Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.1
3.7
Journals
Pathogens
Special Issues
Emerging Vector-Borne Viral Diseases
share announcement

Emerging Vector-Borne Viral Diseases

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 6301

Special Issue Editors

Dr. Nazli Ayhan

E-Mail Website
Guest Editor
Unité des Virus Emergents (Aix Marseille Université, IRD 190, INSERM U1207, IHU Mediterranee Infection), 13005 Marseille, France
Interests: arthropod-borne viruses; vector-borne viruses; virus discovery; virus taxonomy; epidemiology
Dr. Laura Pezzi

E-Mail Website
Assistant Guest Editor
Unité des Virus Emergents (Aix Marseille Université, IRD 190, INSERM U1207, IHU Mediterranee Infection), 13005 Marseille, France
Interests: epidemiology; diagnostic; arboviruses; emerging viruses
Dr. Raphaelle Klitting

E-Mail Website
Assistant Guest Editor
Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA
Interests: emerging viruses; molecular epidemiology; virus evolution; functional adaptation; viral sequencing; reverse genetics

Special Issue Information

Dear Colleagues,

A significant proportion of emerging infectious diseases are caused by vector-borne viruses, also called ‘arboviruses’, posing a growing risk  to human and animal health, with prominent outbreaks reported in humans (e.g., dengue, chikungunya and Zika virus) and animals (e.g., Bluetongue, African swine fever, Usutu, West Nile and Rift Valley fever virus) in recent years.
The distribution of arthropod vectors such as ticks, mosquitos, sand flies and biting midges was effected by environmental modifications, climate change, urbanization and globalization. Changes in vector distribution and arthropod adaptation of vectors to urbanization have a direct impact on increasing emerging vector-borne viruses in local and global scale. These driving forces, coupled with other social, economic and microbiological factors, increasingly favor the emergence and spread of vector-borne viruses worldwide.
This Special Issue seeks to cover the theme of the vector-borne viral emergence, considering all research studies regarding topics relevant to this theme, including the epidemiology of arboviruses, vector–host interactions, diagnostics, arbovirus evolution, transmission pathways of vector-borne viruses, clinical aspects of arbovirus infections and virus discovery.
Quoting Charles Darwin, “doing what little one can to increase the general stock of knowledge is as respectable an object of life, as one can in any likelihood pursue”.

Dr. Nazli Ayhan
Dr. Laura Pezzi
Dr. Raphaelle Klitting
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • arthropod-borne virus
  • arboviruses
  • vector-borne viruses
  • emergent viruses
  • vector-borne viral diseases
  • diagnostic
  • epidemiology

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

15 pages, 2445 KiB  
Article
Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays
by Beatrice E. Tyrrell, Abhinav Kumar, Bevin Gangadharan, Dominic Alonzi, Juliane Brun, Michelle Hill, Tehmina Bharucha, Andrew Bosworth, Victoria Graham, Stuart Dowall, Joanna L. Miller and Nicole Zitzmann
Pathogens 2023, 12(3), 399; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens12030399 - 01 Mar 2023
Viewed by 1879
Abstract
Crimean-Congo haemorrhagic fever virus (CCHFV) is a pathogen of increasing public health concern, being a widely distributed arbovirus and the causative agent of the potentially fatal Crimean-Congo haemorrhagic fever. Hazara virus (HAZV) is a genetically and serologically related virus that has been proposed [...] Read more.
Crimean-Congo haemorrhagic fever virus (CCHFV) is a pathogen of increasing public health concern, being a widely distributed arbovirus and the causative agent of the potentially fatal Crimean-Congo haemorrhagic fever. Hazara virus (HAZV) is a genetically and serologically related virus that has been proposed as a surrogate for antiviral and vaccine testing for CCHFV. Glycosylation analysis of HAZV has been limited; first, we confirmed for the first time the occupation of two N-glycosylation sites in the HAZV glycoprotein. Despite this, there was no apparent antiviral efficacy of a panel of iminosugars against HAZV, as determined by quantification of the total secretion and infectious virus titres produced following infection of SW13 and Vero cells. This lack of efficacy was not due to an inability of deoxynojirimycin (DNJ)-derivative iminosugars to access and inhibit endoplasmic reticulum α-glucosidases, as demonstrated by free oligosaccharide analysis in uninfected and infected SW13 and uninfected Vero cells. Even so, iminosugars may yet have potential as antivirals for CCHFV since the positions and importance of N-linked glycans may differ between the viruses, a hypothesis requiring further evaluation. Full article
(This article belongs to the Special Issue Emerging Vector-Borne Viral Diseases)
►▼ Show Figures

Figure 1

8 pages, 958 KiB  
Article
Determinants of Health-Related Quality of Life in Chronic Chikungunya Disease in Guadeloupe
by Fabrice Simon, Rémi Bossy, Denise Federico, Julien Dezaunay, Anne-Laurence Demoux, Nadia Rugard, Giulia Calusi, Andrea Nizzardo, Hugh Watson and Franciane Gane-Troplent
Pathogens 2022, 11(9), 989; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens11090989 - 30 Aug 2022
Cited by 1 | Viewed by 1555
Abstract
Chronic chikungunya disease is associated with a poor quality of life and a variety of symptoms, not restricted to the musculoskeletal system. Patients with chronic chikungunya disease in Guadeloupe were evaluated in order to identify the main factors determining the quality of life. [...] Read more.
Chronic chikungunya disease is associated with a poor quality of life and a variety of symptoms, not restricted to the musculoskeletal system. Patients with chronic chikungunya disease in Guadeloupe were evaluated in order to identify the main factors determining the quality of life. Patients were followed up at a mean of 36 months after chikungunya infection, undergoing detailed clinical examination for musculoskeletal involvement, with assessment of subjective symptoms and the impact on mood, physical activity, and quality of life (SF12). Patients had extensive musculoskeletal involvement shown by tenderness in 9 ± 4 joints and stiffness in 5 ± 4 joints. SF12 physical and mental component scores showed a poor health-related quality of life. Measures of joint pain, stiffness, and inflammation contributed to impaired quality of life scores. In addition, fatigue and interrupted sleep appeared to be important predictors for physical aspects of quality of life. The emergence of anxiodepressive syndromes post-chikungunya infection was associated with both physical and mental component scores of SF12. These data confirm that musculoskeletal symptoms are not the only determinants of quality of life in chronic chikungunya disease. Follow-up of patients should include assessment and management of fatigue, poor sleep quality, and anxiodepressive syndromes. Full article
(This article belongs to the Special Issue Emerging Vector-Borne Viral Diseases)
►▼ Show Figures

Figure 1

11 pages, 2702 KiB  
Article
Human Polymorphonuclear Cells Support Zika Virus to Cross Endothelial Monolayer and Access Bloodstream
by Claudia Gandolfo, Chiara Terrosi, Shibily Prathyumnan, Gabriele Anichini, Gianni Gori Savellini, Giuseppe Morgante and Maria Grazia Cusi
Pathogens 2022, 11(3), 321; https://0-doi-org.brum.beds.ac.uk/10.3390/pathogens11030321 - 05 Mar 2022
Viewed by 1865
Abstract
The rapid spread of new outbreaks of human infection caused by Zika virus (ZIKV) has raised many global concerns since 2016. Despite the increasing knowledge of this virus, data on the pathogenesis of ZIKV are still missing. In particular, it is still unknown [...] Read more.
The rapid spread of new outbreaks of human infection caused by Zika virus (ZIKV) has raised many global concerns since 2016. Despite the increasing knowledge of this virus, data on the pathogenesis of ZIKV are still missing. In particular, it is still unknown how the virus crosses the endothelial monolayer and gets access to the bloodstream. In the present work, we used human umbilical vein endothelial cells (HUVECs) as a model to study ZIKV infection in vitro. We demonstrated that HUVECs are an optimal reservoir for viral replication, as they were able to sustain ZIKV infection up to two weeks, without showing a cytopathic effect. In order to evaluate the integrity of endothelial monolayer, immunofluorescence was performed on mock-infected or ZIKV-infected cells ± peripheral blood mononuclear cells (PBMCs) or polymorphonuclear cells (PMN), 48 h p.i., by using an anti-VE-Cadherin antibody, a major adherence protein that maintains the integrity of intercellular junctions. In addition to infection, we noted that the presence of some components of the immune system, such as PMNs, played an important role in altering the endothelial monolayer in cell junctions, suggesting that presence at the site of infection probably promotes the spread of ZIKV in vivo in the bloodstream. Full article
(This article belongs to the Special Issue Emerging Vector-Borne Viral Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop