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Glycopolymers and Polysaccharide-Based Copolymers

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A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 10436

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Special Issue Editors

Prof. Dr. Jean-Luc Six

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Guest Editor

LCPM, Université de Lorraine, CNRS, F-54000 Nancy, France
Interests: controlled polymerizations; glycopolymers and polysaccharide-based copolymers; polymeric biomaterials
Special Issues, Collections and Topics in MDPI journals

Dr. Khalid Ferji

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Guest Editor

LCPM, Université de Lorraine, CNRS, F-54000 Nancy, France
Interests: copolymer self-assembly; photo-polymerization; polymerization induced-self-assembly; nanotechnology; drug delivery
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Yoshiko Miura

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Guest Editor

Department of Chemical Engineering, Graduate School of Engineering, Kyushu University, Fukuoka 819-0395, Japan
Interests: glycopolymer; molecular recognition; bio-interface; porous materials

Special Issue Information

Dear Colleagues,

Narrowly defined, glycopolymers are synthetic polymers modified with saccharidic moieties exhibiting specific biological functionality. Such glycopolymers can be obtained either by chemical modification of the synthetic polymers with adequate carbohydrates or by controlled polymerization of glycomonomers (monomers containing a (oligo)saccharidic part).

More broadly, glycopolymers can be defined as copolymers associating natural polysaccharides and synthetic polymers. In this case, they can be produced by coupling controlled polymer chains onto polysaccharide ones (grafting onto strategy) or by using modified polysaccharides as macroinitiators within a controlled polymerization (grafting from strategy). In addition, associating the hydrophilic behavior of polysaccharide to the hydrophobic one of synthetic polymers chains allows the elaboration of amphiphilic glycopolymers, which can stabilize an interface or self-assemble into nanostructures, for instance. Such “polysaccharide-based copolymers” can exhibit particular bio-functionality if bioactive polysaccharide and biodegradable or biocompatible synthetic parts are chosen.

Regardless of the definition of glycopolymers, such copolymers are currently attracting great interest from the scientific community as they can offer a suitable alternative to existing nondegradable oil-sourced polymeric materials; especially in biomedical, pharmaceutical, food and environmental fields.

This Special Issue will provide an overview of recent advances in glycopolymers and polysaccharide-based copolymers controlled syntheses, characterizations, and formulations, and the associated applications in biomedical, pharmaceutical, food, and environmental domains. As Guest Editors, we cordially invite contributions in the form of original research articles or reviews on this subject.

Prof. Jean-Luc Six
Dr. Khalid Ferji
Prof. Yoshiko Miura
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Sensitive glycopolymers or polysaccharide-based copolymers
Controlled polymerizations
Self-assembly and formulation
Biological interaction
Drug delivery systems
Biobased surfactants
Interface modifiers

Published Papers (4 papers)

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Research

14 pages, 1418 KiB

Open AccessArticle

The Influence of Maltodextrin on the Thermal Transitions and State Diagrams of Fruit Juice Model Systems

by Pedro García-Coronado, Alma Flores-Ramírez, Alicia Grajales-Lagunes, Cesar Godínez-Hernández, Miguel Abud-Archila, Raúl González-García and Miguel A. Ruiz-Cabrera

Polymers 2020, 12(9), 2077; https://0-doi-org.brum.beds.ac.uk/10.3390/polym12092077 - 12 Sep 2020

Cited by 4 | Viewed by 2882

Abstract

The state diagram, which is defined as a stability map of different states and phases of a food as a function of the solid content and temperature, is regarded as fundamental approach in the design and optimization of processes or storage procedures of food in the low-, intermediate-, and high-moisture domains. Therefore, in this study, the effects of maltodextrin addition on the freezing points (

T_{m}^{'}

T_{m}

) and glass transition temperatures (

T_{g}^{'}

T_{g}

) required for the construction of state diagrams of fruit juice model systems by using differential scanning calorimetry methods was investigated. A D-optimal experimental design was used to prepare a total of 25 anhydrous model food systems at various dry mass fractions of fructose, glucose, sucrose, pectin, citric acid, and maltodextrin, in which this last component varied between 0 and 0.8. It was found that maltodextrin mass fractions higher than 0.4 are required to induce significant increases of

T_{g}^{'}

T_{m}^{'}

T_{g}

, and

T_{m}

curves. From this perspective, maltodextrin is a good alternative as a cryoprotectant and as a carrier agent in the food industry. Furthermore, solute-composition-based mathematical models were developed to evaluate the influence of the chemical composition on the thermal transitions and to predict the state diagrams of fruit juices at different maltodextrin mass fractions. Full article

(This article belongs to the Special Issue Glycopolymers and Polysaccharide-Based Copolymers)

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Figure 1

9 pages, 1653 KiB

Open AccessArticle

Facile One-Pot Synthesis of Hyperbranched Glycopolymers in Aqueous Solution via a Hydroxy/Cu(III) Redox Process

by Feng Liu, Yuangong Zhang, Xiaohui Hao, Qian Zhou, Ying Zheng, Libin Bai and Hailei Zhang

Polymers 2020, 12(9), 2065; https://0-doi-org.brum.beds.ac.uk/10.3390/polym12092065 - 11 Sep 2020

Cited by 1 | Viewed by 1845

Abstract

In this study, a self-condensing vinyl copolymerization/redox (SCVP/Redox) system was constructed to prepare hyperbranched poly(methyl-6-O-methacryloyl-α-D-glucoside) by using Cu(III) as the initiator in aqueous solution, in which the –OH group in C-2, C-3 and C-4 position on pyranose rings could be initiated by Cu(III). The branched and linear units were clearly distinguished by nuclear magnetic resonance (¹H NMR) to estimate the degree of branching (DB). When the ratio of Cu(III) to monomer fixed at 0.5:1, the DB value reached 0.32, which was higher than the product initiated by Ce(IV). Moreover, the inhibition activity of the products on amyloid fibrillation was investigated by using the hen egg-white lysozyme (HEWL) as a model based on the difference of the initiation sites. The results showed that the –OH groups in C-4 position might play an important role in this process. Full article

(This article belongs to the Special Issue Glycopolymers and Polysaccharide-Based Copolymers)

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Graphical abstract

10 pages, 1944 KiB

Open AccessArticle

Synthesis and Aggregation Behavior of Temperature- and pH-Responsive Glycopolymers as Sugar-Displaying Conjugates

by Sotaro Tsuji, Tomohiro Aoki, Shunsuke Ushio and Tomonari Tanaka

Polymers 2020, 12(4), 956; https://0-doi-org.brum.beds.ac.uk/10.3390/polym12040956 - 20 Apr 2020

Cited by 6 | Viewed by 2326

Abstract

Stimuli-responsive polymers have attracted significant interest in the fields of advanced materials and biomaterials. Herein, temperature- and pH-responsive glycopolymers, which are composed of N-isopropylacrylamide, methacrylic acid, and an acrylamide derivative bearing a lactose moiety, were synthesized via radical copolymerization. The series of resulting glycopolymers had different degrees of substitution of the lactose moieties, were responsive to temperatures between 26.6 °C and 47.6 °C, and formed aggregates above the lower critical solution temperature limit in mild acidic aqueous media (pH 4–6). The temperature-responsive behavior was dependent on the prevailing pH conditions, as no aggregation was observed in neutral and basic aqueous media (pH > 7). The aggregates had saccharide moieties on the surface in aqueous media. The number of saccharide moieties on the surface depended on the saccharide-containing unit ratio in the glycopolymer. The ratio was determined via enzymatic hydrolysis of the lactose moieties using β-galactosidase and the subsequent detection of the released galactose. Full article

(This article belongs to the Special Issue Glycopolymers and Polysaccharide-Based Copolymers)

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Graphical abstract

13 pages, 2159 KiB

Open AccessArticle

Biodegradation Pattern of Glycopolymer Based on D-Mannose Oligomer and Hydroxypropyl Acrylate

by Ana-Maria Pană, Valentin Ordodi, Gerlinde Rusu, Vasile Gherman, Geza Bandur, Lucian-Mircea Rusnac and Gabriela-Alina Dumitrel

Polymers 2020, 12(3), 704; https://0-doi-org.brum.beds.ac.uk/10.3390/polym12030704 - 22 Mar 2020

Cited by 4 | Viewed by 2828

Abstract

Glycopolymers are polymers with sugar moieties which display biodegradable and/or biocompatible character. They have emerged as an environmentally-friendly solution to classical synthetic polymers and have attracted significant research interest in the past years. Herein, we present the synthesis of a D-mannose based glycopolymer with biodegradable features. The glycopolymer was synthesized by radical copolymerization between a D-mannose oligomer bearing polymerizable double bonds and 2-hydroxypropyl acrylate, in a weight ratio of 1:2. The copolymerization kinetics was investigated by differential scanning calorimetry (DSC) and the activation energy of the process was comparatively assessed by Kissinger–Akahira–Sunose and Flynn–Wall–Ozawa methods. The obtained glycopolymer displayed good thermal behavior, fact proven by thermogravimetrical (TG) analysis and it was submitted to biodegradation inside a bioreactor fed with water from the Bega River as the source of microbial inoculum. The glycopolymer sample degraded by approximately 60% in just 23 days. The biodegradation pattern of the glycopolymer was successfully fitted against a modified sigmoidal exponential function. The kinetic model coefficients and its accuracy were calculated using Matlab and the correlation coefficient is more than promising. The changes inside glycopolymer structure after biodegradation were studied using TG and FTIR analyses, which revealed that the sugar moiety is firstly attacked by the microbial consortia as nutrient source for proliferation. Full article

(This article belongs to the Special Issue Glycopolymers and Polysaccharide-Based Copolymers)

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