Special Issue "Nanosuspensions for the Improvement of Drug Bioavailability"
Deadline for manuscript submissions: 28 February 2022.
Interests: nanocrystals; lipid nanoparticles; dermal delivery
Interests: nucleic acid delivery; lipid nanoparticles; nanocrystals for topical application
Interests: liposomes; nanocrystals; lipid nanoparticles; dermal delivery
Solubility is a critical property of any drug, which need to be dissolved in biological fluids to be absorbed and interact with their molecular target(s). The majority of new chemical entities in discovery and development, and a number of approved compounds listed in classes II and IV of the Biopharmaceutical Classification System, are characterized by poor water solubility. The same issue is shared by a number of natural molecules. Low solubility often results in limited or erratic bioavailability, which might impose higher doses to achieve a pharmacological effect, increasing the risk of toxicity and the waste of material. The reduction of drug particle size below 1 µm generates nanocrystals, which in the last several decades delivered the promise of increasing drug solubility and improving bioavailability. Nanocrystals can be dispersed in aqueous or non-aqueous media to produce nanosuspensions, stabilized by surfactants or polymers if necessary. Nanosuspensions, in addition to allowing high drug concentrations, have proved to be efficient in crossing a number of biological barriers, including the skin, the pulmonary epithelium, and the intestinal wall.
This Special Issue on Nanosuspensions for the Improvement of Drug Bioavailability will include original research and thematic reviews on any aspects related to the development of nanosuspensions.
Specifically, the Guest Editors welcome contributions focused on production processes and characterization methods, on the development of novel nanosuspensions, and on their assay in relevant in vitro/in vivo models. Expert opinions on clinical translation and speculative hypotheses on debated topics are also invited.
Prof. Dr. Francesco Lai
Dr. Michele Schlich
Dr. Rosa Pireddu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.