Chemically Modified Antisense Oligonucleotides: Promising Tools for the Therapy of Diseases
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: closed (28 February 2017)
Special Issue Editors
Interests: RNA biology; regulatory RNA molecules; extracellular vesicles; identification of genetic defects in inherited diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antisense oligonucleotides (AONs) have been widely studied as regulators of gene expression by their direct interaction mainly with RNA or RNA regulating molecules. During the last 20 years, AONs have shown to have the potential to treat various diseases, such as cardiovascular diseases, diabetes, cancer, neurological diseases, and muscular dystrophies. Nevertheless, several drawbacks have been identified towards this way. Introduction of chemical modifications to AONs have shown to be beneficial in several cases, providing among other things, resistance to nucleases, stability, and increased target affinity.
I would like to welcome you to submit articles and reviews on chemically modified AONs against diseases.
Prof. Dr. Leonidas A. Phylactou
Dr. Nikolas Mastroyiannopoulos
Guest Editors
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Keywords
- chemical modification
- antisense oligonucleotide
- nuclease resistance
- binding target mRNA
- systemic delivery
- tissue delivery
