Carcinogenic and Anti-carcinogenic Bacteria

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 4378

Special Issue Editor


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Guest Editor
Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, Poland
Interests: microbiology; molecular biology; microbial pathogenesis; bacterial proteins and toxins; antimicrobials
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Special Issue Information

Dear Colleagues,

For many years, the most known bacterial carcinogen was Helicobacter pylori. With the development of science, especially molecular diagnostics, including NGS, it has been noticed that other bacteria may also be involved in cancer. A particular role is currently attributed to oral pathogens (e.g., Streptococcus sp., Prevotella sp., Fusobacterium sp., Porphyromonas gingivalis, and Capnocytophaga gingivalis). These pathogens can have an impact on the development of oral and esophageal cancers. Many works have also shown that mainly Fusobacterium nucleatum and Porphyromonas gingivalis play an important role in the development of colorectal and pancreatic cancer. On the other hand, already in the nineteenth century, Dr. William Coley presented anti-cancer microbes, now called the Coley’s toxin. Anti-carcinogenic activity may also exert probiotic bacteria (e.g., Lactobacillus sp.). For this Special Issue, we invite you to send original or review papers on aspects of bacterial carcinogenesis and the anti-cancer activity of bacteria.

Assoc. Prof. Tomasz Karpiński
Guest Editor

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Keywords

  • carcinogenic bacteria
  • anti-cancer bacteria
  • chronic inflammation
  • antiapoptotic activity
  • cancerogenic substances
  • probiotics
  • pathogenesis
  • virulence factors

Published Papers (1 paper)

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Research

25 pages, 4618 KiB  
Article
Single Donor FMT Reverses Microbial/Immune Dysbiosis and Induces Clinical Remission in a Rat Model of Acute Colitis
by Petra Adamkova, Petra Hradicka, Sona Gancarcikova, Monika Kassayova, Lubos Ambro, Izabela Bertkova, Martin Maronek, Silvia Farkasova Iannaccone and Vlasta Demeckova
Pathogens 2021, 10(2), 152; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens10020152 - 02 Feb 2021
Cited by 2 | Viewed by 2827
Abstract
Deviation in the gut microbial composition is involved in various pathologies, including inflammatory bowel disease (IBD). Faecal microbiota transplant (FMT) can act as a promising approach to treat IBD by which changes in microbiome can be reversed and homeostasis restored. Therefore, the aim [...] Read more.
Deviation in the gut microbial composition is involved in various pathologies, including inflammatory bowel disease (IBD). Faecal microbiota transplant (FMT) can act as a promising approach to treat IBD by which changes in microbiome can be reversed and homeostasis restored. Therefore, the aim of this study was to investigate the effect of FMT on the remission of acute inflammatory response using dextran sulfate sodium (DSS)-induced rat colitis model. Faecal microbial communities were analysed using the 16S rRNA approach, and clinical manifestations together with histological/haematological/biochemical/immunological analyses were assessed. Our study demonstrated significant shifts in the dominant species of microbiota under inflammatory conditions induced by DSS and evident restoration effect of FMT treatment on microbial composition. These faecal microbial alterations in FMT-treated rats led to a relative restoration of colon length, and a significant decrease in both epithelium damage and disease severity, which was reflected in lower serum pro-inflammatory cytokine levels. Haematological/biochemical parameters in DSS-treated animals showed signs of anaemia with a significant reduction in red blood cell count together with increasing levels of total bilirubin, creatinine and phosphorus suggesting potential protective effect of FMT. These results support FMT as a valuable therapeutic strategy to control inflammation during acute colitis. Full article
(This article belongs to the Special Issue Carcinogenic and Anti-carcinogenic Bacteria)
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