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Pharmaceutics
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Application of Drug Penetration or Delivery in the Fight against...
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Application of Drug Penetration or Delivery in the Fight against Infectious Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 9918

Special Issue Editor

Prof. Dr. Fernando Rogério Pavan

E-Mail Website
Guest Editor
School of Pharmacy, São Paulo State University (UNESP), Araraquara-Jaú Road, Araraquara 148000-903, SP, Brazil
Interests: mycobacterium tuberculosis; new drugs; biological assays; antibiotics; antibiotics resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Infectious diseases have never been more popular than they are today. Concern, especially regarding bacterial resistance, has alerted the world. In recent years, more precisely in 2017, WHO developed a list of 12 main pathogens and more mycobacterium tuberculosis as an urgency in the development of new antibiotics. Nanotechnology is an efficient and very current tool, with several applications including infectious diseases. In this topic, we will address the application of drug penetration or delivery in the fight against infectious diseases. We will accept reviews, research papers and communications. Research papers should be as comprehensive as possible—communications are also acceptable, while letters and short research papers are not.

Prof. Dr. Fernando Rogério Pavan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infectious diseases
  • drug penetration
  • drug delivery
  • new drugs
  • nanotechnology

Published Papers (2 papers)

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Review

24 pages, 1446 KiB  
Review
Application of Lipid-Based Nanocarriers for Antitubercular Drug Delivery: A Review
by Aristote B. Buya, Bwalya A. Witika, Alain M. Bapolisi, Chiluba Mwila, Grady K. Mukubwa, Patrick B. Memvanga, Pedzisai A. Makoni and Christian I. Nkanga
Pharmaceutics 2021, 13(12), 2041; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics13122041 - 30 Nov 2021
Cited by 16 | Viewed by 3432
Abstract
The antimicrobial drugs currently used for the management of tuberculosis (TB) exhibit poor bioavailability that necessitates prolonged treatment regimens and high dosing frequency to achieve optimal therapeutic outcomes. In addition, these agents cause severe adverse effects, as well as having detrimental interactions with [...] Read more.
The antimicrobial drugs currently used for the management of tuberculosis (TB) exhibit poor bioavailability that necessitates prolonged treatment regimens and high dosing frequency to achieve optimal therapeutic outcomes. In addition, these agents cause severe adverse effects, as well as having detrimental interactions with other drugs used in the treatment of comorbid conditions such as HIV/AIDS. The challenges associated with the current TB regimens contribute to low levels of patient adherence and, consequently, the development of multidrug-resistant TB strains. This has led to the urgent need to develop newer drug delivery systems to improve the treatment of TB. Targeted drug delivery systems provide higher drug concentrations at the infection site, thus leading to reduced incidences of adverse effects. Lipid-based nanocarriers have proven to be effective in improving the solubility and bioavailability of antimicrobials whilst decreasing the incidence of adverse effects through targeted delivery. The potential application of lipid-based carriers such as liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, nano and microemulsions, and self-emulsifying drug delivery systems for the treatment of TB is reviewed herein. The composition of the investigated lipid-based carriers, their characteristics, and their influence on bioavailability, toxicity, and sustained drug delivery are also discussed. Overall, lipid-based systems have shown great promise in anti-TB drug delivery applications. The summary of the reviewed data encourages future efforts to boost the translational development of lipid-based nanocarriers to improve TB therapy. Full article
(This article belongs to the Special Issue Application of Drug Penetration or Delivery in the Fight against Infectious Diseases)
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27 pages, 1113 KiB  
Review
Challenge in the Discovery of New Drugs: Antimicrobial Peptides against WHO-List of Critical and High-Priority Bacteria
by Cesar Augusto Roque-Borda, Patricia Bento da Silva, Mosar Corrêa Rodrigues, Ricardo Bentes Azevedo, Leonardo Di Filippo, Jonatas L. Duarte, Marlus Chorilli, Eduardo Festozo Vicente and Fernando Rogério Pavan
Pharmaceutics 2021, 13(6), 773; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics13060773 - 21 May 2021
Cited by 25 | Viewed by 5521
Abstract
Bacterial resistance has intensified in recent years due to the uncontrolled use of conventional drugs, and new bacterial strains with multiple resistance have been reported. This problem may be solved by using antimicrobial peptides (AMPs), which fulfill their bactericidal activity without developing much [...] Read more.
Bacterial resistance has intensified in recent years due to the uncontrolled use of conventional drugs, and new bacterial strains with multiple resistance have been reported. This problem may be solved by using antimicrobial peptides (AMPs), which fulfill their bactericidal activity without developing much bacterial resistance. The rapid interaction between AMPs and the bacterial cell membrane means that the bacteria cannot easily develop resistance mechanisms. In addition, various drugs for clinical use have lost their effect as a conventional treatment; however, the synergistic effect of AMPs with these drugs would help to reactivate and enhance antimicrobial activity. Their efficiency against multi-resistant and extensively resistant bacteria has positioned them as promising molecules to replace or improve conventional drugs. In this review, we examined the importance of antimicrobial peptides and their successful activity against critical and high-priority bacteria published in the WHO list. Full article
(This article belongs to the Special Issue Application of Drug Penetration or Delivery in the Fight against Infectious Diseases)
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