Special Issue "New Advances in the Treatment of Nonalcoholic Fatty Liver Disease"
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: closed (30 June 2018).
Nonalcoholic fatty liver disease (NAFLD), is the most common liver disease worldwide. The estimated prevalence of NAFLD in the Western world, and in the urban areas of developing countries, is around 25% in the general population.
NAFLD is now considered the hepatic border of metabolic syndrome, supported by a high-calorie dietetic regimen, in the presence of a genetic profile characterized by predisposing polymorphisms. The “multi parallel hit” pathogenetic hypothesis of NAFLD, suggest that fat accumulation in the hepatocytes exposes the liver to oxidative stress with reactive oxygen species production, inflammation unbalance, cellular necrosis and, finally, fibrosis.
Several pharmacological treatments have been proposed in the last two decades for the treatment of NAFLD, but the reported results are inconclusive. In this way, international guidelines are been published on the management of patients with NAFLD and its related research agenda. However, many questions remain open. This Special Issue aims to become an overview about the currently available knowledge and recent findings regarding NAFLD therapies. I am honored to invite my distinguished colleagues to contribute with reviews and research articles that will stimulate the continuing efforts to better define the therapeutic management of NAFLD in clinical practice and to define the next five years of perspectives.Prof. Dr. Ludovico Abenavoli
Manuscript Submission Information
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- nonalcoholic fatty liver disease
- new treatment
- insulin resistance
- liver fibrosis