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Polymers
Special Issues
Functional Polymer Materials for Cell-Based Tissue Regeneration
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Functional Polymer Materials for Cell-Based Tissue Regeneration

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 4679

Special Issue Editor

Prof. Dr. Ying-Chieh Chen

E-Mail Website
Guest Editor
Department of Materials Science and Engineering, National Tsing-Hua University, Hsinchu 30013, Taiwan
Interests: polymers; vascular tissue engineering; biomaterial-mediated tissue regeneration; stem cell and regenerative medicine; implantable biosensors

Special Issue Information

Dear Colleagues,

Cell-based therapy is a promising approach for the treatment of various diseases and injuries. This Special Issue aims at presenting the main advances in the field of biomimetic polymers for cell-based therapies in tissue engineering and regeneration. Multiple cell types can be utilized in such therapies, including stem, progenitor or primary cells. Biomimetic polymers have been designed as the cell delivery vesicle to elicit specific cellular functions, to direct cell–cell interactions, to improve their biological functions, and accelerate tissue repair at the designated site. Additionally, the functions of delivered living cells can be regulated by stimuli-responsive multifunctional polymers which respond to changes in the surrounding microenvironment to speed up wound healing. This Special Issue covers but is not limited to such topics as smart biomimetic polymers, multifunctional polymers, bioactive polymers, biodegradable polymers, microfabrication of polymers, regenerative medicine, hard and soft tissue regeneration, in vitro studies, in vivo investigations, preclinical studies, and clinical applications.

Prof. Dr. Ying-Chieh Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional polymers
  • biomimetic polymers
  • bioactive polymers
  • biodegradable polymers
  • cell-based therapy
  • tissue engineering and regeneration
  • stimuli-responsive
  • regenerative medicine

Published Papers (1 paper)

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Research

20 pages, 18755 KiB  
Article
Biofunctional Hyaluronic Acid/κ-Carrageenan Injectable Hydrogels for Improved Drug Delivery and Wound Healing
by Uzma Ijaz, Muhammad Sohail, Muhammad Usman Minhas, Shahzeb Khan, Zahid Hussain, Mohsin Kazi, Syed Ahmed Shah, Arshad Mahmood and Mohammed Maniruzzaman
Polymers 2022, 14(3), 376; https://0-doi-org.brum.beds.ac.uk/10.3390/polym14030376 - 19 Jan 2022
Cited by 16 | Viewed by 4098
Abstract
The in situ injectable hydrogel system offers a widespread range of biomedical applications in prompt chronic wound treatment and management, as it provides self-healing, maintains a moist wound microenvironment, and offers good antibacterial properties. This study aimed to develop and evaluate biopolymer-based thermoreversible [...] Read more.
The in situ injectable hydrogel system offers a widespread range of biomedical applications in prompt chronic wound treatment and management, as it provides self-healing, maintains a moist wound microenvironment, and offers good antibacterial properties. This study aimed to develop and evaluate biopolymer-based thermoreversible injectable hydrogels for effective wound-healing applications and the controlled drug delivery of meropenem. The injectable hydrogel was developed using the solvent casting method and evaluated for structural changes using proton nuclear magnetic resonance, Fourier transforms infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. The results indicated the self-assembly of hyaluronic acid and kappa-carrageenan and the thermal stability of the fabricated injectable hydrogel with tunable gelation properties. The viscosity assessment indicated the in-situ gelling ability and injectability of the hydrogels at various temperatures. The fabricated hydrogel was loaded with meropenem, and the drug release from the hydrogel in phosphate buffer saline (PBS) with a pH of 7.4 was 96.12%, and the simulated wound fluid with a pH of 6.8 was observed to be at 94.73% at 24 h, which corresponds to the sustained delivery of meropenem. Antibacterial studies on P. aeruginosa, S. aureus, and E. coli with meropenem-laden hydrogel showed higher zones of inhibition. The in vivo studies in Sprague Dawley (SD) rats presented accelerated healing with the drug-loaded injectable hydrogel, while 90% wound closure with the unloaded injectable hydrogel, 70% in the positive control group (SC drug), and 60% in the negative control group was observed (normal saline) after fourteen days. In vivo wound closure analysis confirmed that the developed polymeric hydrogel has synergistic wound-healing potential. Full article
(This article belongs to the Special Issue Functional Polymer Materials for Cell-Based Tissue Regeneration)
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