Chitosan-Based Nanocomposite Materials and Their Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (5 July 2023) | Viewed by 17435

Special Issue Editor

Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, Kafr El Sheikh City, Egypt
Interests: food safety; natural products; biopolymers; nanomaterials; antimicrobial agents; bioactive compounds; food-borne pathogens

Special Issue Information

Dear Colleagues,

Chitosan is a marvellous biopolymer resulting from chitin deacetylation. Chitosan could be extracted from diverse sources including crustacean waste, fungal biomass, and insect exoskeletons. The transformation of chitosan to nanoparticles gives it additional astonishing bioactive and reactive characteristics. Chitosan-based nanocomposites depend on the high ability of chitosan nanoparticles to cap, interact, synergise, and augment other active molecules/agents (such as drugs, anticancer compounds, phytochemicals, nanometals, polysaccharides; antimicrobial agents, therapeutic compounds, biopolymers, and their nano-formulations). The chitosan-based nanocomposite can be applied in numerous important fields (e.g., pharmaceutical, nutritional, environmental, agricultural, biomedical, drug delivery, antimicrobial, anticancer, tissue engineering, food industries, growth promotion, etc.).

The exploration/application into/of the chitosan biopolymer and its nanoparticles as functional compositing materials are highly attractive for their employments in food processing and preservation, environmental remediation, infection and immunological disease treatment, drug and therapeutic agent delivery, agricultural production, veterinary disciplines, and the healthcare of humans and animals.  

We are inviting your submissions to this Special Issue of the journal Polymers on “Chitosan-Based Nanocomposite Materials and Their Applications” to emphasize the latest advances in these interesting topics; submissions of research papers, review articles, and perspectives for this Special Issue are greatly welcomed.

Prof. Dr. Ahmed A. Tayel
Guest Editor

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Keywords

  •  chitosan extraction sources
  •  bioactivities
  •  nanopolymers
  •  antimicrobial
  •  anticancer
  •  environmental remediation
  •  drug carrying and delivery
  •  nanocomposites
  •  food safety and preservation
  •  diseases treatment
  •  agricultural applications
  •  veterinary medicines

Published Papers (8 papers)

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Research

17 pages, 3354 KiB  
Article
Pleiotropic Modulation of Chitooligosaccharides on Inflammatory Signaling in LPS-Induced Macrophages
by Wentong Hao, Kecheng Li, Song Liu, Huahua Yu, Pengcheng Li and Ronge Xing
Polymers 2023, 15(7), 1613; https://0-doi-org.brum.beds.ac.uk/10.3390/polym15071613 - 23 Mar 2023
Viewed by 1159
Abstract
Chitooligosaccharide (COS) is a green and non-toxic cationic carbohydrate that has attracted wide attention in recent years due to its anti-inflammatory activity. However, the anti-inflammatory mechanism of COS remains unclear. In this study, RNA-seq was used to investigate the integrated response of COS [...] Read more.
Chitooligosaccharide (COS) is a green and non-toxic cationic carbohydrate that has attracted wide attention in recent years due to its anti-inflammatory activity. However, the anti-inflammatory mechanism of COS remains unclear. In this study, RNA-seq was used to investigate the integrated response of COS to LPS-induced damage in macrophages. The results showed that the experimental group with COS had 2570 genes with significant differences compared to the model group, and that these genes were more enriched in inflammatory and immune pathways. The KEGG results showed that COS induces the pleiotropic modulation of classical inflammatory pathways, such as the Toll-like receptor signaling pathway, NF-κB, MAPK, etc. Based on the RNA-seq data and the RT-qPCR, as well as the WB validation, COS can significantly upregulate the expression of membrane receptors, such as Tlr4, Tlr5, and MR, and significantly inhibits the phosphorylation of several important proteins, such as IκB and JNK. Overall, this study offers deep insights into the anti-inflammatory mechanism and lays the foundation for the early application of COS as an anti-inflammatory drug. Full article
(This article belongs to the Special Issue Chitosan-Based Nanocomposite Materials and Their Applications)
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14 pages, 4209 KiB  
Article
Interactions between Soybean Trypsin Inhibitor and Chitosan in an Aqueous Solution
by Yihao Zhang, Ruijia Liu, He Li, You Li and Xinqi Liu
Polymers 2023, 15(7), 1594; https://0-doi-org.brum.beds.ac.uk/10.3390/polym15071594 - 23 Mar 2023
Cited by 3 | Viewed by 1086
Abstract
Supramolecular structures obtained from protein–polysaccharide association may be applied to encapsulate bioactive compounds or to improve the physical stability and texture properties of colloid–based products. In this study, the interaction of 0.1 wt% soybean trypsin inhibitor (STI) with different concentrations of chitosan (CS) [...] Read more.
Supramolecular structures obtained from protein–polysaccharide association may be applied to encapsulate bioactive compounds or to improve the physical stability and texture properties of colloid–based products. In this study, the interaction of 0.1 wt% soybean trypsin inhibitor (STI) with different concentrations of chitosan (CS) in aqueous solutions was investigated under different pH by the analysis of state diagram, turbidity, zeta potential, spectroscopy, and microstructure; the protective effect of STI–CS complex coacervates on STI stability in simulated gastric juice was also discussed. The results suggested that interactions between STI and CS could form soluble/insoluble complexes mainly through hydrophobic interactions (pH 4.0) or electrostatic interactions (pH 6.0). The CD spectra showed that the secondary structure of STI did not change significantly when CS with the same charge was mixed with STI, and the secondary structure of STI was slightly changed when CS with the opposite charge was mixed with STI. Simulated gastric digestion experiments showed that the complex formed by non-covalent bonding had a protective effect on the active protein. This study provides information about the effect of different CS concentrations and pH values on the formation of complexes of CS and STI in an aqueous solution and provides theoretical references for the construction of supramolecular-structured carrier substances based on CS and STI. Full article
(This article belongs to the Special Issue Chitosan-Based Nanocomposite Materials and Their Applications)
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15 pages, 5741 KiB  
Article
Fabrication of Bilayer Magnetically Actuated L-Shaped Microrobot Based on Chitosan via Photolithography
by Haoying Wang, Xiaoxia Song, Junfeng Xiong and U Kei Cheang
Polymers 2022, 14(24), 5509; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14245509 - 15 Dec 2022
Cited by 3 | Viewed by 1626
Abstract
Magnetically actuated microrobots showed increasing potential in various fields, especially in the biomedical area, such as invasive surgery, targeted cargo delivery, and treatment. However, it remains a challenge to incorporate biocompatible natural polymers that are favorable for practical biomedical applications. In this work, [...] Read more.
Magnetically actuated microrobots showed increasing potential in various fields, especially in the biomedical area, such as invasive surgery, targeted cargo delivery, and treatment. However, it remains a challenge to incorporate biocompatible natural polymers that are favorable for practical biomedical applications. In this work, bilayer magnetic microrobots with an achiral planar design were fabricated using a biocompatible natural polymer and Fe3O4 nanoparticles through the photolithography by applying the layer-by-layer method. The microrobots consisted of a magnetic bottom layer and a photo-crosslinked chitosan top layer. The SEM results showed that the microrobot processed the L-shaped planar structure with the average width, length, and thickness of 99.18 ± 5.11 μm, 189.56 ± 11.37 μm, and 23.56 ± 4.08 μm, respectively. Moreover, microrobots actuated using a three-dimensional (3D) Helmholtz coil system was characterized and reached up to an average maximum velocity of 325.30 μm/s and a step-out frequency of 14 Hz. Furthermore, the microrobots exhibited excellent cell biocompatibility towards L929 cells in the CCK-8 assay. Therefore, the development of bi-layered chitosan-based microrobots offers a general solution for using magnetic microrobots in biomedical applications by providing an easy-to-fabricate, highly mobile microrobotic platform with the incorporation of biocompatible natural polymers for enhanced biocompatibility. Full article
(This article belongs to the Special Issue Chitosan-Based Nanocomposite Materials and Their Applications)
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15 pages, 5310 KiB  
Article
A PEGylated Chitosan as Gel Polymer Electrolyte for Lithium Ion Batteries
by Anqi Wang, Yue Tu, Sijie Wang, Hongbing Zhang, Feng Yu, Yong Chen and De Li
Polymers 2022, 14(21), 4552; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14214552 - 27 Oct 2022
Cited by 7 | Viewed by 2445
Abstract
Due to their safety and sustainability, polysaccharides such as cellulose and chitosan have great potential to be the matrix of gel polymer electrolytes (GPE) for lithium-based batteries. However, they easily form hydrogels due to the large numbers of hydrophilic hydroxyl or amino functional [...] Read more.
Due to their safety and sustainability, polysaccharides such as cellulose and chitosan have great potential to be the matrix of gel polymer electrolytes (GPE) for lithium-based batteries. However, they easily form hydrogels due to the large numbers of hydrophilic hydroxyl or amino functional groups within their macromolecules. Therefore, a polysaccharide-based amphiphilic gel, or organogel, is urgently necessary to satisfy the anhydrous requirement of lithium ion batteries. In this study, a PEGylated chitosan was initially designed using a chemical grafting method to make an GPE for lithium ion batteries. The significantly improved affinity of PEGylated chitosan to organic liquid electrolyte makes chitosan as a GPE for lithium ion batteries possible. A reasonable ionic conductivity (1.12 × 10−3 S cm−1) and high lithium ion transport number (0.816) at room temperature were obtained by replacing commercial battery separator with PEG-grafted chitosan gel film. The assembled Li/GPE/LiFePO4 coin cell also displayed a high initial discharge capacity of 150.8 mA h g−1. The PEGylated chitosan-based GPE exhibits great potential in the field of energy storage. Full article
(This article belongs to the Special Issue Chitosan-Based Nanocomposite Materials and Their Applications)
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15 pages, 1854 KiB  
Article
Correlation between Antioxidant and Anti-Osteoporotic Activities of Shilajit Loaded into Chitosan Nanoparticles and Their Effects on Osteoporosis in Rats
by Fawzia A. Alshubaily and Ebtihaj J. Jambi
Polymers 2022, 14(19), 3972; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14193972 - 23 Sep 2022
Cited by 5 | Viewed by 1913
Abstract
Various therapies for osteoporosis successfully reduce bone loss and fractures, but they mostly do not contribute to new bone structures and adversely affect patients. Shilajit is a natural mineral substance comprised of multi-components, with proved efficacy to improve immunity, antioxidant activity, and disease [...] Read more.
Various therapies for osteoporosis successfully reduce bone loss and fractures, but they mostly do not contribute to new bone structures and adversely affect patients. Shilajit is a natural mineral substance comprised of multi-components, with proved efficacy to improve immunity, antioxidant activity, and disease resistance. In the present study, various effects of shilajit water extract (SWE) on bone development and its management were determined in experimental glucocorticoid-induced osteoporotic rats. The fabrication of nanochitosan (NCT) and NCT conjugation with SWE were conducted and evaluated as enhanced formulations for treating osteoporosis. NCT and SWE/NCT had mean particle diameters of 196.4 and 248.4 nm, respectively, with high positivity charging and stability. The biochemical and anti-osteoporotic effects of SWE and SWE/NCT conjugates were investigated on different groups of compromised rats. Five groups each including six adult albino female rats were formed and treated for a duration of eight weeks with SWE and SWE/NCT conjugate. Significantly improved serum calcium, phosphorus, osteocalcin, and calcitonin levels but decreased hydrogen peroxide, IL-6, and antioxidant biomarkers were recorded in all SWE- and SWE/NCT-treated groups; the SWE/NCT treatment was most effectual treatment. These results suggest that SWE and SWE/NCT may cause anti-osteoporotic activity by reducing oxidative stress, IL-6, and H2O2 while restoring antioxidant levels. The conjugation of SWE onto NCT is highly recommended for augmenting their activities. Full article
(This article belongs to the Special Issue Chitosan-Based Nanocomposite Materials and Their Applications)
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19 pages, 2400 KiB  
Article
Application of Nanocomposites from Bees Products and Nano-Selenium in Edible Coating for Catfish Fillets Biopreservation
by Dareen M. Youssef, Fawzia A. Alshubaily, Ahmed A. Tayel, Mousa A. Alghuthaymi and Mahmoud A. Al-Saman
Polymers 2022, 14(12), 2378; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14122378 - 12 Jun 2022
Cited by 11 | Viewed by 2090
Abstract
Bee products, e.g., chitosan and propolis (Pro), have extraordinary importance in many disciplines including food biopreservation. Fish meat is highly susceptible to vast spoilage, especially catfish (Clarias gariepinus) products. The current work involved the extraction of bees’ chitosan nanoparticles (BCht), Pro, [...] Read more.
Bee products, e.g., chitosan and propolis (Pro), have extraordinary importance in many disciplines including food biopreservation. Fish meat is highly susceptible to vast spoilage, especially catfish (Clarias gariepinus) products. The current work involved the extraction of bees’ chitosan nanoparticles (BCht), Pro, Pro-mediated SeNPs and their composites, to evaluate them as potential antimicrobial and preservative nano-compounds, for the preservation of catfish fillets and augment their quality. BCht was extracted from bees (Apis mellifera) corpses and had a 151.9 nm mean particle diameter. The Pro was used for biosynthesis of SeNPs, which had 11.2 nm mean diameters. The entire compounds/composites exhibited powerful antibacterial acts against Escherichia coli, Staphylococcus aureus and Salmonella typhimurium, where S aureus had the uppermost resistance. BCht/Pro/SeNPs were the most forceful toward all bacterial strains. The constructed edible coatings (ECs) from produced compounds/composites (BCht, Pro, Pro/SeNPs, Pro/BCht and BCht/Pro/SeNPs) had elevated efficiency for preserving catfish fillets during cold storages for 7 days. The microbiological (total counts, psychrophilic bacteria, yeast and molds), spoilage chemical parameters (TVB-N, TBARS) and sensorial attributes (appearance, odor, color, overall quality) of ECs-treated fillets indicated the nanocomposite’s efficiency for protecting the fish from microbial growth, the progress of chemical spoilage indicators and maintaining the sensorial quality of treated stored fillets. The most effective nanocomposite for maintaining the entire fillet’s quality was the BCht/Pro/SeNP. The based ECs on BNCt, Pro/SeNPs and their nanocomposites could be endorsed for prospective employment in the biopreservation of various seafoods. Full article
(This article belongs to the Special Issue Chitosan-Based Nanocomposite Materials and Their Applications)
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13 pages, 1439 KiB  
Article
Innovative Approach for Controlling Black Rot of Persimmon Fruits by Means of Nanobiotechnology from Nanochitosan and Rosmarinic Acid-Mediated Selenium Nanoparticles
by Mohamed F. Salem, Ahmed A. Tayel, Fahad Mohammed Alzuaibr and Ramadan A. Bakr
Polymers 2022, 14(10), 2116; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14102116 - 23 May 2022
Cited by 7 | Viewed by 2814
Abstract
The protection of persimmon fruits (Diospyros kaki L.) from postharvest fungal infestation with Alternaria alternata (A. alternate; black rot) is a major agricultural and economic demand worldwide. Edible coatings (ECs) based on biopolymers and phytocompounds were proposed to maintain fruit [...] Read more.
The protection of persimmon fruits (Diospyros kaki L.) from postharvest fungal infestation with Alternaria alternata (A. alternate; black rot) is a major agricultural and economic demand worldwide. Edible coatings (ECs) based on biopolymers and phytocompounds were proposed to maintain fruit quality, especially with nanomaterials’ applications. Chitosan nanoparticles (NCt), rosmarinic acid bio-mediated selenium nanoparticles (RA/SeNPs) and their composites were produced, characterized and evaluated as ECs for managing persimmon black rot. The constructed NCt, RA/SeNPs and NCt/RA/SeNPs composite had diminished particles’ size diameters. The ECs solution of 1% NCt and NCt/RA/SeNPs composite led to a significant reduction of A. alternata radial growth in vitro, with 77.4 and 97.2%, respectively. The most powerful ECs formula contained 10 mg/mL from NCt/RA/SeNPs composite, which significantly reduced fungal growth than imazalil fungicide. The coating of persimmon with nanoparticles-based ECs resulted in a significant reduction of black rot disease severity and incidence in artificially infected fruits; the treatment with 1% of NCt/RA/SeNPs could completely (100%) hinder disease incidence and severity in coated fruits, whereas imazalil reduced them by 88.6 and 73.4%, respectively. The firmness of fruits is greatly augmented after ECs treatments, particularly with formulated coatings with 1% NCt/RA/SeNPs composite, which maintain fruits firmness by 85.7%. The produced ECs in the current study, based on NCt/RA/SeNPs composite, are greatly recommended as innovatively constructed human-friendly matrix to suppress the postharvest destructive fungi (A. alternata) and maintain the shelf-life and quality of persimmon fruits. Full article
(This article belongs to the Special Issue Chitosan-Based Nanocomposite Materials and Their Applications)
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12 pages, 1822 KiB  
Article
Preparation and Characterization of Bioactive Chitosan Film Loaded with Cashew (Anacardium occidentale) Leaf Extract
by Khursheed Ahmad Shiekh, Mooksupang Liangpanth, Siriporn Luesuwan, Rinlanee Kraisitthisirintr, Kittaporn Ngiwngam, Saroat Rawdkuen, Pornchai Rachtanapun, Thomas Karbowiak and Wirongrong Tongdeesoontorn
Polymers 2022, 14(3), 540; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14030540 - 28 Jan 2022
Cited by 7 | Viewed by 3323
Abstract
Chitosan is a biopolymer known for its rapid biodegradability and film-forming properties. This research aimed to synthesize and characterize chitosan films loaded with cashew leaf extract (CLE) obtained from immature and mature cashew leaves via aqueous and 70% ethanolic extraction methods. Freeze-dried CLE [...] Read more.
Chitosan is a biopolymer known for its rapid biodegradability and film-forming properties. This research aimed to synthesize and characterize chitosan films loaded with cashew leaf extract (CLE) obtained from immature and mature cashew leaves via aqueous and 70% ethanolic extraction methods. Freeze-dried CLE samples were dissolved in 50% dimethyl sulfoxide for in vitro analysis and chitosan film preparation. The total phenolic content of mature cashew leaves extracted in ethanol (MECLE) showed higher free radicle scavenging activity by a 2,2-diphenyl-1-picrylhydrazyl assay than the other extracts (p < 0.05). MECLE displayed a lower minimal inhibitory concentration, minimum fungal concentration, and higher zone of inhibition against Aspergillus niger compared to the other treatments (p < 0.05). Film-forming solutions were prepared using 2% chitosan, 2% chitosan with 5% mature cashew leaves extracted in deionized water (MACLE) (w/v), and 2% chitosan with 5% MECLE (w/v), respectively, to cast films. Of these, 2% chitosan (CH) with 5% MECLE (CH-MECLE-5) displayed the highest thickness and water vapor transmission rate, water vapor permeability, and oxygen transmission rate when compared to other film samples (p < 0.05). The CH-MECLE-5 film showed the highest inhibition zone of A. niger compared to the control and treated films (p < 0.05). The lightness (L*) of the CH-MECLE-5 film decreased with increment in b* values, which represented the yellow color of the film. In addition, two-photon microscopy revealed a uniform distribution via the auto-fluorescent 3D structure of MECLE in the CH-MECLE-5 film. Therefore, chitosan combined with 5% MECLE may be a potential bioactive and eco-friendly packaging film. Full article
(This article belongs to the Special Issue Chitosan-Based Nanocomposite Materials and Their Applications)
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