Current Trends and Advances in Stimuli-Responsive Polymers and Hydrogels

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Networks".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 2919

Special Issue Editors


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Guest Editor
School of Medicine, Royal College of Surgeons in Ireland (RCSI), Medical University of Bahrain, Busaiteen, Bahrain
Interests: stimuli-responsive polymers; microgels; hydrogels; nanoparticles; energy storage materials; nanomedicine; scattering methods
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Guest Editor
Department of Chemistry & Nanoscience Center, Aarhus University, Aarhus C, Denmark
Interests: Scattering methods; small angle x-ray scattering; microgels; proteins; membranes; nanomedicine

Special Issue Information

Dear Colleagues,

One of the basic processes of living organisms is response to stimuli. Using this fundamental, natural process as a basis, scientists have long been involved in the development of novel materials that respond to external stimuli. Stimuli-responsive polymers are polymers that respond to various external stimuli such as pH, temperature, ionic strength, surfactants, pressure, light, magnetic field, and enzymes. An important feature of these polymers is reversibility. These polymers have the ability to return to their initial state upon application of a counter-trigger. Given this important reversible stimuli-responsive property, these materials have found applications in targeted drug delivery systems, biosensing, tissue regeneration, wound healing, artificial organs, and more.

Progress in medicine today heavy relies on the development of new systems to detect and treat pathological events during the early stages with minimal side effects. In this respect, stimuli-responsive systems are of particular interest, as response to external stimuli represents an important property in medical applications. A large variety of stimuli-responsive polymers has been developed to serve diagnostic and therapeutic processes, and this field continues to grow. Understanding the structure–property relationships of new stimuli-responsive materials is highly essential for rational design with targeted applications in medicine.

For this Special Issue, “Current Trends and Advances in Stimuli-Responsive Polymers and Hydrogels”, we will consider manuscripts that deal with synthesis methodologies, structure–property relationships, and biomedical applications of stimuli-responsive polymers.

Dr. G Roshan Deen
Prof. Dr. Jan Skov Pedersen
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Stimuli-responsive polymers and hydrogels
  • Hybrid hydrogels
  • Advanced characterization
  • Self-assembly
  • Biomedical applications
  • Polymer materials
  • Physical characterization
  • Biomedical applications
  • Polymer engineering

Published Papers (1 paper)

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Research

14 pages, 9193 KiB  
Article
Development of Thermally Responsive PolyNIPAm Microcarrier for Application of Cell Culturing—Part I: A Feasibility Study
by Pui May Chou, Poi Sim Khiew, Paul D Brown and Binjie Hu
Polymers 2021, 13(16), 2629; https://0-doi-org.brum.beds.ac.uk/10.3390/polym13162629 - 07 Aug 2021
Cited by 3 | Viewed by 2284
Abstract
Poly(N-isopropylacrylamide) (polyNIPAm) microspheres were synthesized via the suspension polymerization technique. Thermal and redox initiators were compared for the polymerization, in order to study the effect of initiator type on the surface charge and particle size of polyNIPAm microspheres. The successful polymerization [...] Read more.
Poly(N-isopropylacrylamide) (polyNIPAm) microspheres were synthesized via the suspension polymerization technique. Thermal and redox initiators were compared for the polymerization, in order to study the effect of initiator type on the surface charge and particle size of polyNIPAm microspheres. The successful polymerization of NIPAm was confirmed by FTIR analysis. Microspheres of diameter >50 µm were synthesized when a pair of ammonium persulfate (APS) and N,N,N’,N’-tetramethylene-diamine (TEMED) redox initiators was used, whilst relatively small microspheres of ~1 µm diameter were produced using an Azobis-isobutyronitrile (AIBN) thermal initiator. Hence, suspension polymerization using a redox initiator pair was found to be more appropriate for the synthesis of polyNIPAm microspheres of a size suitable for human embryonic kidney (HEK) cell culturing. However, the zeta potential of polyNIPAm microspheres prepared using an APS/TEMED redox initiator was significantly more negative than AIBN thermal initiator prepared microspheres and acted to inhibit cell attachment. Conversely, strong cell attachment was observed in the case of polyNIPAm microspheres of diameter ~90 µm, prepared using an APS/TEMED redox initiator in the presence of a cetyl trimethyl ammonium bromide (CTAB) cationic surfactant; demonstrating that surface charge modified polyNIPAm microspheres have great potential for use in cell culturing. Full article
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