Special Issue "Multicomponent and Domino Reactions in Drug Discovery"

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 1 July 2022.

Special Issue Editors

Prof. Dr. Francisco Palacios
E-Mail Website
Guest Editor
Departamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados “Lucio Lascaray”- Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain
Interests: organic synthesis; organophosphorus chemistry; fluorine chemistry; heterocyclic chemistry; cycloaddition reactions; solid-phase synthesis; design and development of enzyme inhibitors; drug discovery (cancer and neglected tropical diseases)
Dr. Jesús Manuel de Los Santos
E-Mail Website
Guest Editor
Campus Álava, Universidad del Pais Vasco - Euskal Herriko Unibertsitatea, San Sebastián, Spain
Interests: development of new synthetic methodologies, which includes the chemistry of nitrogen- and phosphorus-containing compounds for the preparation of acyclic and cyclic compounds; the discovery of new organocatalytic processes for the synthesis of small chiral organic molecules
Dr. Concepción Alonso
E-Mail Website
Guest Editor
Universidad del Pais Vasco - Euskal Herriko Unibertsitatea, Campus Álava, Vitoria-Gasteiz, Spain
Interests: design, synthesis and development of new methodologies in organic synthesis of heterocyclic compounds; the medicinal chemistry of anticancer, antileishmanial drugs
Dr. Javier Vicario
E-Mail Website
Guest Editor
Campus Álava, Universidad del Pais Vasco - Euskal Herriko Unibertsitatea, Vitoria-Gasteiz, Spain
Interests: preparation of new enantiopure amino acid and aminophosphonic acid derivatives using organocatalytic processes; the development of new multicomponent reactions

Special Issue Information

Dear Colleagues,

The generation of new chemical entities that can serve as potential drug candidates is a key step in the drug discovery process. Successful drug development requires efficient, short and low-cost synthetic methodologies for lead discovery. In this regard, multicomponent reactions (MCRs) and domino reactions have emerged as a powerful new strategy in synthetic organic chemistry and drug discovery, providing a more efficient (fewer steps) and quicker way (less time) to prepare molecular diversity and complexity than methods used in traditional chemistry.

MCRs are defined as one-pot processes in which three or more components react in one synthetic operation to form a single product in a selective way. According to Tietze's definition, a domino reaction is understood as “a process involving two or more consecutive reactions in which subsequent reactions result as a consequence of the functionality formed by bond formation or fragmentation in the previous step”. These reactions are atom-economic, step-efficient, convergent, and they have high exploratory power with regard to chemical space. They are therefore useful alternatives to sequential multistep synthesis, and ideally suited for the generation of compound libraries.

Due to their versatility, MCRs and domino reactions have found applications in many fields of organic chemistry and in medicinal chemistry in particular. The synthetic community in industry and academia has recognized the easy and quick access to biologically relevant compounds by MCRs and domino reactions as preferred methods in the drug discovery process.

The Special Issue “Multicomponent and Domino Reactions in Drug Discovery” will acknowledge research papers with topics including, but not limited to, recent applications in the design, synthesis and in vitro evaluation of new complex molecules with often biologically relevant scaffold structures developed by multicomponent (MCRs) and domino reactions. Review articles and future perspectives shedding light on developments in the field are also welcome.

Prof. Dr. Francisco Palacios
Dr. Jesús Manuel de Los Santos
Dr. Concepción Alonso
Dr. Javier Vicario
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug discovery
  • medicinal chemistry
  • drug synthesis
  • multicomponent reactions
  • domino reactions, bioactivity
  • SAR studies
  • hybrid drugs

Published Papers

This special issue is now open for submission.
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