Special Issue Information

Dear Colleagues,

This Special Issue is devoted to presenting new trends of platelet rich plasma (PRP) and mesenchymal stem cell (MSC) application in musculoskeletal disorders with regard to basic mechanisms and also histopathological, radiological, and clinical implications. Our understanding of PRP and MSC application on microscopic tissue alterations is still insufficient, and it may be the key to gaining knowledge about the complete recovery of musculoskeletal diseases. Likewise, an increasing number of studies have revealed functional improvements after this therapy. However, histopathological and radiological implications are usually deficiently presented. Thus, there is a need for continued progress in PRP and MSC research, validation of PRP and MSC preparation protocols, and correlation with histopathological changes in musculoskeletal pathologies.

Finally, all papers on novel clinical applications of PRP and MSCs, also in combination with other bioactive molecules, in the treatment of musculoskeletal disorders are welcome, as are basic science and radiological studies.

Dr. Jan Zabrzyński
Prof. Dr. Gazi Huri
Prof. Dr. Maciej Gagat
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Osteology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

PRP
tendinopathy
rotator cuff
orthobiology
inflammation
therapy

Published Papers (2 papers)

Download All Papers

Review

16 pages, 2157 KiB

Open AccessReview

Immunomodulatory Actions of Mesenchymal Stromal Cells (MSCs) in Osteoarthritis of the Knee

by Gangireddi Suresh Babu, Yelisetty Badrish, Vinit M Oswal, Naveen Jeyaraman, Gollahalli Shivashankar Prajwal, Madhan Jeyaraman, Sathish Muthu and Manish Khanna

Osteology 2021, 1(4), 209-224; https://0-doi-org.brum.beds.ac.uk/10.3390/osteology1040020 - 17 Nov 2021

Cited by 8 | Viewed by 3277

Abstract

Cellular therapy offers regeneration which curbs osteoarthritis of the knee. Among cellular therapies, mesenchymal stromal cells (MSCs) are readily isolated from various sources as culture expanded and unexpanded cellular population which are used as therapeutic products. Though MSCs possess a unique immunological and regulatory profile through cross-talk between MSCs and immunoregulatory cells (T cells, NK cells, dendritic cells, B cells, neutrophils, monocytes, and macrophages), they provide an immunotolerant environment when transplanted to the site of action. Immunophenotypic profile allows MSCs to escape immune surveillance and promotes their hypoimmunogenic or immune-privileged status. MSCs do not elicit a proliferative response when co-cultured with allogeneic T cells in vitro. MSCs secrete a wide range of anti-inflammatory mediators such as PGE-2, IDO, IL-1Ra, and IL-10. They also stimulate the resilient chondrogenic progenitors and enhance the chondrocyte differentiation by secretion of BMPs and TGFβ1. We highlight the various mechanisms of MSCs during tissue healing signals, their interaction with the immune system, and the impact of their lifespan in the management of osteoarthritis of the knee. A better understanding of the immunobiology of MSC renders them as an efficient therapeutic product for the management of osteoarthritis of the knee. Full article

(This article belongs to the Special Issue Platelet Rich Plasma and Mesenchymal Stem Cells in Orthobiologics Therapy – From Basic Science to Clinical Application)

► Show Figures

Figure 1

27 pages, 1922 KiB

Open AccessFeature PaperReview

Chondrogenic Potential of Dental-Derived Mesenchymal Stromal Cells

by Naveen Jeyaraman, Gollahalli Shivashankar Prajwal, Madhan Jeyaraman, Sathish Muthu and Manish Khanna

Osteology 2021, 1(3), 149-174; https://0-doi-org.brum.beds.ac.uk/10.3390/osteology1030016 - 15 Sep 2021

Cited by 2 | Viewed by 3536

Abstract

The field of tissue engineering has revolutionized the world in organ and tissue regeneration. With the robust research among regenerative medicine experts and researchers, the plausibility of regenerating cartilage has come into the limelight. For cartilage tissue engineering, orthopedic surgeons and orthobiologists use the mesenchymal stromal cells (MSCs) of various origins along with the cytokines, growth factors, and scaffolds. The least utilized MSCs are of dental origin, which are the richest sources of stromal and progenitor cells. There is a paradigm shift towards the utilization of dental source MSCs in chondrogenesis and cartilage regeneration. Dental-derived MSCs possess similar phenotypes and genotypes like other sources of MSCs along with specific markers such as dentin matrix acidic phosphoprotein (DMP) -1, dentin sialophosphoprotein (DSPP), alkaline phosphatase (ALP), osteopontin (OPN), bone sialoprotein (BSP), and STRO-1. Concerning chondrogenicity, there is literature with marginal use of dental-derived MSCs. Various studies provide evidence for in-vitro and in-vivo chondrogenesis by dental-derived MSCs. With such evidence, clinical trials must be taken up to support or refute the evidence for regenerating cartilage tissues by dental-derived MSCs. This article highlights the significance of dental-derived MSCs for cartilage tissue regeneration. Full article

(This article belongs to the Special Issue Platelet Rich Plasma and Mesenchymal Stem Cells in Orthobiologics Therapy – From Basic Science to Clinical Application)

► Show Figures

Figure 1

Journal Menu

Journal Browser

Platelet Rich Plasma and Mesenchymal Stem Cells in Orthobiologics Therapy – From Basic Science to Clinical Application

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Published Papers (2 papers)

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI