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Polymers
Special Issues
Molecularly Imprinted Polymer (MIP) Materials for Separation, Purification and Sensing
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Molecularly Imprinted Polymer (MIP) Materials for Separation, Purification and Sensing

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Smart and Functional Polymers".

Deadline for manuscript submissions: closed (25 July 2022) | Viewed by 11187

Special Issue Editors

Prof. Dr. Jianming Pan

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Guest Editor
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China
Interests: molecular imprinting and smart materials; molecular identification separation; construction of droplet reactor
Special Issues, Collections and Topics in MDPI journals
Dr. Xiangheng Niu

E-Mail Website
Guest Editor
School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China
Interests: nanozymes; environmental detection; food analysis; biochemical sensing
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Zhong Zhang

E-Mail Website
Guest Editor
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710062, China
Interests: design of molecularly imprinted sensor with fluorescent material for identification and sensing applications

Special Issue Information

Dear Colleagues,

Since the 1970s, when the molecular imprinting technique (MIT) was developed to create selective recognition sites in synthetic polymers, the past decades have seen a birth–growth–prosperity period for this technique. With tailor-made binding sites that are complementary to template molecules in size, shape, and functional groups, molecularly imprinted polymers (MIPs) are considered a class of ‘artificial antibodies’ to recognize desired targets with good specificity. Various advanced imprinting techniques have been explored to fabricate smart MIPs with desired performance. With the features of structure predictability, recognition specificity, and application universality, MIPs have found extensive use in separation, purification, sensing, catalysis, biomedicine, and so on. In spite of these advances, some recognized challenges exist, which require further efforts from multidisciplinary areas to push MIT and MIPs to another boom period. In this Special Issue entitled ‘Molecularly Imprinted Polymer (MIP) Materials for Separation, Purification, and Sensing’, Polymers aims to report original articles that present the latest progress in the design, fabrication, characterization, and property exploration of MIP materials and their applications in separation, purification, and analytical detection. Critical reviews that reflect current hotspots, new challenges, and future perspectives of MIT and MIP materials are particularly welcome.

Prof. Dr. Jianming Pan
Prof. Dr. Xiangheng Niu
Prof. Dr. Zhong Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecularly imprinted polymers
  • molecular imprinting technique
  • separation
  • purification
  • sensing

Published Papers (4 papers)

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Review

22 pages, 796 KiB  
Review
A Review: Using Multiple Templates for Molecular Imprinted Polymer: Is It Good?
by Niky Murdaya, Anastasya Leatemia Triadenda, Driyanti Rahayu and Aliya Nur Hasanah
Polymers 2022, 14(20), 4441; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14204441 - 20 Oct 2022
Cited by 16 | Viewed by 3081
Abstract
A multi-template molecularly imprinting polymer (MT-MIP) strategy has been proposed and is increasingly utilised to synthesise MIP with multiple recognition sites in a single polymer using multiple target species as templates. This approach can expand MIP applications for simultaneous recognition and extraction of [...] Read more.
A multi-template molecularly imprinting polymer (MT-MIP) strategy has been proposed and is increasingly utilised to synthesise MIP with multiple recognition sites in a single polymer using multiple target species as templates. This approach can expand MIP applications for simultaneous recognition and extraction of more than one analyte. The advantages of MT-MIP are simultaneous analyte extraction in one process, lower solvent consumption, cost-effectiveness, and short analysis time. The use of multiple templates to prepare a MIP reduces the effort required to prepare different MIPs for different analytes separately. Although there are many studies about developing MT-MIP, there are no review articles that discuss the success rate of MT-MIP. Therefore, in this review, we summarise MT-MIP synthesis, including the polymerisation method being used, the important factors that affect the quality of MT-MIP, and MT-MIP applications. MT-MIP has great potential in chemical isolation and analysis. MT-MIP produces a product that has good sensitivity, selectivity, and reusability. Furthermore, many templates, functional monomers, and crosslinkers can be formulated as MT-MIP and have a high success rate. This is evidenced by the good values of the maximum absorption capacity (Qmax), imprinting factor (IF), and reusability. We expect that the evidence presented in this review can encourage additional research on the development and application of MT-MIP. Full article
(This article belongs to the Special Issue Molecularly Imprinted Polymer (MIP) Materials for Separation, Purification and Sensing)
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17 pages, 1185 KiB  
Review
Dual-Functional Monomer MIPs and Their Comparison to Mono-Functional Monomer MIPs for SPE and as Sensors
by Angela Alysia Elaine, Steven Imanuel Krisyanto and Aliya Nur Hasanah
Polymers 2022, 14(17), 3498; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14173498 - 26 Aug 2022
Cited by 4 | Viewed by 1852
Abstract
A molecularly imprinted polymer (MIP) is a synthetic polymer that has characteristics such as natural receptors which are able to interact and bind to a specific molecule that is used as a template in the MIP polymerization process. MIPs have been widely developed [...] Read more.
A molecularly imprinted polymer (MIP) is a synthetic polymer that has characteristics such as natural receptors which are able to interact and bind to a specific molecule that is used as a template in the MIP polymerization process. MIPs have been widely developed because of the need for more selective, effective, and efficient methods for sample preparation, identification, isolation, and separation. The MIP compositions consist of a template, monomer, crosslinker, initiator, and porogenic solvent. Generally, MIPs are only synthesized using one type of monomer (mono-functional monomer); however, along with the development of MIPs, MIPs began to be synthesized using two types of monomers to improve the performance of MIPs. MIPs used for identification, separation, and molecular analysis have the most applications in solid-phase extraction (SPE) and as biochemical sensors. Until now, no review article has discussed the various studies carried out in recent years in relation to the synthesis of dual-functional monomer MIPs. This review is necessary, as an improvement in the performance of MIPs still needs to be explored, and a dual-functional monomer strategy is one way of overcoming the current performance limitations. In this review article, we discuss the techniques commonly used in the synthesis of dual-functional monomer MIPs, and the use of dual-functional monomer MIPs as sorbents in the MI-SPE method and as detection elements in biochemical sensors. The application of dual-functional monomer MIPs showed better selectivity and adsorption capacity in these areas when compared to mono-functional monomer MIPs. However, the combination of functional monomers must be selected properly, in order to achieve an effective synergistic effect and produce the ideal MIP characteristics. Therefore, studies regarding the synergistic effect of the MIP combination still need to be carried out to obtain MIPs with superior characteristics. Full article
(This article belongs to the Special Issue Molecularly Imprinted Polymer (MIP) Materials for Separation, Purification and Sensing)
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25 pages, 1157 KiB  
Review
Factors Affecting the Analytical Performance of Magnetic Molecularly Imprinted Polymers
by Nur Masyithah Zamruddin, Herman Herman, Laode Rijai and Aliya Nur Hasanah
Polymers 2022, 14(15), 3008; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14153008 - 25 Jul 2022
Cited by 4 | Viewed by 1982
Abstract
During the last few years, separation techniques using molecular imprinting polymers (MIPs) have been developed, making certain improvements using magnetic properties. Compared to MIP, Magnetic molecularly imprinted polymers (MMIPs) have high selectivity in sample pre-treatment and allow for fast and easy isolation of [...] Read more.
During the last few years, separation techniques using molecular imprinting polymers (MIPs) have been developed, making certain improvements using magnetic properties. Compared to MIP, Magnetic molecularly imprinted polymers (MMIPs) have high selectivity in sample pre-treatment and allow for fast and easy isolation of the target analyte. Its magnetic properties and good extraction performance depend on the MMIP synthesis step, which consists of 4 steps, namely magnetite manufacture, magnetic coating using modified components, polymerization and template desorption. This review discusses the factors that will affect the performance of MMIP as a selective sorbent at each stage. MMIP, using Fe3O4 as a magnetite core, showed strong superparamagnetism; it was prepared using the co-precipitation method using FeCl3·6H2O and FeCl2·H2O to obtain high magnetic properties, using NH4OH solution added for higher crystallinity. In magnetite synthesis, the use of a higher temperature and reaction time will result in a larger nanoparticle size and high magnetization saturation, while a higher pH value will result in a smaller particle size. In the modification step, the use of high amounts of oleic acid results in smaller nanoparticles; furthermore, determining the correct molar ratio between FeCl3 and the shielding agent will also result in smaller particles. The next factor is that the proper ratio of functional monomer, cross-linker and solvent will improve printing efficiency. Thus, it will produce MMIP with high selectivity in sample pre-treatment. Full article
(This article belongs to the Special Issue Molecularly Imprinted Polymer (MIP) Materials for Separation, Purification and Sensing)
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24 pages, 1957 KiB  
Review
Magnetic Molecularly Imprinted Polymers: An Update on Their Use in the Separation of Active Compounds from Natural Products
by Marisa Dwi Ariani, Ade Zuhrotun, Panagiotis Manesiotis and Aliya Nur Hasanah
Polymers 2022, 14(7), 1389; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14071389 - 29 Mar 2022
Cited by 18 | Viewed by 3475
Abstract
During the last few years, separation techniques using molecularly imprinted polymers (MIPs) have been developed, making breakthroughs using magnetic properties. Compared to conventional MIPs, magnetic molecularly imprinted polymers (MMIPs) have advantages in sample pretreatment due to their high specificity and selectivity towards analytes [...] Read more.
During the last few years, separation techniques using molecularly imprinted polymers (MIPs) have been developed, making breakthroughs using magnetic properties. Compared to conventional MIPs, magnetic molecularly imprinted polymers (MMIPs) have advantages in sample pretreatment due to their high specificity and selectivity towards analytes as a result of their larger specific surface areas and highly accessible specific binding sites. The techniques of isolation of active compounds from natural products usually require very long process times and low compound yields. When MMIPs are used in sample separation as Solid Phase Extraction (SPE) sorbents, the MMIPs are introduced into the dissolved sample and spread evenly, and they form bonds between the analyte and the MMIPs, which are then separated from the sample matrix using an external magnetic field. This process of separating analytes from the sample matrix makes the separation technique with MMIPs very simple and easy. This review discusses how to synthesize MMIPs, which factors must be considered in their synthesis, and their application in the separation of active compounds from natural products. MMIPs with magnetic core-shells made by co-precipitation can be a good choice for further development due to the high synthesis yield. Further optimization of the factors affecting the size and distribution of magnetic core-shell particles can obtain higher synthesis yields of MMIPs with higher adsorption capacity and selectivity. Thus, they can isolate target compounds from natural plants in high yields and purity. Full article
(This article belongs to the Special Issue Molecularly Imprinted Polymer (MIP) Materials for Separation, Purification and Sensing)
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