Special Issue "Preclinical Evaluation of Lipid-Based Nanosystems (Volume II)"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Dr. Ana Catarina Silva
E-Mail Website
Guest Editor
UCIBIO/REQUIMTE, MEDTECH Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
Interests: lipid nanoparticles for nasal and cutaneous delivery; drug delivery systems; biopharmaceuticals; biological medicines; biosimilars
Special Issues and Collections in MDPI journals
Prof. Dr. José Manuel Sousa Lobo
E-Mail Website1 Website2
Guest Editor
UCIBIO, REQUIMTE, Laboratory of Pharmaceutical Technology, Centre of Research in Pharmaceutical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal
Interests: pharmaceutical technology; biopharmacy; pharmacokinetics; pharmaceutical nanotechnology
Special Issues and Collections in MDPI journals

Special Issue Information

Dear colleagues,

The use of lipid-based nanosystems, including lipid nanoparticles (solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)), nanoemulsions, and liposomes, is widespread. Several researchers have described the advantages of the different applications of these nanosystems. For instance, they can increase the targeting and bioavailability of drugs, improving their therapeutic effect. Their use in the cosmetic field is also promising, owing to the moisturizing properties and ability to protect labile cosmetic actives. Thus, it is surprising that only few lipid-based nanosystems have reached the market. This can be explained by the strict regulatory requirements of medicines and the occurrence of unexpected in vivo failure, which highlights the need to conduct more preclinical studies.

Current research is focused on testing the in vitro, ex vivo, and in vivo efficacy of lipid-based nanosystems to predict their clinical performance. However, there is a lack of method validation, which compromises comparison between different studies.

This special issue brings together the latest research and reviews that report preclinical studies in vitro, ex vivo, and in vivo using lipid-based nanosystems. Readers will find up-to-date information on the most common experiments that have been carried out to predict the clinical behavior of lipid-based nanosystems.

Dr. Ana Catarina Silva
Prof. Dr. José Manuel Sousa Lobo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • solid lipid nanoparticles
  • nanostructured lipid carriers
  • nanoemulsions
  • liposomes
  • in vitro studies
  • ex vivo studies
  • in vivo studies

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Published Papers

This special issue is now open for submission.
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