Nanomedicines for Advanced Treatment and Diagnosis of Inflammation

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (20 July 2021) | Viewed by 2892

Special Issue Editor


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Guest Editor
Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovský Sq. 2, 162 06 Prague 6, Czech Republic
Interests: inflammation; drug delivery; drug targeting; stimuli-sensitive behavior; resolution; theranostics; micelles; polymer carriers; overcoming of biological barriers
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Special Issue Information

Dear Colleagues,

Inflammation is a vital defense mechanism of the immune system for removing harmful stimuli and initiating the healing process. However, dysregulation of immune response and inflammation persistence due to inadequate resolution may lead to chronic inflammation with severe clinical symptoms having substantial socio-economic impact, high prevalence, and severe limitation of patient quality of life. Indeed, nanomedicines have attracted attention as suitable materials for diverse advanced medical applications for the last few decades. Among the studied nanomaterials, polymers, micelles, liposomes, and nanoparticles applicable for inflammation treatment belong to highly promising drug delivery systems, which allow for the controlled delivery and/or targeting of drugs, biomolecules, imaging, and contrast agents to the inflammation site.

This Special Issue of Pharmaceutics focuses on new strategies and approaches to nanomedicine-based systems intended for advanced anti-inflammatory therapy, which could help to solve issues dealing with passive and active targeting, resolution of inflammation, occurrence of side effects, and overcoming of biological barriers. We welcome articles concerning all aspects of nanomedicines intended for advanced therapy or diagnosis of inflammation. In particular, submissions on new materials, strategies, and synthetic approaches are welcome for this Special Issue.

Prof. Tomáš Etrych
Guest Editor

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Keywords

  • Inflammation
  • Drug delivery
  • Drug targeting
  • Stimuli-sensitive behavior
  • Resolution
  • Theranostics
  • Micelles
  • Polymer carriers
  • Overcoming of biological barriers

Published Papers (1 paper)

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19 pages, 2710 KiB  
Article
Polymer Nanomedicines with Ph-Sensitive Release of Dexamethasone for the Localized Treatment of Inflammation
by Alena Libánská, Eva Randárová, Franck Lager, Gilles Renault, Daniel Scherman and Tomáš Etrych
Pharmaceutics 2020, 12(8), 700; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics12080700 - 25 Jul 2020
Cited by 9 | Viewed by 2530
Abstract
Polymer-drug conjugates have several advantages in controlled drug delivery to inflammation as they can accumulate and release the drug in inflamed tissues or cells, which could circumvent the shortcomings of current therapy. To improve the therapeutic potential of polymer-drug conjugates in joint inflammation, [...] Read more.
Polymer-drug conjugates have several advantages in controlled drug delivery to inflammation as they can accumulate and release the drug in inflamed tissues or cells, which could circumvent the shortcomings of current therapy. To improve the therapeutic potential of polymer-drug conjugates in joint inflammation, we synthesized polymer conjugates based on N-(2-hydroxypropyl) methacrylamide) copolymers labeled with a near-infrared fluorescent dye and covalently linked to the anti-inflammatory drug dexamethasone (DEX). The drug was bound to the polymer via a spacer enabling pH-sensitive drug release in conditions mimicking the environment inside inflammation-related cells. An in vivo murine model of adjuvant-induced arthritis was used to confirm the accumulation of polymer conjugates in arthritic joints, which occurred rapidly after conjugate application and remained until the end of the experiment. Several tested dosage schemes of polymer DEX-OPB conjugate showed superior anti-inflammatory efficacy. The highest therapeutic effect was obtained by repeated i.p. application of polymer conjugate (3 × 1 mg/kg of DEX eq.), which led to a reduction in the severity of inflammation in the ankle by more than 90%, compared to 40% in mice treated with free DEX. Full article
(This article belongs to the Special Issue Nanomedicines for Advanced Treatment and Diagnosis of Inflammation)
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