Special Issue "Alternative Methods to Animal Testing on the Assessment of Drug Permeation Across Different Barriers, Focusing on the Skin and Eye"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Dr. Susi Burgalassi
E-Mail Website
Guest Editor
Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
Interests: pharmaceutical formulation development and evaluation, ocular drug delivery, mucosal drug delivery, mucoadhesive formulations
Special Issues and Collections in MDPI journals
Ms. Erica Zucchetti
Assistant Guest Editor
Department of Pharmacy, University of Pisa, 56126 Pisa, Italy
Interests: pharmaceutical formulation; ocular drug delivery

Special Issue Information

Dear Colleagues,

The number of animals used in research has significantly increased with the advancement of sciences and the development of medical technology. This has led to an increasing demand and implementation of alternatives approaches that can partially or entirely replace laboratory animals, also in line with the guiding principles of the 3Rs (Replacement, Reduction, and Refinement).

Mainly, there are two alternatives to in vivo animal testing: the use of cell culture to develop 2D assays or more complex 3D structures and the application of in silico computer simulations.

The development of new drugs or delivery systems involves a plethora of tests on animals, including assays to evaluate the ability of molecules to permeate membranes and tissues of our body.

This Special Issue will focus on in vitro and in silico alternative methods to the use of animals for drug permeation studies across the ocular and cutaneous barriers.

Prof. Dr. Susi Burgalassi
Ms. Erica Zucchetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • alternative methods
  • permeation
  • cell cultures
  • computer simulation
  • cornea model
  • ocular barrier
  • cutaneous barrier
  • skin model

Published Papers

This special issue is now open for submission.
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