Special Issue "Promising Anti-inflammatory Medicinal Plants—An Assessment of Bioavailability, Pharmacokinetics, Clinical Efficacy and Overview of New Methodological Approaches"
Deadline for manuscript submissions: closed (30 June 2021).
Interests: medicinal plants; inflammation; bioavailability; personalized medicine; pharmaceutical analysis, pharmaceutical quality.
Even though monoclonal antibodies and next-gen therapeutics form a major part of new pharmaceutical developments, the great interest in medicinal plants remains unbroken. This is for good reason, because the complex herbal composition allows for multicomponent and multi-target synergistic effects that can rarely be achieved by a single synthetic or biological drug.
Nevertheless, many promising pharmacological effects revealed for medicinal plants and extracts in in vitro assays fail in vivo. This is due to several factors, ranging from not knowing the pharmacologically active ingredients in a complex composition to not achieving in vivo the high concentrations applied in vitro because of poor absorption following oral administration. The only way to break this vicious circle is to close the gap between the data obtained from pharmacological assays and clinical reality by a good pharmacokinetic understanding of the active components and their final concentrations in the body at the site of action.
This Special Issue aims to summarize the state-of-the-art and the latest findings as well as to elucidate future developments in analytical methods and predictive models that can help us to bridge the gap between proven pharmacological in vitro actions and possible resulting clinical effects. In contrast to previous Special Issues dealing generally with medicinal plants (https://0-www-mdpi-com.brum.beds.ac.uk/journal/pharmaceuticals/special_issues/med_plants_2020) and bioactive compounds from plants and foods of pharmaceutical interest (https://0-www-mdpi-com.brum.beds.ac.uk/journal/pharmaceuticals/special_issues/bio_pharmaceutical), this Special Issue focuses on recent pharmacokinetic- and bioavailability-related insights gained into medicinal plants with anti-inflammatory effects while also taking into consideration future analytical and predictive developments.
Interested experts in this field are invited to promote the research on and clinical use of promising anti-inflammatory medicinal plants by submitting a research manuscript, short communication, or review article addressing:
- the pharmacokinetics and bioavailability of potential anti-inflammatory herbal agents;
- promising clinical trials supporting the use of medicinal plants in clinical practice for treating inflammatory diseases;
- clinically relevant pharmacokinetic drug interactions with medicinal plants;
- new insights into clinically relevant mechanistic actions of promising anti-inflammatory herbal ingredients;
- approaches to enhancing the bioavailability of poorly soluble herbal ingredients;
- physiologically relevant predictive in vitro systems for better simulation of the absorption process;
- untargeted metabolomic profiling for the identification of the absorbed components from medicinal plants; or
- future analytical tools and models to better characterize active herbal ingredients in vitro and in vivo.
By your contribution, you pave the way to greater evidence-based use of anti-inflammatory medicinal plants in clinical practice. I look forward to your participation in this mission.
Prof. Dr. Mona Abdel-Tawab
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- medicinal plants
- clinical trials
- metabolomics profiling
- predictive absorption models