Special Issue "Frontier: Diet, Mitochondrial Function and Dysfunction"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 21 January 2022.

Special Issue Editors

Prof. Dr. Joseph Vamecq
Guest Editor
Inserm, Biochemistry and Molecular Biology Laboratory , HMNO, CBP, CHRU Lille & EA 7364 – RADEME, North France University Lille, 59000 Lille, France
Interests: mitochondria; liver injury; olive oils; anti-inflammatory
Prof. Dr. Mustapha Cherkaoui-Malki
Co-Guest Editor
Laboratoire BioPeroxIL (Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique) EA 7270, Université de Bourgogne-Franche Comté, Dijon F-21000, France
Interests: mitochondria; liver injury; Mediterranean diet; antioxidant

Special Issue Information

Dear Colleagues,

Mitochondria have gained in interest in recent years. For example, in addition to their role in apoptotic cell death, their remarkable plasticity to serve as a cellular metabolic platform in the development of cancer cells has been demonstrated and represents a potential current target for cancer therapy. Mitochondria actually represent an intracellular organelle network encompassing metabolic, energetic, heating, redox and signaling activities. Mitochondrial metabolic enzymes are coupled to OXPHOS complexes for energy production, and, in concert with protein counterparts from other subcellular sites, regulate cell metabolic (NADH+H+/NAD+ ratio) and antioxidant (reduced to oxidized glutathione) redox states. Mitochondria may yield heat by uncoupling and ATP hydrolysis; and regulate calcium signaling and iron metabolism. Mitochondria are a site for apoptosis and contain receptors for vitamins (vitamin D). Therefore, diet may impact mitochondrial function and hence dysfunction via supply in and modulation by energetic substrates, vitamins, antioxidants and vegetal oil compounds.

The aim of this Special Issue is to update knowledge and report innovative studies on:

  • Modulating mitochondrial function and dysfunction by dietary compounds;
  • Designing anaplerosis strategies based on small energetic substrates (lactate, ketones, short/medium-chain fatty acids and esters) in patients with mitochondrial disorders;
  • Documenting links between mitochondria, inflammation and diet;
  • Proposing any well-founded experimental or hypothetical insights in mitochondrial functions;
  • Mitochondrial antioxidant redox control in age-related diseases.

We welcome both original research articles and up-to-date reviews (systematic reviews and meta-analyses).

Prof. Dr. Joseph Vamecq
Prof. Dr. Mustapha Cherkaoui-Malki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • diet manipulations
  • vegetal oils and antioxidants
  • mitochondrial function and dysfunction
  • energy and heat production
  • cataplerosis and anaplerosis strategies
  • small energetic substrates
  • lactate
  • ketone bodies
  • dietary uncouplers
  • metabolic redox status
  • antioxidant status
  • age-related diseases

Published Papers

This special issue is now open for submission.
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