Special Issue "Novel Strategies for Enhancing Oral Bioavailability and/or Biopharmaceutics-Related Research"
Deadline for manuscript submissions: 31 October 2021.
Interests: biopharmaceutics (ADME and regulation on drug transporters and enzymes by vitamin D receptor); pharmacokinetics; nanoparticles; oral formulations
Interests: bioanalysis; biopharmaceutics; food/herb–drug interaction; pharmacokinetics
Special Issues and Collections in MDPI journals
Special Issue in Molecules: Method Development and Validation in Food and Pharmaceutical Analysis II
Special Issue in Molecules: Method Development and Validation in Food and Pharmaceutical Analysis III
Poor oral absorption is likely due to low aqueous or gastrointestinal solubility and poor intestinal membrane permeability. Additionally, drug candidates are often optimized with respect to intestinal and/or hepatic metabolic stability in the drug discovery and development stage, suggesting that the first-pass effect can govern oral bioavailability (BA) in vivo.
Thus, strategies to enhance the oral bioavailability of new drug candidates and prescription drugs are necessary. Various oral formulation technologies have been developed for poorly water-soluble drugs, such as nanosuspensions, solid dispersions, self-nanoemulsifying drug delivery systems (SNEDDSs), and so on. In addition, research on intestinal absorption to avoid efflux transporters such as P-glycoprotein, breast cancer resistance protein (BCRP), and multidrug-resistance-associated proteins (MRPs), using specific inhibitors; to utilize absorption-mediated influx transporters; and to increase passive diffusion via paracellular pathways by various formulations and/or nontoxic surfactants are scientifically meaningful to understand the mechanisms related to absorption.
This Special Issue focuses on novel strategies for enhancing oral bioavailability, such as oral formulations and/or biopharmaceutics-related approaches, to elucidate possible mechanisms responsible for poor oral bioavailability. We would like to invite original and review articles of novel and innovative research on drugs, drug candidates, nutrients, and other natural products in the fields of Pharmaceutics and Biopharmaceutics.
Prof. Dr. Han-Joo Maeng
Prof. Dr. In-Soo Yoon
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- oral absorption
- poorly water-soluble
- solid dispersions
- self-nanoemulsifying drug delivery system
- oral formulation technology
- natural products
- first pass effect