Special Issue "Dietary Interventions To Alter Microbiome in Pregnancy"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrigenetics and Nutrigenomics".

Deadline for manuscript submissions: closed (31 July 2021).

Special Issue Editor

Dr. Marloes Dekker Nitert
E-Mail Website
Guest Editor
School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia
Interests: microbiome; pregnancy; obesity; hypertension, diabetes

Special Issue Information

Dear Colleagues,

The incidence of obesity and gestational diabetes is increasing across the world, affecting the health of mother and baby during pregnancy and putting both at risk for future (cardio)metabolic disease. A plethora of strategies to prevent and/or decrease the consequences of obesity and gestational diabetes have been investigated including dietary and exercise interventions with varying levels of success. The discovery of the large changes to the composition of the gut microbiota in pregnancy sparked an interest in the scientific community to investigate if manipulation of the gut microbiota by dietary interventions including pre- and probiotics would be a new strategy to prevent complications of pregnancy such as gestational diabetes and preeclampsia.  

In this special issue of Nutrients, we welcome contributions that investigate dietary interventions that are aimed to prevent or treat pregnancy complications through targeting the microbiome in humans or animal models. Furthermore, studies that investigate the mechanisms by which these interventions act are welcomed as this still is an area that is poorly understood.

Dr. Marloes Dekker Nitert
Guest Editor


Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Pregnancy
  • Gestational diabetes mellitus
  • Microbiome
  • Preeclampsia
  • Pro/Prebiotics
  • Prevention
  • Dietary intake

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Review
Diet and Pre-Intervention Washout Modifies the Effects of Probiotics on Gestational Diabetes Mellitus: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients 2021, 13(9), 3045; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093045 - 30 Aug 2021
Viewed by 1339
Abstract
Dynamic interactions among gestational diabetes mellitus (GDM), gut microbiota, inflammation, oxidative stress, and probiotics are increasingly acknowledged. This meta-analysis aimed to summarize the effects of probiotics in GDM, focusing on lifestyle intervention and pre-intervention washout, in addition to metabolic, inflammation, oxidative stress, and [...] Read more.
Dynamic interactions among gestational diabetes mellitus (GDM), gut microbiota, inflammation, oxidative stress, and probiotics are increasingly acknowledged. This meta-analysis aimed to summarize the effects of probiotics in GDM, focusing on lifestyle intervention and pre-intervention washout, in addition to metabolic, inflammation, oxidative stress, and pregnancy outcomes. Three electronic databases (i.e., PubMed, Scopus, and CENTRAL) were searched from inception until October 2020. A meta-analysis was performed, and the effect sizes were reported as either mean differences or odds ratios with 95% confidence intervals. Altogether, 10 randomized controlled trials enrolling 594 participants were included. The meta-analysis indicated that probiotics supplementation effectively reduced fasting plasma glucose by 3.10 mg/dL, and subgroup analyses suggested that the duration of intervention, number of species, pre-intervention washout period, and dietary intervention may determine the effects of probiotics. Probiotics also reduced the level of inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-α, and malondialdehyde), incidence of macrosomia, and newborn hospitalization. In conclusion, this meta-analysis suggests that probiotics may have positive effects on metabolic, inflammation, oxidative stress, and neonatal outcomes in women with GDM. Additionally, diet and pre-intervention washout may modify the effects of probiotics. Future studies are warranted on a larger scale to ascertain the clinical significance. Full article
(This article belongs to the Special Issue Dietary Interventions To Alter Microbiome in Pregnancy)
Show Figures

Figure 1

Back to TopTop