Plant Metabolites in Improving Drug’s Oral Bioavailability
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 382
Special Issue Editor
Interests: pharmaceutical development; host-guest complexes; medicinal and pharmaceutical chemistry; drug discovery; pharmacology; pharmaceutical formulation; toxicology; medicinal chemistry; biomedical materials
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is well-known that one of the most famous and convenient routes of drug introduction into the human body is oral administration. Nevertheless, this route is the most challenging and complex one, as it requires an opposite property such as water and lipid solubility in one chemical molecule for the drug to be successful. Of course, it is extremely hard for this to be applied in practice since most effective drugs are lipophilic compounds. This is usually the reason for their low bioavailability, together with other impacts, such as presystemic and first-pass metabolism. To overcome this problem, different approaches may be applied. One of them is the usage of different plant metabolites that can form supramolecular systems with drugs and increase their water solubility and oral bioavailability. In contrast to inert chemical carriers which are used mainly to improve water dissolution, such metabolites can additionally act directly on the intestinal epithelium and increase bioavailability via several mechanisms. The aim of this Special Issue is to highlight recent advances in this field, including in vivo and in vitro research.
Dr. Mikhail V. Khvostov
Guest Editor
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Keywords
- drug delivery
- plant metabolites
- bioavailability
- supramolecular complexes
- water solubility
- pharmacokinetics
- oral introduction
