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New Insight in Inflammatory Rheumatic Diseases and Nutrition

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A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 15320

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Special Issue Editors

Prof. Dr. Claire Daien

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Guest Editor

Department of Rheumatology, University Hospital of Montpellier, U1046 INSERM - UMR9214 CNRS - UM PhyMedExp Physiologie et Médecine Expérimentale Coeur Muscles, Montpellier, France
Interests: rheumatoid arthritis; inflammatory diseases; gut microbiota; immunity; cardiometabolic comorbidities; dietary interventions

Prof. Dr. Anne Tournadre

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Guest Editor

Department of Rheumatology, University Hospital of Clermont-Ferrand, Human Nutrition Unit, UMR 1019 INRA, University Clermont Auvergne, Clermont-Ferrand, France
Interests: rheumatoid arthritis; spondyloarthritis; myositis; inflammatory diseases; sarcopenia; cardiometabolic comorbidities; dietary interventions; lipotoxicity; omega-3

Prof. Dr. Jérémie Sellam

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Guest Editor

Department of Rheumatology, AP-HP Saint-Antoine hospital, Sorbonne Université Inserm UMRS_938, Paris, France
Interests: arthritis; rheumatoid arthritis; osteoarthritis; inflammation; metabolism; diet; adipokines; pain; obesity

Prof. Dr. Luca Semerano

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Guest Editor

Institut National de la Sante et de la Recherche Medicale (Inserm), UMR 1125, Bobigny, France
Interests: rheumatoid arthritis; autoimmune disease; inflammation; cytokines; autoantibodies; pharmacology

Special Issue Information

Dear Colleagues,

In recent decades, the arrival of biological therapies has revolutionized the management of inflammatory rheumatic diseases. Despite this, comorbidities such as cardiometabolic disorders, fatigue, chronic pain or mood disorders still affect the quality of life of our patients. Beyond the development of new therapeutic targets, personalized medicine constitutes a priority and a challenge to optimize treatment in light of multidisciplinary patient management.

In this context, diet status and nutritional status are key modifiable environmental factors that may be involved in the pathophysiology, and may modulate response to treatment, and clinical outcomes including pain and quality of life and comorbidities. A non-pharmacological approach i.e. diet intervention might also be a way of self-management and empowerment for patients. Gut microbiota and related metabolites could also act as biomarkers and open opportunities for preventive and personalized interventions.

We look forward to your work on the contribution of diet and nutrition in the pathophysiology of inflammatory rheumatic diseases, its place in therapeutic strategies, the management of comorbidities and in the development of a predictive individualized medicine.

We welcome the submission of different types of manuscripts, including original research articles and up-to-date reviews (systematic reviews and meta-analyses).

Potential topics include, but are not limited to, the following:

- Role of diet in inflammatory rheumatic diseases and associated comorbidities

- Role of gut microbiota in inflammatory rheumatic diseases and associated comorbidities

- Personalized nutrition

- Nutrigenomic, metabolomic and lipidomic approach

- Body composition changes

- Possible beneficial effects of bioactive molecule in inflammatory rheumatic diseases.

Prof. Dr. Claire Daien
Prof. Dr. Anne Tournadre
Prof. Dr. Jérémie Sellam
Prof. Dr. Luca Semerano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

diet
microbiota
body composition
probiotic and prebiotic
anti-inflammatory and antioxidant compound
nutrients
rheumatoid arthritis
spondyloarthritis
comorbidities in relation with dietmetabolic syndrome

Published Papers (5 papers)

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Research

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12 pages, 310 KiB

Open AccessArticle

Serum Fatty Acid Profiles Are Associated with Disease Activity in Early Rheumatoid Arthritis: Results from the ESPOIR Cohort

by Johanna Sigaux, Alice Bellicha, Camille Buscail, Chantal Julia, René-Marc Flipo, Alain Cantagrel, Francois Laporte, Caroline Beal, Marie-Christophe Boissier and Luca Semerano

Nutrients 2022, 14(14), 2947; https://0-doi-org.brum.beds.ac.uk/10.3390/nu14142947 - 19 Jul 2022

Cited by 5 | Viewed by 1396

Abstract

Background: Long-chain omega-3 and omega-6 fatty acids (n-3, n-6 FAs) may modulate inflammation and affect the risk of developing rheumatoid arthritis (RA). However, whether n-3/n-6 FA status affects RA after disease onset is unknown. This study aimed to assess whether FA profiles are independently associated with disease activity in a large prospective cohort of patients with early RA. Methods: Baseline serum FAs were quantified in 669 patients in the ESPOIR cohort. Principal component analysis identified three serum FA patterns that were rich in n-7–9, n-3 and n-6 FAs (patterns ω7–9, ω3 and ω6), respectively. The association of pattern tertiles with baseline variables and 6-month disease activity was tested using multivariable logistic regression. Results: Pattern ω3 was associated with low baseline and pattern ω6 with high baseline C-reactive protein level and disease activity. Both patterns ω3 and ω6 were associated with reduced odds of active disease after 6 months of follow-up (pattern ω3: odds ratio, tertile three vs. one, 0.49 [95% CI 0.25 to 0.97] and pattern ω6: 0.51 [0.28 to 0.95]; p = 0.04 and 0.03, respectively). Conclusions: In a cohort of early RA patients, a serum lipid profile rich in n-3 FAs was independently associated with persistently reduced disease activity between baseline and 6-month follow-up. An n-6 FA profile was also associated with lower 6-month disease activity. Full article

(This article belongs to the Special Issue New Insight in Inflammatory Rheumatic Diseases and Nutrition)

11 pages, 1321 KiB

Open AccessArticle

Anthropometric Measures and Risk of Rheumatoid Arthritis in the French E3N Cohort Study

by Carine Salliot, Yann Nguyen, Xavier Mariette, Marie-Christine Boutron-Ruault and Raphaèle Seror

Nutrients 2022, 14(5), 934; https://0-doi-org.brum.beds.ac.uk/10.3390/nu14050934 - 22 Feb 2022

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Abstract

We aimed to assess the relationships between anthropometric measures and risk of rheumatoid arthritis (RA). The E3N cohort included 98,995 women (aged 40–65 years at the recruitment) who completed mailed questionnaires on reproductive factors, lifestyle, and health-related information, including anthropometric measures, every 2–3 years. Cox proportional hazards regression models with age as the time scale and adjusted on known RA risk factors were used to estimate hazard ratios (HRs) and 95% confidence intervals for the risk of incident RA in the overall population (n = 78,452) and after stratification on smoking exposure. Incident RA diagnosis was validated in 698 women. Abdominal obesity (waist circumference >88 cm) was associated with RA (HR = 1.2 (1.0–1.5)), independent of BMI; whereas obesity, defined as BMI ≥ 30 kg/m², was marginally associated with RA (HR = 1.26 (0.9–1.5), ptrend = 0.0559). Taking lean body shape (BS) as reference, medium BS at puberty (HR = 1.3 (1.0–1.7)) and medium-large BS at perimenopausal period (HR = 1.5 (1.1–1.9)) were associated with the risk of RA among never-smoker women, independent of BMI. Regarding BS trajectory, taking constantly lean BS as reference, constantly large BS from puberty to perimenopause was associated with RA among non-smokers (HR = 2.10 (1.2–3.6)), independent of BMI. Full article

(This article belongs to the Special Issue New Insight in Inflammatory Rheumatic Diseases and Nutrition)

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10 pages, 395 KiB

Open AccessArticle

Fish Consumption and Risk of Rheumatoid Arthritis: Findings from the E3N Cohort Study

by Yann Nguyen, Carine Salliot, Xavier Mariette, Marie-Christine Boutron-Ruault and Raphaèle Seror

Nutrients 2022, 14(4), 861; https://0-doi-org.brum.beds.ac.uk/10.3390/nu14040861 - 18 Feb 2022

Cited by 7 | Viewed by 2657

Abstract

Fish consumption has been thought to reduce the risk of rheumatoid arthritis (RA), but the reported data are conflicting. We aimed to assess the association between fish consumption (overall, lean fish, and oily fish) and the risk of RA. The E3N Study is a French prospective cohort study including 98,995 women since 1990. Dietary data were collected via a validated food frequency questionnaire in 1993. Cox proportional hazards models were used to calculate HRs and 95% CIs for incident RA. Models were adjusted for age and for the main potential confounders including cigarette smoking. Among 62,629 women, 480 incident cases of RA were identified. In the overall population, we did not find a linear association between overall fish consumption and RA risk (p for trend 0.65), but a moderate consumption of fish was associated with a decreased risk of RA (HR 0.74; 95% CI 0.59–0.94 for tertile 2 compared with tertile 1), especially among current or former smokers (HR 0.61; 95% CI 0.44–0.85). Although not statistically significant, a trend towards an inverse association was only found with oily fish consumption (HR 0.81; 95% CI 0.65–1.02), but not with lean fish. Our results suggest that moderate fish consumption could reduce the risk or RA and potentially counterbalance the increased risk of RA induced by smoking. This inverse association might be explained by the omega-3 fatty acid content of oily fish. Full article

(This article belongs to the Special Issue New Insight in Inflammatory Rheumatic Diseases and Nutrition)

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12 pages, 881 KiB

Open AccessArticle

Assessment of Intramuscular Fat and Correlation with Body Composition in Patients with Rheumatoid Arthritis and Spondyloarthritis: A Pilot Study

by Marc Villedon de Naide, Bruno Pereira, Daniel Courteix, Frederic Dutheil, Lucie Cassagnes, Yves Boirie, Martin Soubrier and Anne Tournadre

Nutrients 2021, 13(12), 4533; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13124533 - 17 Dec 2021

Cited by 4 | Viewed by 2224

Abstract

Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are associated with changes in body composition. Ectopic intramuscular fat (IMAT) may alter muscle function and contribute to cardiometabolic disorders. In a pilot study, we analyzed IMAT in the calf with peripheral quantitative computed tomography (pQCT) and examined correlations between IMAT quantity and body composition parameters. In 20 patients with active RA and 23 with active SpA, IMAT was correlated with visceral fat (VAT; r = 0.5143 and 0.6314, respectively; p < 0.05) and total lean mass (r = 0.5414 and 0.8132, respectively; p < 0.05), but not with whole body fat mass. Total lean mass mediated 16% and 33% of the effects of VAT on IMAT in RA and SpA, respectively. In both RA and SpA, calf muscle area was correlated with total lean mass (r = 0.5940 and r = 0.8597, respectively; p < 0.05) and fat area was correlated with total body fat (r = 0.6767 and 0.5089, respectively; p < 0.05) and subcutaneous fat (r = 0.6526 and 0.5524, respectively; p < 0.05). Fat area was inversely correlated with handgrip and walking tests, and it was associated with disease activity and disability. We showed that ectopic IMAT, measured with pQCT, was correlated with VAT, but not with total body fat, in RA and SpA. This result suggests that metabolically active fat was specifically associated with IMAT. Full article

(This article belongs to the Special Issue New Insight in Inflammatory Rheumatic Diseases and Nutrition)

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Review

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19 pages, 1878 KiB

Open AccessEditor’s ChoiceReview

Efficacy of Probiotics in Rheumatoid Arthritis and Spondyloarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

by Pauline Sanchez, Jean-Guillaume Letarouilly, Yann Nguyen, Johanna Sigaux, Thomas Barnetche, Sébastien Czernichow, René-Marc Flipo, Jérémie Sellam and Claire Daïen

Nutrients 2022, 14(2), 354; https://0-doi-org.brum.beds.ac.uk/10.3390/nu14020354 - 14 Jan 2022

Cited by 17 | Viewed by 6695

Abstract

Background: We aimed to provide a systematic review and meta-analysis of randomized controlled trials assessing the effect of probiotics supplementation on symptoms and disease activity in patients with chronic inflammatory rheumatic diseases (rheumatoid arthritis (RA), spondylarthritis (SpA), or psoriatic arthritis). Methods: A systematic literature review and meta-analysis from RA and SpA randomized controlled trials were conducted searching for articles in MEDLINE/PubMed and abstracts from recent international rheumatology meetings. The control group was a placebo or another dietary intervention. The risk of bias of the selected studies was evaluated using the Cochrane Collaboration tool and the Jadad scale. Results: The initial search yielded 173 articles. Of these, 13 studies were included in the qualitative synthesis, 8 concerning a total of 344 RA patients and 2 concerning a total of 197 SpA patients. Three meta-analyses were also analyzed. Probiotic strains and quantities used were different among trials (5 studies using Lactobacillus sp., 1 trial Bacillus coagulans and the others a mix of different probiotic strains). Time to assess response ranged from 8 weeks to one year. Two studies associated probiotic supplementation with a dietary intervention. Meta-analysis showed a statistically significant decrease of C-reactive protein (CRP) concentration (mean difference (MD)) −3.04 (95% CI −4.47, −1.62) mg/L, p < 0.001; I² = 20%, n patients = 209) with probiotics in RA. However, after excluding high-risk-of-bias trials of meta-analysis, there was no difference between probiotics and placebo on DAS28 (standard MD −0.54; 95% CI −1.94 to 0.85, p = 0.45, I² 93%, n patients = 143). The two studies on SpA patients showed no efficacy of probiotics. Conclusions: Probiotic supplementation might decrease RA activity with a moderate decrease effect on CRP, but lack of evidence and studies’ heterogeneity do not allow us to propose them to patients with inflammatory arthritis to control their disease. Further RCTs are required in the future to determinate the efficacy of probiotics and the optimal administration design. Full article

(This article belongs to the Special Issue New Insight in Inflammatory Rheumatic Diseases and Nutrition)

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