Polymer-Based Materials for Ophthalmic Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 3362

Special Issue Editor


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Guest Editor
Graduate Institute of Biomedical Engineering, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Taoyuan 33302, Taiwan
Interests: stimuli-responsive polymers; biopolymers; polymeric biomaterials; nanoscale polymers; polymer composites

Special Issue Information

Dear Colleagues,

Polymers have recently attracted a great deal of interest for their use in ophthalmic applications toward efficient management of the health, physiology, and diseases of the eye. Owing to their simplicity of processing and capability of incorporating with diverse materials to promote specific functions, polymers can be manipulated to meet particular demands in modern ophthalmic devices as well as drug platforms. Current applications of polymers in ophthalmology include in contact lens, artificial corneas, artificial lacrimal ducts, vitreous substitutes, intraocular lens, and drug delivery systems. Both synthetic and natural polymers have been exploited in ophthalmic applications in a variety of forms such as hydrogels, fibers, membranes, tablets, suspensions, nanosystems, and implants.

This Special Issues invites state-of-the-art reviews and original research articles on the development of polymer-based materials for ophthalmic applications. This includes but is not limited to investigations on the effects of synthetic parameters, structure, biocompatibility, toxicity, vision correction and improvement, and therapeutic performance. Submissions involving novel applications, new designs, or innovative characterization methods are also welcomed.

Contributions can cover the following topics (but are not limited to these):

  • Materials, processes, and ocular biocompatibility/toxicity;
  • Vision correction and improvement;
  • Novel polymers for practical uses in ophthalmology;
  • Structural and functional design for ophthalmic applications;
  • Polymeric nanosystems;
  • Polymer-based drug delivery systems.

Prof. Dr. Jui-Yang Lai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biopolymers
  • Synthetic polymers
  • Polymeric nanoparticles
  • Biological characterization
  • Nanomedicine
  • Ocular implants
  • Contact lens
  • Drug delivery systems

Published Papers (1 paper)

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Research

19 pages, 5515 KiB  
Article
Nanoparticles Loaded Thermoresponsive In Situ Gel for Ocular Antibiotic Delivery against Bacterial Keratitis
by Muhammad Naseer Abbas, Saeed Ahmad Khan, Sajid Khan Sadozai, Islam A. Khalil, Asem Anter, Marwa El Fouly, Ahmed H. Osman and Mohsin Kazi
Polymers 2022, 14(6), 1135; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14061135 - 11 Mar 2022
Cited by 17 | Viewed by 2697
Abstract
Antibiotics delivered through conventional dosage against ophthalmic infections show lower therapeutic efficacy due to their low residence time. Therefore, there is a great need to design and develop novel dosage forms that would increase the ocular residence time of antibiotics at the site [...] Read more.
Antibiotics delivered through conventional dosage against ophthalmic infections show lower therapeutic efficacy due to their low residence time. Therefore, there is a great need to design and develop novel dosage forms that would increase the ocular residence time of antibiotics at the site of infection. This study describes the development of nanoparticles laden in situ gelling solution, intended to sustain antibiotic release for improved therapeutic efficiency. Oxytetracycline-loaded gelatin-polyacrylic acid nanoparticles were prepared and incorporated in poloxamer-N407 solution. The rheological properties of the system were studied concerning time and temperature. Moreover, in vivo biocompatibility of the system was ascertained using the Draize test and histological studies. Finally, the optimized formulation was evaluated for in vitro antibacterial activity against one of the most common keratitis causing bacteria, Pseudomonas aeruginosa. Additionally, the in vivo efficacy was evaluated on the rabbit’s eye conjunctivitis model. The formulation showed a sustained effect against keratitis; furthermore, the antibacterial activity was comparable with the commercial product. Full article
(This article belongs to the Special Issue Polymer-Based Materials for Ophthalmic Applications)
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