COVID-19 in Low and Middle Income Countries

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 29235

Special Issue Editors


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Guest Editor
Global Health Institute, University of Antwerp, Antwerp, Belgium
Interests: onchocerciasis; epilepsy; epidemiology; public health; infectious and tropical diseases
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Guest Editor
Laboratory of Embryology & Biotechnology, Université Libre de Bruxelles, Gosselies, Belgium
Interests: onchocerciasis; parasite biology; nematodes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The COVID-19 pandemic is expected to increasingly spread in low and middle income countries (LMIC). In the absence of effective treatments or vaccines, the WHO strongly recommends that countries implement interventions to curb the rapid spread of COVID-19, through minimizing contact between infected and uninfected persons. Suggested measures include lockdowns, closing schools and public places, prohibition of social gatherings, and stringent personal methods of physical distancing, wearing face masks and hand hygiene.

Most governments in LMICs, in an early phase of the epidemic, have implemented lockdown measurements. Such interventions were typically modelled on the COVID-19 outbreaks in high-income countries. Concerns have, however, been raised that the pandemic follows very different trajectories in different contexts, and that a “one size fits all” approach for non-pharmaceutical interventions may not be appropriate, as the risk–benefit balance of such interventions may be very different in different settings. Although the early implementation of lockdown measures for COVID-19 control may have contributed to the (initially) low mortality observed in several LMICs, the collateral damage resulting from this strategy is becoming increasingly apparent. Moreover, lockdown measures are more detrimental to those with the least resources.

Since many LMIC countries are now easing lockdown measures, the number of COVID-19 cases is likely to increase rapidly. We have already learnt a lot about COVID-19, but there are still many unknowns: the one constant feature of the COVID-19 pandemic is its unpredictability. The main operational as well as research question for LMIC is how to reduce COVID-19 transmission and COVID-related mortality, with minimal collateral damage to the economy, the wellbeing of people, and the prevention and control of other diseases.

With this Special Issue, we hope to learn from LMICs, to identify the most effective combination of measures to reduce the incidence of severe COVID-19 disease. We invite you to submit research articles, review articles, short notes about the epidemiology of COVID-19 in LMICs, innovative ways to prevent and treat COVID-19 infection in settings with limited resources, adherence to preventive measures, the impact of COVID-19 on both the physiological and psychological wellbeing of people and the health system, host–pathogen interactions, COVID-19 diagnostics, host immune responses, and vaccine development.

The “COVID-19 in Low and Middle Income Countries” Special Issue is jointly organized between “Pathogens” and “International Journal of Environmental Research and Public Health” journals. You may choose our Joint Special Issue in International Journal of Environmental Research and Public Health.

We look forward to your contribution.

References

  1. El-Sadr, W.M.; Justman, J. Africa in the Path of Covid-19. N. Engl. J. Med. 2020, 383, e11.
  2. Siewe Fodjo, J. N.; Pengpid, S.; Villela, E.; Van Thang, V.; Ahmed, M.; Ditekemena, J.; Crespo, B.V.; Wanyenze, R.K.; Dula, J.; Watanabe, T.; et al. Mass masking as a way to contain COVID-19 and exit lockdown in low- and middle income countries. J. Infect. 2020, S0163-4453(20)30489-8.
  3. Nepomnyashchiy, L.; Dahn, B.; Saykpah, R.; Raghavan, M. COVID-19: Africa needs unprecedented attention to strengthen community health systems. Lancet 2020, 396, 150–152.
  4. Mutesa, L.; Ndishimye, P.; Butera, Y.; Souopgui, J.; Uwineza, A.; Rutayisire, R.; Musoni, E.; Rujeni, N.; Nyatanyi, T.; Ntagwabira, E.; et al. A strategy for finding people infected with SARS-CoV-2: optimizing pooled testing at low prevalence. Nature, 2020, (2020-05-08724, Under revision - http://arxiv.org/abs/2004.14934)

Prof. Dr. Robert Colebunders
Prof. Dr. Jacob Souopgui
Guest Editors

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Keywords

  • COVID-19
  • epidemiology
  • prevention
  • diagnosis
  • treatment
  • pathogenesis
  • immunology
  • low and middle income countries

Related Special Issue

Published Papers (6 papers)

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Editorial

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3 pages, 206 KiB  
Editorial
COVID-19 in Low and Middle Income Countries
by Robert Colebunders and Joseph Nelson Siewe Fodjo
Pathogens 2022, 11(11), 1325; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens11111325 - 11 Nov 2022
Cited by 2 | Viewed by 831
Abstract
The COVID-19 pandemic is by far the worst epidemic in the last century, causing more than 6 [...] Full article
(This article belongs to the Special Issue COVID-19 in Low and Middle Income Countries)

Research

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12 pages, 1387 KiB  
Article
Molecular Analysis of SARS-CoV-2 Genetic Lineages in Jordan: Tracking the Introduction and Spread of COVID-19 UK Variant of Concern at a Country Level
by Malik Sallam and Azmi Mahafzah
Pathogens 2021, 10(3), 302; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens10030302 - 05 Mar 2021
Cited by 13 | Viewed by 4087
Abstract
The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is manifested by the emergence of an ever-growing pool of genetic lineages. The aim of this study was to analyze the genetic variability of SARS-CoV-2 in Jordan, with a special focus on [...] Read more.
The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is manifested by the emergence of an ever-growing pool of genetic lineages. The aim of this study was to analyze the genetic variability of SARS-CoV-2 in Jordan, with a special focus on the UK variant of concern. A total of 579 SARS-CoV-2 sequences collected in Jordan were subjected to maximum likelihood and Bayesian phylogenetic analysis. Genetic lineage assignment was undertaken using the Pango system. Amino acid substitutions were investigated using the Protein Variation Effect Analyzer (PROVEAN) tool. A total of 19 different SARS-CoV-2 genetic lineages were detected, with the most frequent being the first Jordan lineage (B.1.1.312), first detected in August 2020 (n = 424, 73.2%). This was followed by the second Jordan lineage (B.1.36.10), first detected in September 2020 (n = 62, 10.7%), and the UK variant of concern (B.1.1.7; n = 36, 6.2%). In the spike gene region, the molecular signature for B.1.1.312 was the non-synonymous mutation A24432T resulting in a deleterious amino acid substitution (Q957L), while the molecular signature for B.1.36.10 was the synonymous mutation C22444T. Bayesian analysis revealed that the UK variant of concern (B.1.1.7) was introduced into Jordan in late November 2020 (mean estimate); four weeks earlier than its official reporting in the country. In Jordan, an exponential increase in COVID-19 cases due to B.1.1.7 lineage coincided with the new year 2021. The highest proportion of phylogenetic clustering was detected for the B.1.1.7 lineage. The amino acid substitution D614G in the spike glycoprotein was exclusively present in the country from July 2020 onwards. Two Jordanian lineages dominated infections in the country, with continuous introduction/emergence of new lineages. In Jordan, the rapid spread of the UK variant of concern should be monitored closely. The spread of SARS-CoV-2 mutants appeared to be related to the founder effect; nevertheless, the biological impact of certain mutations should be further investigated. Full article
(This article belongs to the Special Issue COVID-19 in Low and Middle Income Countries)
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11 pages, 380 KiB  
Article
Estimating the Percentage of a Population Infected with SARS-CoV-2 Using the Number of Reported Deaths: A Policy Planning Tool
by Daniel R. Feikin, Marc-Alain Widdowson and Kim Mulholland
Pathogens 2020, 9(10), 838; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens9100838 - 13 Oct 2020
Cited by 4 | Viewed by 2514
Abstract
The magnitude of future waves of Covid19 in a population will depend, in part, on the percentage of that population already infected, recovered, and presumably immune. Sero-epidemiological surveys can define the prevalence of SARS-CoV-2 antibodies in various populations. However, sero-surveys are resource-intensive and [...] Read more.
The magnitude of future waves of Covid19 in a population will depend, in part, on the percentage of that population already infected, recovered, and presumably immune. Sero-epidemiological surveys can define the prevalence of SARS-CoV-2 antibodies in various populations. However, sero-surveys are resource-intensive and methodologically challenging, limiting widespread use. We propose a relatively simple method for calculating the percentage of a population infected, which depends on the number of reported Covid19 deaths, a figure usually more reliable and less dependent on variable testing practices than the total number of reported Covid19 cases, and the infection fatality rate, a figure that is relatively stable in similar populations. The method can be applied in different sized areas, such as states, districts, or cities. Such an approach can provide useful, real-time estimates of probable population immunity in settings unable to undertake multiple sero-surveys. This method is applicable to low- and lower-middle-income country (LMIC) settings where sero-survey data will likely be limited; however, better estimates of infection fatality rates and Covid19 death counts in LMICs are needed to improve the method’s accuracy. Information on the percentage of a population infected will help public health authorities in planning for future waves of Covid19, including where to most effectively deploy vaccines. Full article
(This article belongs to the Special Issue COVID-19 in Low and Middle Income Countries)
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11 pages, 1514 KiB  
Article
Development and Optimization of In-house ELISA for Detection of Human IgG Antibody to SARS-CoV-2 Full Length Spike Protein
by Thamir A. Alandijany, Sherif A. El-Kafrawy, Ahmed M. Tolah, Sayed S. Sohrab, Arwa A. Faizo, Ahmed M. Hassan, Tagreed L. Alsubhi, Norah A. Othman and Esam I. Azhar
Pathogens 2020, 9(10), 803; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens9100803 - 28 Sep 2020
Cited by 26 | Viewed by 7249
Abstract
The ongoing coronavirus disease 19 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a threat to human health. Despite this, many affected countries are now in the process of gradual lifting of COVID-19 restrictions that were initially [...] Read more.
The ongoing coronavirus disease 19 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a threat to human health. Despite this, many affected countries are now in the process of gradual lifting of COVID-19 restrictions that were initially implemented in response to the pandemic. The success of the so-called “exit strategy” requires continued surveillance of virus circulation in the community and evaluation of the prevalence of protective immunity among population. Serology tests are valuable tools for these purposes. Herein, SARS-CoV-2 full-length spike (S) recombinant protein was utilized to develop and optimize an indirect enzyme-linked immunoassay (ELISA) that enables a reliable detection of virus-specific IgG antibody in human sera. Importantly, the performance of this assay was evaluated utilizing micro-neutralization (MN) assay as a reference test. Our developed ELISA offers 100% sensitivity, 98.4% specificity, 98.8% agreement, and high overall accuracy. Moreover, the optical density (OD) values of positive samples significantly correlated with their MN titers. The assay specifically detects human IgG antibodies directed against SARS-CoV-2, but not those to Middle East respiratory syndrome coronavirus (MERS-CoV) or human coronavirus HKU1 (HCoV-HKU1). The availability of this in-house ELISA protocol would be valuable for various diagnostic and epidemiological applications. Full article
(This article belongs to the Special Issue COVID-19 in Low and Middle Income Countries)
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11 pages, 252 KiB  
Article
COVID-19 in Somalia: Adherence to Preventive Measures and Evolution of the Disease Burden
by Mohammed A. M. Ahmed, Joseph Nelson Siewe Fodjo, Abdi A. Gele, Abdiqani A. Farah, Shariff Osman, Ibraahim Abdullahi Guled, Abdiaziz Mohamed Ali and Robert Colebunders
Pathogens 2020, 9(9), 735; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens9090735 - 06 Sep 2020
Cited by 27 | Viewed by 6752
Abstract
Following the COVID-19 outbreak in Somalia, strict preventive measures were implemented by the government. We assessed adherence to the government recommendations via two consecutive online cross-sectional surveys between April and July 2020. A five-point adherence score was constructed based on self-reported observance of [...] Read more.
Following the COVID-19 outbreak in Somalia, strict preventive measures were implemented by the government. We assessed adherence to the government recommendations via two consecutive online cross-sectional surveys between April and July 2020. A five-point adherence score was constructed based on self-reported observance of five preventive measures (physical distancing, face mask use, hand hygiene, mouth covering when coughing/sneezing, and avoidance of touching the face). 4124 and 4703 responses were analyzed during the first and second survey, respectively. The mean adherence score decreased from 3.54 ± 1.5 in the first survey to 3.40 ± 1.6 during the second survey; p < 0.001. More participants experienced at least one flu-like symptom during the second survey (38.2%) compared to the first (16.2%); however, the proportion of positive COVID-19 tests in the first (26.9%) and second survey (26.5%) was similar. The ordinal logistic regression model identified the following predictors for high adherence scores: female gender (odds ratio (OR) = 1.715 (1.581–1.861), p < 0.001); being a healthcare worker/student (OR = 2.180 (2.000–2.377), p < 0.001); obtaining COVID-19 information from official sources (OR = 1.460 (1.341–1.589), p < 0.001); and having postgraduate education (OR = 1.679 (1.220–2.307), p < 0.001). Conversely, obtaining COVID-19 information from social media and residing in urban settings were associated with lower adherence. Targeted and context-specific adaptations of the COVID-19 response may be required in Somalia. Full article
(This article belongs to the Special Issue COVID-19 in Low and Middle Income Countries)

Other

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19 pages, 6700 KiB  
Systematic Review
COVID-19, Livestock Systems and Food Security in Developing Countries: A Systematic Review of an Emerging Literature
by Assem Abu Hatab, Lena Krautscheid and Sofia Boqvist
Pathogens 2021, 10(5), 586; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens10050586 - 11 May 2021
Cited by 26 | Viewed by 6400
Abstract
In this paper, we carried out a systematic literature review to document the emerging scientific knowledge about COVID-19 impact on livestock systems and food security in developing countries to identify gaps and possible avenues for future research undertakings. Specifically, we systematically reviewed 68 [...] Read more.
In this paper, we carried out a systematic literature review to document the emerging scientific knowledge about COVID-19 impact on livestock systems and food security in developing countries to identify gaps and possible avenues for future research undertakings. Specifically, we systematically reviewed 68 peer-reviewed articles extracted based on rigorous selection criteria from Scopus, PubMed and ISI Web of Science databases and published between December 2019 and February 2021. Our results reveal that livestock supply chains presented an important ‘intermediary’ pathway through which the pandemic affected various dimensions of food security in developing countries. Although the research response has been rapid in terms of both quantity and temporal succession, we find a highly suggestive disjunction in studies analyzing the interconnections between COVID-19 pandemic, livestock systems and food security in developing countries. With respect to the livestock supply chain, the bulk of the reviewed evidence focuses on production and consumption, whereas considerably less focus is given to the pandemic’s impact on intermediaries within livestock chains, including traders, intermediaries and processors. The analysis of livestock supply chain resilience revolves predominantly around the ‘absorbance’ and ‘recovery’ phases of resilience, whereas only a small subset of the literature investigates actions taken by supply chain actors to ‘plan’ or to ‘adapt’ livestock systems in order to reduce their vulnerability and enhance their overall resilience. Furthermore, food security has often been narrowly defined, with the majority of articles focusing on ‘availability’ and ‘accessibility’ to food due to the pandemic, and other dimensions of food security, including utilization, stability and sustainability, have been widely neglected. Based on our findings, we recommend future research to examine the dynamics of propagation of COVID-19 impact through livestock supply chains in order to develop more targeted interventions that enhance the capacity of developing countries to cope with this and future disruptions and mitigate their food insecurity outcomes. To this end, more holistic, integrated and resilience-based approaches are much recommended to recognize the complex nature of livestock systems in developing countries and to address the multifaceted and widespread effects of COVID-19 on food security channeled through livestock chains. Full article
(This article belongs to the Special Issue COVID-19 in Low and Middle Income Countries)
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