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Polymers
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Polymers for Cell Engineering
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Polymers for Cell Engineering

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (15 March 2021) | Viewed by 5561

Special Issue Editor

Dr. Nataraja Sekhar Yadavalli

E-Mail Website
Guest Editor
Nanostructured Materials Laboratory and Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA
Interests: stimuli-responsive materials; polymers; nanofabrication; sensors; nanofibers; bioconjugates; bioplastics; tissue engineering

Special Issue Information

Dear Colleagues,

Polymer-based materials play a significant role in the field of tissue engineering and regenerative medicine, with cancer and stem cell research having drawn much more attention in recent decades. Due to the good performance in biodegradability and biocompatibility, polymeric materials were used widely for the two- and three-dimensional cell culture. The 3D structure could be easily obtained during the fabrication of the polymeric scaffolds, and it provides a similar architectural framework of the native extracellular matrix. The research related to the 3D cell culture will provide many new visions for further studies in the field of tissue engineering and regeneration.

This Special Issue covers all the fields related to the applications of polymers in cell engineering, but special attention will be given to the following aspects: polymeric scaffolds with 3D structure; biodegradability, biocompatibility and antibacterial properties of polymeric materials; 3D cell culture; cell-interactive polymers for tissue engineering and regeneration; stem cell engineering; functional polymer surfaces for controlling cell behaviors; and smart polymers for cell therapy and precision medicine.

Authors are welcome to submit their latest research in the form of original full articles, communications, or reviews on this topic.

Dr. Nataraja Sekhar Yadavalli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymeric scaffolds
  • biodegradability, biocompatibility and antibacterial properties
  • 3D cell culture
  • cell-interactive polymers for tissue engineering and regeneration
  • stem cell engineering
  • functional polymer surfaces
  • cell therapy and precision medicine

Related Special Issue

Published Papers (2 papers)

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Research

15 pages, 41306 KiB  
Article
Characterization of Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells Response on Multilayer Braided Silk and Silk/PLCL Scaffolds for Ligament Tissue Engineering
by Xing Liu, Adrien Baldit, Emilie de Brosses, Frédéric Velard, Ghislaine Cauchois, Yun Chen, Xiong Wang, Natalia de Isla and Cédric Laurent
Polymers 2020, 12(9), 2163; https://0-doi-org.brum.beds.ac.uk/10.3390/polym12092163 - 22 Sep 2020
Cited by 8 | Viewed by 2860
Abstract
(1) Background: A suitable scaffold with adapted mechanical and biological properties for ligament tissue engineering is still missing. (2) Methods: Different scaffold configurations were characterized in terms of morphology and a mechanical response, and their interactions with two types of stem cells (Wharton’s [...] Read more.
(1) Background: A suitable scaffold with adapted mechanical and biological properties for ligament tissue engineering is still missing. (2) Methods: Different scaffold configurations were characterized in terms of morphology and a mechanical response, and their interactions with two types of stem cells (Wharton’s jelly mesenchymal stromal cells (WJ-MSCs) and bone marrow mesenchymal stromal cells (BM-MSCs)) were assessed. The scaffold configurations consisted of multilayer braids with various number of silk layers (n = 1, 2, 3), and a novel composite scaffold made of a layer of copoly(lactic acid-co-(e-caprolactone)) (PLCL) embedded between two layers of silk. (3) Results: The insertion of a PLCL layer resulted in a higher porosity and better mechanical behavior compared with pure silk scaffold. The metabolic activities of both WJ-MSCs and BM-MSCs increased from day 1 to day 7 except for the three-layer silk scaffold (S3), probably due to its lower porosity. Collagen I (Col I), collagen III (Col III) and tenascin-c (TNC) were expressed by both MSCs on all scaffolds, and expression of Col I was higher than Col III and TNC. (4) Conclusions: the silk/PLCL composite scaffolds constituted the most suitable tested configuration to support MSCs migration, proliferation and tissue synthesis towards ligament tissue engineering. Full article
(This article belongs to the Special Issue Polymers for Cell Engineering)
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11 pages, 8252 KiB  
Article
Functional Polylactide Blend Films for Controlling Mesenchymal Stem Cell Behaviour
by Yuliya Nashchekina, Pavel Nikonov, Alexey Nashchekin and Natalya Mikhailova
Polymers 2020, 12(9), 1969; https://0-doi-org.brum.beds.ac.uk/10.3390/polym12091969 - 30 Aug 2020
Cited by 6 | Viewed by 2204
Abstract
Polymer blending is a suitable physical modification method to create novel properties of different polymers. Blending polylactic acid (PLA) and polyethylene glycol (PEG) produces materials with a wide range of properties. This study was the first to investigate the effect of different isomeric [...] Read more.
Polymer blending is a suitable physical modification method to create novel properties of different polymers. Blending polylactic acid (PLA) and polyethylene glycol (PEG) produces materials with a wide range of properties. This study was the first to investigate the effect of different isomeric forms of PLA and PEG with terminal amino groups to obtain biocompatible films for human mesenchymal stem cell cultivation. It has been shown by scanning electron microscopy that the surface topology changes to the greatest extent when using films obtained on the basis of poly(d,l-lactide) and PEG with high molecular weights (15,000 g/mol). In order to obtain thin films and rapid evaporation of the solvent, PEG is mixed with PLA and does not form a separate phase and is not further washed out during the incubation in water. The presence of PEG with terminal hydroxyl and amino groups in blend films after incubation in water was proven using Fourier transform infrared (FTIR) spectroscopy. Results of fluorescence microscopy demonstrated that blend films formed on PLA and polyethylene glycol diamine (PEG-NH2) are more suitable for cell spreading and focal contact formation compared to cells cultured on the surface of pure PLA films or films made from PLA and PEG. Full article
(This article belongs to the Special Issue Polymers for Cell Engineering)
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