation
- nutrient intake
- kidney disease
- intestinal nutrient absorption