Special Issue "Cerebral Production and Action of Pro-inflammatory Cytokines"
Deadline for manuscript submissions: 30 July 2021.
Interests: blood-brain interface, cytokine, food intake, inflammation, sickness behavior
Special Issues and Collections in MDPI journals
The aim of this Special Issue is to better understand cytokine production and action in the brain beyond their involvement in local immune responses to an insult or infection of the central nervous system (CNS). One domain in which research into brain cytokine production and action has been particularly active over the past few decades is that aiming to explain the occurrence of nonspecific disease symptoms involving CNS-regulated physiology and behavior, such as fever, increased sleep, and reduced food intake, after the systemic detection of bacterial fragments. Another domain of research addressing the role of brain cytokine production and action concerns the regulation of some important biological functions like sleep and energy balance.
While the majority of the work on brain cytokine production and action has historically been on pro-inflammatory cytokines such as interleukin-1, it is important to realize that cytokines comprise many different biologically-active molecules and include interferons, interleukins, and chemokines, but also adipokines, such as leptin. Thus, several new perspectives have arisen on cytokine brain production and action that surpass the domain of classic neuroimmunology and seem closer in spirit to integrative physiology and behavior. These new perspectives can be expected to give rise to new potential therapeutic avenues of pharmacological intervention strategies.
This Special Issue may include manuscripts on the role of brain cytokine production and action in relation to brain networks (neuronal and non-neuronal) involved in physiology, behavior, emotion, and cognition in health and disease beyond their action in mediating cellular responses to local injury or infection of the CNS. We thus welcome papers reporting new experimental research or methods, clinical studies and trials, and reviews with original theoretical perspectives from international researchers and clinicians.
Dr. Jan-Pieter Konsman
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- CNS expression
- energy balance
- health and disease