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Polymers
Special Issues
Complex Diagnostics of Multifunctional Polymer Nanostructures and Biomaterials
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Complex Diagnostics of Multifunctional Polymer Nanostructures and Biomaterials

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Smart and Functional Polymers".

Deadline for manuscript submissions: closed (5 April 2023) | Viewed by 6977

Special Issue Editors

Dr. Alexey V. Nashchekin

E-Mail Website
Guest Editor
Ioffe Institute, Saint-Petersburg, Russia
Interests: scanning electron microscopy; FTIR spectroscopy; e-beam lithography; fullerenes; photonic crystals; composite materials; localized surface plasmon resonance; plasmonic structures/nanoparticles; graphene; biopolymers; biosensors
Prof. Dr. Sergey G. Lushnikov

E-Mail Website
Guest Editor
Ioffe Institute, Saint-Petersburg, Russia
Interests: inelastic light scattering; neutron scattering; calorimetry; dielectric spectroscopy; phase transformations; structure phase transition; lattice dynamics; biopolymers; aggregations; fibrillations; acoustic phonons; ferroelectrics; multiferroics; glass transitions

Special Issue Information

Dear Colleagues,

The active development of biological materials for a wide range of biomedical applications in recent years requires the development of new diagnostic approaches for their study, optimization of existing methods, and the development of complex diagnostic solutions that simultaneously allow excitation and detection of signals of various natures: electrical, optical, magnetic, etc.

This Special Issue is mainly aimed at identifying the existing urgent problems and hot spots of modern biomedicine, physics and chemistry in the field of polymer and biological materials with a description of ways to overcome the revealed problems by applying a wide range of methods implemented on the basis of modern diagnostic equipment.

Special attention should be paid to investigations of multifunctional nanostructured polymers, the processes of fibrillation/destruction of polymers in various aggressive media, model solutions analogous to human biological fluids and the identification of new properties of synthesized/modified biomaterials, including the use of new materials for the functionalization of biosensor devices.

Dr. Alexey V. Nashchekin
Prof. Dr. Sergey G. Lushnikov
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • complex diagnostic methods
  • polymers
  • nanostructured materials
  • biodegradable polymers
  • biocompatible composites
  • biosensors
  • graphene

Published Papers (3 papers)

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Research

15 pages, 3070 KiB  
Article
Effect of Functionalization of the Polycaprolactone Film Surface on the Mechanical and Biological Properties of the Film Itself
by Yuliya Nashchekina, Alina Chabina, Olga Moskalyuk, Irina Voronkina, Polina Evstigneeva, Gleb Vaganov, Alexey Nashchekin, Vladimir Yudin and Nataliya Mikhailova
Polymers 2022, 14(21), 4654; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14214654 - 01 Nov 2022
Cited by 3 | Viewed by 1587
Abstract
The lack of suitable functional groups for cell adhesion on the surface of Polycaprolactone (PCL) is one of the main limitations in order to use PCL for biomedical applications. The aim of this research is to modify the PCL film surface using arginine, [...] Read more.
The lack of suitable functional groups for cell adhesion on the surface of Polycaprolactone (PCL) is one of the main limitations in order to use PCL for biomedical applications. The aim of this research is to modify the PCL film surface using arginine, via an aminolysis reaction. In this regard, after PCL films formation by casting method, they were immersed in arginine solutions of various concentration at room temperature or then heated to 40 °C and in the presence of isopropanol or without it. To assess the structure of the modified surface, its wettability, and mechanical properties, methods of measuring the contact angle and the strip tensile test were used, and to compare the degree of attachment and the rate of cell proliferation, the method of fluorescent staining of cultured cells was used. The change in protein synthesis by cells on the modified surface was assessed using Western blotting. The results obtained show that the treatment of PCL films with an aqueous solution of arginine at room temperature for 1 day increases the hydrophilicity of the surface. Wherein surface modification led to a two-fold decrease of mechanical strength and flow stress, but elongation increase by about 30% for PCL films after modification in 0.5 M aqueous arginine solution at room temperature. Moreover, cell attachment and proliferation, as well as collagen synthesis, were significantly enhanced after arginine modification. The proposed simple and effective method for modifying PCL films with arginine significantly expands the possibilities for developing biocompatible scaffolds for tissue engineering. Full article
(This article belongs to the Special Issue Complex Diagnostics of Multifunctional Polymer Nanostructures and Biomaterials)
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24 pages, 6685 KiB  
Article
Domain Structure, Thermal and Mechanical Properties of Polycaprolactone-Based Multiblock Polyurethane-Ureas under Control of Hard and Soft Segment Lengths
by Alexander N. Bugrov, Yulia E. Gorshkova, Elena M. Ivan’kova, Gennady P. Kopitsa, Alina A. Pavlova, Elena N. Popova, Valentina E. Smirnova, Ruslan Y. Smyslov, Valentin M. Svetlichnyi, Gleb V. Vaganov and Boris V. Vasil’ev
Polymers 2022, 14(19), 4145; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14194145 - 03 Oct 2022
Cited by 3 | Viewed by 2235
Abstract
A series of multiblock polyurethane-ureas (PUU) based on polycaprolactone diol (PCL) with a molecular mass of 530 or 2000 g/mol, as well as hard segments of different lengths and structures, were synthesized by the step-growth polymerization method. The chemical structure of the synthesized [...] Read more.
A series of multiblock polyurethane-ureas (PUU) based on polycaprolactone diol (PCL) with a molecular mass of 530 or 2000 g/mol, as well as hard segments of different lengths and structures, were synthesized by the step-growth polymerization method. The chemical structure of the synthesized multiblock copolymers was confirmed by IR- and NMR-spectroscopy. Differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) were used to determine the relaxation and phase transition temperatures for the entire series of the obtained PUU. The X-ray diffraction (XRD) method made it possible to identify PUU compositions in which the crystallizability of soft segments (SS) is manifested due to their sufficient length for self-organization and structuring. Visualization of the crystal structure and disordering of the stacking of SS with an increase in their molecular mobility during heating are shown using optical microscopy. The change in the size of the hard phase domains and the value of the interdomain distance depending on the PCL molecular mass, as well as the length and structure of the hard block in the synthesized PUU, were analyzed using small-angle X-ray scattering (SAXS) and small-angle neutron scattering (SANS). The evolution of the domain structure upon passing through the melting and crystallization temperatures of PUU soft blocks was studied using SANS. The studies carried out made it possible to reveal the main correlations between the chemical structure of the synthesized PUU and their supramolecular organization as well as thermal and mechanical properties. Full article
(This article belongs to the Special Issue Complex Diagnostics of Multifunctional Polymer Nanostructures and Biomaterials)
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21 pages, 3796 KiB  
Article
Interfaces Based on Laser-Structured Arrays of Carbon Nanotubes with Albumin for Electrical Stimulation of Heart Cell Growth
by Alexander Yu. Gerasimenko, Evgeny Kitsyuk, Uliana E. Kurilova, Irina A. Suetina, Leonid Russu, Marina V. Mezentseva, Aleksandr Markov, Alexander N. Narovlyansky, Sergei Kravchenko, Sergey V. Selishchev and Olga E. Glukhova
Polymers 2022, 14(9), 1866; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14091866 - 02 May 2022
Cited by 7 | Viewed by 2381
Abstract
Successful formation of electronic interfaces between living cells and electronic components requires both good cell viability and performance level. This paper presents a technology for the formation of nanostructured arrays of multi-walled carbon nanotubes (MWCNT) in biopolymer (albumin) layer for higher biocompatibility. The [...] Read more.
Successful formation of electronic interfaces between living cells and electronic components requires both good cell viability and performance level. This paper presents a technology for the formation of nanostructured arrays of multi-walled carbon nanotubes (MWCNT) in biopolymer (albumin) layer for higher biocompatibility. The layer of liquid albumin dispersion was sprayed on synthesized MWCNT arrays by deposition system. These nanostructures were engineered using the nanosecond pulsed laser radiation mapping in the near-IR spectral range (λ = 1064 nm). It was determined that the energy density of 0.015 J/cm2 provided a sufficient structuring of MWCNT. The structuring effect occurred during the formation of C–C bonds simultaneously with the formation of a cellular structure of nanotubes in the albumin matrix. It led to a decrease in the nanotube defectiveness, which was observed during the Raman spectroscopy. In addition, laser structuring led to a more than twofold increase in the electrical conductivity of MWCNT arrays with albumin (215.8 ± 10 S/m). Successful electric stimulation of cells on the interfaces with the system based on a culture plate was performed, resulting in the enhanced cell proliferation. Overall, the MWCNT laser-structured arrays with biopolymers might be a promising material for extended biomedical applications. Full article
(This article belongs to the Special Issue Complex Diagnostics of Multifunctional Polymer Nanostructures and Biomaterials)
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