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Polymers
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Advanced Polymers for Cancer Therapy and Bioimaging
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Advanced Polymers for Cancer Therapy and Bioimaging

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 7857

Special Issue Editor

Dr. Jung-Jae Lee

E-Mail Website
Guest Editor
Department of Chemistry, University of Colorado Denver, Campus Box 194, P.O. Box 173364, Denver, CO 80217, USA
Interests: theranostic imaging; biosensors; nanoprobes; optical imaging; fluorescence guided surgery; molecular recognition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advanced polymeric nanoparticles have served as an excellent platform for imaging probes and drug delivery to improve cancer detection, diagnosis, imaging, and therapy while reducing the toxicity of traditional cancer therapy. Importantly, a single nanoparticle can incorporate various probes, target ligands, and/or therapeutic drugs followed by bioconjugation on the surface or the encapsulation of molecules. Thus, rationally designed nanoparticles possess multimodality in imaging and elucidate the pharmacokinetics and pharmacodynamics of the cancer therapeutics with minimal side effects on adjacent tissues and organs. Therefore, recent advances in cancer therapy and bioimaging using advanced polymeric nanomaterials have laid the groundwork for vibrant new interdisciplinary research. We look forward to receiving contributions in these research areas that push the boundaries of this exciting new field.

Prof. Dr. Jung-Jae Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Molecular-targeted therapy for cancer
  • Sustained release drug delivery systems
  • Stimulus sensitive drug delivery systems
  • Multimodal nanoparticulate bioimaging
  • Molecular imaging (MRI, CT, optical imaging, etc.)
  • Enhanced permeability and retention effect of nanoparticles
  • Nanoparticle characterization
  • Cancer cell targeting and detection.

Published Papers (3 papers)

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Research

11 pages, 2401 KiB  
Article
Impact of Poly (Styrene–Acrylic Acid) Latex Nanoparticles on Colorectal and Cervical Cancer Cells
by Munther Alomari, Arwa Almahasheer, Balasamy Rabindran Jermy, Amal A. Al-Dossary, Hiba Bahmdan, Vijaya Ravinayagam, Deena Ababneh, Mohamad Tarhini and Abdelhamid Elaissari
Polymers 2021, 13(13), 2025; https://0-doi-org.brum.beds.ac.uk/10.3390/polym13132025 - 22 Jun 2021
Cited by 3 | Viewed by 2022
Abstract
Polymer nanoparticles are a promising approach for cancer treatment and detection, due to their biocompatibility, biodegradability, targeting capabilities, capacity for drug loading and long blood circulation time. This study aims to evaluate the impact of poly (styrene–acrylic acid) latex particles on colorectal and [...] Read more.
Polymer nanoparticles are a promising approach for cancer treatment and detection, due to their biocompatibility, biodegradability, targeting capabilities, capacity for drug loading and long blood circulation time. This study aims to evaluate the impact of poly (styrene–acrylic acid) latex particles on colorectal and cervical cancer cells for anti-tumor efficiency. Latex particles were synthesized by a surfactant-free radical emulsion polymerization process and the obtained polymer particles were characterized in terms of size, size distribution, morphology using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and electrokinetic property (i.e., zeta potential). Human colorectal and cervical cancer, and normal cell lines, were then treated with different concentrations of poly (styrene–acrylic acid) latex particles. The cell morphology changes were pointed out using an optical microscope and the nanoparticles’ (NPs) cell cytotoxicity was evaluated using MTT assay. The obtained results showed that poly (styrene–acrylic acid) latex particles are effective against colorectal and cervical cancer cells if treated with an appropriate particle concentration for 48 h. In addition, it showed that normal cells are the least affected by this treatment. This indicates that these NPs are safe as a drug delivery carrier when used at a low concentration. Full article
(This article belongs to the Special Issue Advanced Polymers for Cancer Therapy and Bioimaging)
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11 pages, 1478 KiB  
Article
Light-Responsive Polymeric Micellar Nanoparticles with Enhanced Formulation Stability
by Kyoung Nan Kim, Keun Sang Oh, Jiwook Shim, Isabel R. Schlaepfer, Sana D. Karam and Jung-Jae Lee
Polymers 2021, 13(3), 377; https://0-doi-org.brum.beds.ac.uk/10.3390/polym13030377 - 26 Jan 2021
Cited by 17 | Viewed by 2405
Abstract
Light-sensitive polymeric micelles have recently emerged as promising drug delivery systems for spatiotemporally controlled release of payload at target sites. Here, we developed diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles that showed a change in polarity of the micellar core from hydrophobic to hydrophilic under UV [...] Read more.
Light-sensitive polymeric micelles have recently emerged as promising drug delivery systems for spatiotemporally controlled release of payload at target sites. Here, we developed diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles that showed a change in polarity of the micellar core from hydrophobic to hydrophilic under UV light, releasing the encapsulated anti-cancer drug, doxetaxel (DTX). The micelles exhibited a low critical micelle concentration and high stability in the presence of bovine serum albumin (BSA) solution due to the hydrophobic and π–π stacking interactions in the micellar core. Cell studies showed enhanced cytotoxicity of DTX-loaded micellar nanoparticles upon irradiation. The enhanced stability would increase the circulation time of the micellar nanoparticles in blood, and enhance the therapeutic effectiveness for cancer therapy. Full article
(This article belongs to the Special Issue Advanced Polymers for Cancer Therapy and Bioimaging)
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17 pages, 3732 KiB  
Article
Synthesis Characterization of Platinum (IV) Complex Curcumin Backboned Polyprodrugs: In Vitro Drug Release Anticancer Activity
by Honglei Zhang, Yanjuan Wu, Xiao Xu, Chen Chen, Xiukun Xue, Ben Xu, Tianduo Li and Zhaowei Chen
Polymers 2021, 13(1), 67; https://0-doi-org.brum.beds.ac.uk/10.3390/polym13010067 - 26 Dec 2020
Cited by 13 | Viewed by 2753
Abstract
The conventional mono-chemotherapy still suffers from unsatisfied potency for cancer therapy due to tumor heterogeneity and the occurrence of drug resistance. Combination chemotherapy based on the nanosized drug delivery systems (nDDSs) has been developed as a promising platform to circumvent the limitations of [...] Read more.
The conventional mono-chemotherapy still suffers from unsatisfied potency for cancer therapy due to tumor heterogeneity and the occurrence of drug resistance. Combination chemotherapy based on the nanosized drug delivery systems (nDDSs) has been developed as a promising platform to circumvent the limitations of mono-chemotherapy. In this work, starting from cisplatin and curcumin (Cur), we prepared a dual drug backboned shattering polymeric nDDS for synergistic chemotherapy. By in situ polymerization of the Cur, platinum (IV) complex-based prodrug monomer (DHP), L-lysine diisocyanate (LDI), and then conjugation with a hydrophilic poly (ethylene glycol) monomethyl ether (mPEG) derivative, a backbone-type platinum (IV) and Cur linkage containing mPEG-poly(platinum-co-Cur)-mPEG (PCPt) copolymer was synthesized. Notably, the platinum (IV) (Pt (IV)) and Cur were incorporated into the hydrophobic segment of PCPt with the fixed drugs loading ratio and high drugs loading content. The batch-to-batch variability could be decreased. The resulting prodrug copolymer then self-assembled into nanoparticles (PCPt NPs) with an average diameter around 100 nm, to formulate a synergetic nDDS. Importantly, PCPt NPs could greatly improve the solubility and stability of Cur. In vitro drug release profiles have demonstrated that PCPt NPs were stable in PBS 7.4, rapid burst release was greatly decreased, and the Pt and Cur release could be largely enhanced under reductive conditions due to the complete dissociation of the hydrophobic main chain of PCPt. In vitro cell viability test indicated that PCPt NPs were efficient synergistic chemotherapy units. Moreover, PCPt NPs were synergistic for cisplatin-resistant cell lines A549/DDP cells, and they exhibited excellent reversal ability of tumor resistance to cisplatin. This work provides a promising strategy for the design and synthesis of nDDS for combination chemotherapy. Full article
(This article belongs to the Special Issue Advanced Polymers for Cancer Therapy and Bioimaging)
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