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6.9
5.4
Journals
Pharmaceutics
Special Issues
Advances in Electric and Magnetic Fields Induced Drug Delivery
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Advances in Electric and Magnetic Fields Induced Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 1948

Special Issue Editors

Dr. Sharabi Shirley

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Guest Editor
The Advanced Technology Center, Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel
Interests: pulsed electric fields; electroporation; blood brain barrier; drug delivery; MRI; brain tumors
Dr. Cooper Itzik

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Guest Editor
The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat-Gan 52621, Israel
Interests: blood–brain barrier; neurodegenerative diseases; Alzheimer’s disease; drug delivery

Special Issue Information

Dear Colleagues,

In recent years, the use of external electric and magnetic fields to enhance drug delivery has grown dramatically. Electric fields are being used to cross physical barriers such as vessels or cell membranes either by permeabilization (for example electroporation), electroendocytosis, iontophoresis, or by affecting the para-cellular pathway. Additionally, drug delivery systems such as electroresponsive systems facilitate the delivery of charged or magnetic nanoparticles and conductive polymer-based systems (hydrogel film or nanoparticles). Those systems enable a controlled and localized release of drugs to the desired tissue, limiting systemic side effects. Magnetic fields are being used in combination with magnetic nanoparticles to trigger drug release or to increase drug accumulation in a specific target.

The aim of this Special Issue is to highlight electric and magnetic field-based drug delivery mechanisms.

Authors are invited to submit their original research or review articles within this subject area. Preclinical (in vitro and in vivo) and clinical research as well as theoretical and technical papers are invited.

Dr. Sharabi Shirley
Dr. Itzik Cooper
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Electric and magnetic fields
  • Electroporation
  • Iontophoresis
  • Electro-responsive systems
  • Nanoparticles
  • Electroendocytosis

Published Papers (1 paper)

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Research

20 pages, 5690 KiB  
Article
Moderate Heat-Assisted Gene Electrotransfer as a Potential Delivery Approach for Protein Replacement Therapy through the Skin
by Chelsea Edelblute, Cathryn Mangiamele and Richard Heller
Pharmaceutics 2021, 13(11), 1908; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics13111908 - 11 Nov 2021
Cited by 3 | Viewed by 1572
Abstract
Gene-based approaches for protein replacement therapies have the potential to reduce the number of administrations. Our previous work demonstrated that expression could be enhanced and/or the applied voltage reduced by preheating the tissue prior to pulse administration. In the current study, we utilized [...] Read more.
Gene-based approaches for protein replacement therapies have the potential to reduce the number of administrations. Our previous work demonstrated that expression could be enhanced and/or the applied voltage reduced by preheating the tissue prior to pulse administration. In the current study, we utilized our 16-pin multi-electrode array (MEA) and incorporated nine optical fibers, connected to an infrared laser, between each set of four electrodes to heat the tissue to 43 °C. For proof of principle, a guinea pig model was used to test delivery of reporter genes. We observed that when the skin was preheated, it was possible to achieve the same expression levels as gene electrotransfer without preheating, but with a 23% reduction of applied voltage or a 50% reduction of pulse number. With respect to expression distribution, preheating allowed for delivery to the deep dermis and muscle. This suggested that this cutaneous delivery approach has the potential to achieve expression in the systemic circulation, thus this protocol was repeated using a plasmid encoding Human Factor IX. Elevated Factor IX serum protein levels were detected by ELISA up to 100 days post gene delivery. Further work will involve optimizing protein levels and scalability in an effort to reduce application frequency. Full article
(This article belongs to the Special Issue Advances in Electric and Magnetic Fields Induced Drug Delivery)
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