Site Specific Delivery of Biomolecules Using Conjugated Macromolecules and Nanocarriers
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 2945
Special Issue Editors
Interests: liver; hepatocytes; toxicity evaluation; polymeric nanoparticles; drug delivery
Interests: anionic ring-opening polymerization of β-substituted β-lactones in presence of functional initiators; chemical modifications; functionalized (co)polyesters carrying molecules of interest (targeting agents, drugs, therapeutic genes, fluorescence probes, radionuclides, etc.); characterizations of (co)polymers; self-assembly of amphiphilic copolymers and hydrophobic homopolymers; development of multifunctional nanoparticles for therapeutic purposes; site-specific drug delivery systems; therapy and/or diagnosis of hepatocellular carcinoma
Special Issues, Collections and Topics in MDPI journals
Interests: nuclear medicine; vectorization; nanoparticles; cancer treatment; multimodal imaging; bioinorganic chemistry
Special Issue Information
Dear Colleagues,
The field of drug delivery systems has grown exponentially in the past decade with the production of many bioconjugated macromolecules and nanocarriers for clinical applications in oncology, gene therapy, immunology, as well as inflammatory and infectious diseases. The rationale for the use of drug delivery systems relies on the fact that most “native” drugs administered by systemic injection distribute evenly throughout the body, resulting in low plasma drug concentration, limited bioavailability, rapid metabolism, and side-effects in healthy organs. Drug delivery systems appear as suitable tools to achieve prolonged plasma concentrations of therapeutic payloads and higher site-specific delivery.
This Special Issue seeks to describe advanced drug delivery systems such as peptide- and polymer-bioconjugates, monoclonal antibodies, affitins or supramolecular aggregates, and lipid/polymer nanocarriers designed to improve their drug loading (radiopharmaceutics, xenobiotics, peptides, or nucleic acids), stealth properties, biocompatibility, and organ/cell targeting through the development of specific chemical synthesis and functionalization. This Special Issue will consider contributions on the synthesis and physicochemical characterization of drug delivery systems, as well as their in vitro cell uptake and biocompatibility, their mode(s) of administration, and their biotechnological, pharmaceutical, and diagnostic applications.
Dr. Pascal Loyer
Dr. Sandrine Cammas-Marion
Dr. Nicolas Lepareur
Dr. Mickaël Bourgeois
Guest Editors
Manuscript Submission Information
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Keywords
- drug delivery systems
- bioconjugates
- nanocarriers
- cell targeting
- vectorization of bioactive molecules
- theranostics
