Special Issue "Mendelian Randomization Studies on Nutritional Factors and Health Outcomes"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 10 March 2022.

Special Issue Editor

Dr. Susanna C. Larsson
E-Mail Website
Guest Editor
Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden
Interests: diet; lifestyle; modifiable risk factors; stroke; cardiovascular disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Poor diet is a leading cause of morbidity and mortality. However, the causal role of specific foods, nutrients, and other dietary compounds in health and disease is not fully established, as most evidence derives from traditional observational studies. Such studies are susceptible to residual confounding, reverse causation bias, and misclassification of dietary intake. Mendelian randomization is a method that can reduce such biases in observational studies and provide more robust evidence concerning the role of dietary factors in health and disease.

The present Special Issue aims to add research knowledge from Mendelian randomization studies on nutritional factors in relation to health outcomes, including diseases and risk factors (e.g., hypertension, elevated blood lipids, and adiposity) that may mediate the diet–disease associations. This issue welcomes original and review articles reporting results from Mendelian randomization studies.

Dr. Susanna C. Larsson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mendelian randomization
  • single nucleotide polymorphisms
  • beverages
  • foods
  • nutrients
  • vitamins
  • minerals
  • fatty acids

Published Papers (1 paper)

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Research

Article
Genetically Predicted Milk Intake and Risk of Neurodegenerative Diseases
Nutrients 2021, 13(8), 2893; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13082893 - 23 Aug 2021
Viewed by 934
Abstract
Milk intake has been associated with risk of neurodegenerative diseases in observational studies. Nevertheless, whether the association is causal remains unknown. We adopted Mendelian randomization design to evaluate the potential causal association between milk intake and common neurodegenerative diseases, including multiple sclerosis (MS), [...] Read more.
Milk intake has been associated with risk of neurodegenerative diseases in observational studies. Nevertheless, whether the association is causal remains unknown. We adopted Mendelian randomization design to evaluate the potential causal association between milk intake and common neurodegenerative diseases, including multiple sclerosis (MS), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD). Genetic associations for neurodegenerative diseases were obtained from the International Multiple Sclerosis Genetics Consortium (n = 80,094), FinnGen consortium (n = 176,899), AD GWAS (n = 63,926), Web-Based Study of Parkinson’s Disease (n = 308,518), PDGene (n = 108,990), and ALS GWAS (n = 80,610). Lactase persistence variant rs4988235 (LCT-13910 C > T) was used as the instrumental variable for milk intake. Genetically predicted higher milk intake was associated with a decreased risk of MS and AD and with an increased risk of PD. For each additional milk intake increasing allele, the odds ratios were 0.94 (95% confidence intervals [CI]: 0.91–0.97; p = 1.51 × 10−4) for MS, 0.97 (0.94–0.99; p = 0.019) for AD and 1.09 (95%CI: 1.06–1.12, p = 9.30 × 10−9) for PD. Genetically predicted milk intake was not associated with ALS (odds ratio: 0.97, 95%CI: 0.94–1.01, p = 0.135). Our results suggest that genetically predicted milk intake is associated with a decreased risk of MS and AD but with an increased risk of PD. Further investigations are needed to clarify the underlying mechanisms. Full article
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