Special Issue "Feature Papers in Organics"
A special issue of Organics (ISSN 2673-401X).
Deadline for manuscript submissions: 31 October 2021.
Interests: organic chemistry; heterocyclic chemistry; supramolecular chemistry
Special Issues, Collections and Topics in MDPI journals
Topical Collection in Molecules: Heterocyclic Compounds
Interests: amide bonds; N-heterocyclic carbenes; C-N activation; C-H activation; C-O activation; lanthanides; cross-coupling; catalysis; reductions; reductive couplings; radical chemistry; synthetic methodology; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue in Molecules: Advances in Organometallic Chemistry—Papers of the Editorial Board Members (EBMs)
Special Issue in Molecules: Amide Bond Activation II
Special Issue in International Journal of Molecular Sciences: Sulfonamides as a Potent Anti-cancer Agents
We are glad to announce the Special Issue entitled "Feature Papers in Organics". It is open to receiving high-quality papers which will be published, free of charge, in Open Access form after peer review. We welcome the submission of manuscripts from Editorial Board Members and from outstanding scholars invited by the Academic Editors and the Editorial Office. We are flexible with the types of manuscript accepted, including original research articles, short communications, highlights of new developments, and insightful critical reviews. Detailed experimental procedures are required for research articles and communications.
As you see in the keywords list, sample research topics included in this Special Issue represent the whole journal. This is intended to open more chances for submissions related to organic chemistry around the world.
Prof. Dr. Wim Dehaen
Prof. Dr. Michal Szostak
Prof. Dr. Huaping Xu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Organics is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Organic synthesis
- Development of synthetic methodology
- Theoretical organic chemistry
- Physical organic chemistry
- Supramolecular and macromolecular chemistry
- Heterocyclic chemistry
- Bioorganic chemistry
- Organometallic chemistry
- Functional organic materials
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: SYNTHESIS OF NOVEL PYRAZOLOPYRIDINES WITH AFFINITY FOR β-AMYLOID PLAQUES AND FIBRILS
Authors: Vidali, V.P 1,*; Georgia Nigianni 1,2; Aleksander Canko 1; Varvara Mavroidi 2; Dimitris Matiadis 2,*; Marina Sagnou 2
Affiliation: 1 NCSR "Demokritos", Institute of Nanoscience & Nanotechnology, Patr. Grigoriou & Neapoleos 27, Athens, 153 41, Greece 2 NCSR "Demokritos", Institute of Biosciences & Applications, Patr. Grigoriou & Neapoleos 27, Athens, 153 41, Greece
Abstract: Pyrazole-containing fused heterocyclic systems are ranked among the most versatile bioactive compounds, and a variety of procedures have been developed for their synthesis. In particular, pyrazolo[3,4-b]pyridines constitute a group of fused heterocyclic systems with outstanding chemical, biological and medicinal significance. More specifically, this privileged scaffold is the main structural component of clinically used drugs against Alzheimer’s disease. To this end, a small library of pyrazolo[3,4-b]pyridines was prepared by reacting the 1-phenyl-1H-pyrazol-5-amine with various α,β-unsaturated ketones in the presence of ZrCl4. The desired ketones were afforded from various aldehydes via a Claisen-Schmidt condensation reaction with acetone or via a Wittig reaction with 1-triphenylphosphoranylidene-2-propanone. The novel pyrazolopyridines were evaluated for their affinity for amyloid plaques by means of fluorescence microscopy fluorescence images of consecutive brain slices from autopsy confirmed AD patient. Among them, the highly fluorescent dimethylamine-bearing derivative was able to selectively stain the amyloid plaques. Moreover, the thioflavin T (ThT) fluorescence test that detects mature Aβ fibrils, revealed that the vanillin containing pyrazolopyridine interfered significantly with the rate of Aβ fibrilisation. Overall our results strongly support the high potential of the privileged pyrazolo[3,4-b]pyridine scaffold as an AD diagnostic or therapeutic agent.
Title: BORANILS: Versatile Multifunctional Organic Fluorophores for Innovative Applications
Authors: Julien Massue 1; Denis Jacquemin 2; Gilles Ulrich 1
Affiliation: 1 ICPEES, CNRS-UMR7515, Université de Strasbourg, France 2 CEISAM Lab-UMR 6230-CNRS & University of Nantes, 2 Rue de la Houssinière, 44322 Nantes, France
Abstract: Multifunctional stimuli-responsive fluorophores with bright, environment-sensitive fluorescence emissions have fueled intense research for their innovative applications in the field of biotechnologies, optoelectronics and materials. A strong structural diversity is observed among smart molecular materials, which has been enriched over the years with a growing responsiveness to stimuli. Boron dipyrromethene (BODIPY) dyes have long been the flagship of boron complexes due to their outstanding properties until a decade ago when analogues based on N^O, N^N or N^C π-conjugated chelates have emerged. The finality of developing alternates borate dyes was to compensate for BODIPYs’ lack of solid-state fluorescence and weak Stokes shifts while keeping their excellent optical properties in solution. Among them, the borate complexes based on an aniline-imine or salicylaldimine ligand, called by the acronym BORANILS appear as ones of the most promising, owing to their facile scalable synthesis and fine-tunable dual-state emission properties. Over the years, BORANIL dyes have proven to be good alternatives to BODIPY dyes and have been successfully applied in diverse but innovative applications such as aggregation-induced emission, room-temperature phosphorescence, mecanochemistry, bioimaging, bioconjugation and detection of biosubstrates or pollutants. Meanwhile, ab initio calculations have rationalized experimental results and provided insightful feedback for future designs. This review article aims at providing a concise but complete overview of the chemistry around the BORANIL core with the subsequent applications of the functionalized dyes. Theoretical aspects will also be discussed.