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Pharmaceutics
Special Issues
Biological Evaluation and Biomedical Application of Nanoparticles-Based Formulations
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Biological Evaluation and Biomedical Application of Nanoparticles-Based Formulations

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: closed (10 July 2022) | Viewed by 3263

Special Issue Editors

Dr. Khair Alhareth

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Guest Editor
Chemical and Biological Technologies for Health Group (UTCBS), CNRS, INSERM, Université de Paris, F-75006 Paris, France
Interests: nanomedicine; drug delivery; hybrid nanoparticles; liposomes; placental barrier; nasal administration; microfluidics-based nanoparticles production
Prof. Dr. Karine Andrieux

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Guest Editor
Chemical and Biological Technologies for Health Group (UTCBS), CNRS, INSERM, Université de Paris, F-75006 Paris, France
Interests: nanomedicine; drug delivery; blood brain barriers, placenta models, liposomes and lipoplexes, neurodegenerative diseases; pregnancy disorders

Special Issue Information

Dear Colleagues,

Nanoparticles-based pharmaceutical dosage forms became one of the major research areas in pharmaceutical research. The choice of lipid nanoparticles as a carrier for siRNA and mRNA in a recent marketed drug and vaccines highlights the advancements in production, characterization, and biological evaluation of nanoparticles for therapeutic and diagnostic applications.

Uptake, toxicity, passage through a biological barrier, and biodistribution of nanoparticles are usually evaluated using customized protocols and experimental models. Advanced analytical tools could be also associated with the biological models to get more specific information.

This Special Issue will therefore consider some of the recent studies in the field of biological evaluation and applications of nanomedicines. It is open for studies that describe and discuss an original approach, technical advancement, or new models regarding nanoparticles' evaluation and models validation. Reviews discussing this topic are also welcomed.

Dr. Khair Alhareth
Prof. Dr. Karine Andrieux
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biological models
  • liposomes
  • nanoparticles
  • drug delivery
  • siRNA and mRNA delivery
  • advanced technologies
  • in vitro/in vivo correlation

Published Papers (1 paper)

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Research

13 pages, 3859 KiB  
Article
Gold Nanoparticles Affect Pericyte Biology and Capillary Tube Formation
by Sasikarn Looprasertkul, Amornpun Sereemaspun, Nakarin Kitkumthorn, Kanidta Sooklert, Tewarit Sarachana and Depicha Jindatip
Pharmaceutics 2021, 13(5), 738; https://0-doi-org.brum.beds.ac.uk/10.3390/pharmaceutics13050738 - 17 May 2021
Cited by 5 | Viewed by 2528
Abstract
Gold nanoparticles (AuNPs) are used for diagnostic and therapeutic purposes, especially antiangiogenesis, which are accomplished via inhibition of endothelial cell proliferation, migration, and tube formation. However, no research has been performed on the effects of AuNPs in pericytes, which play vital roles in [...] Read more.
Gold nanoparticles (AuNPs) are used for diagnostic and therapeutic purposes, especially antiangiogenesis, which are accomplished via inhibition of endothelial cell proliferation, migration, and tube formation. However, no research has been performed on the effects of AuNPs in pericytes, which play vital roles in endothelial cell functions and capillary tube formation during physiological and pathological processes. Therefore, the effects of AuNPs on the morphology and functions of pericytes need to be elucidated. This study treated human placental pericytes in monoculture with 20 nm AuNPs at a concentration of 30 ppm. Ki-67 and platelet-derived growth factor receptor-β (PDGFR-β) mRNA expression was measured using real-time reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Cell migration was assessed by Transwell migration assay. The fine structures of pericytes were observed by transmission electron microscopy. In addition, 30 ppm AuNP-treated pericytes and intact human umbilical vein endothelial cells were cocultured on Matrigel to form three-dimensional (3D) capillary tubes. The results demonstrated that AuNPs significantly inhibited proliferation, reduced PDGFR-β mRNA expression, and decreased migration in pericytes. Ultrastructural analysis of pericytes revealed AuNPs in late endosomes, autolysosomes, and mitochondria. Remarkably, many mitochondria were swollen or damaged. Additionally, capillary tube formation was reduced. We found that numerous pericytes on 3D capillary tubes were round and did not extend their processes along the tubes, which resulted in more incomplete tube formation in the treatment group compared with the control group. In summary, AuNPs can affect pericyte proliferation, PDGFR-β mRNA expression, migration, morphology, and capillary tube formation. The findings highlight the possible application of AuNPs in pericyte-targeted therapy for antiangiogenesis. Full article
(This article belongs to the Special Issue Biological Evaluation and Biomedical Application of Nanoparticles-Based Formulations)
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