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Polymers
Special Issues
Tailored Polymers for Biomedical Applications
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Tailored Polymers for Biomedical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (1 June 2022) | Viewed by 4513

Special Issue Editor

Dr. Enrique Martinez Campos

E-Mail Website
Guest Editor
Polymer Functionalization Group, Institute of Polymer Science and Technology, ICTP-CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain
Interests: biomaterials; polymer networks; surface activation; tissue engineering; cytocompatibility; cell sheet engineering; antimicrobial and antiviral activity

Special Issue Information

Dear Colleagues,

Polymers have found preferential use in biomedical applications related to implantology, drug delivery, biosensing, gene therapy or tissue engineering.

Due to their versatility, polymeric materials can be designed to optimize their action in contact with living tissues. In the field of implantology, degradability, porosity, topography or surface activation determine several features for the permanent or temporary use of the implant. In the same way, the interaction with cellular or molecular agents of the microenvironment influences early biological response, cell survival and future implant integration. In addition, the antibacterial or antibiofouling properties reduce the appearance of associated infections and increase the success of the surgery.

On the other hand, biosensing devices focus their developments in specificity and performance, especially in diagnosis and disease monitoring. Likewise, other strategies related to drug release and particularly antimicrobial delivery have starred custom-made therapeutical approaches. In addition, the global situation caused by the SARS-COV-2 pandemic has stimulated the emergence of new strategies designed to detect or reduce viral viability and/or infectivity. However, it is necessary to point out that the clinical needs regarding other diseases (metabolic, cancer) or injuries (trauma, burns) persist.

This Special Issue on "Tailored Polymers for Biomedical Applications" will focus on the new insights on polymeric materials designs and implementations, including biological evaluation, antimicrobial/antiviral strategies and other preclinical approaches. While covering a broad range of fundamental, experimental, and industrial topics, we warmly invite academics and scientists to contribute with original research papers, short communications, and review articles.

Dr. Enrique Martinez Campos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biocompatibility
  • implant
  • antibacterial
  • antiviral
  • biosensor
  • drug delivery
  • tissue engineering

Published Papers (2 papers)

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Research

15 pages, 4092 KiB  
Article
Ultrastructural and Physicochemical Characterization of a Non-Crosslinked Type 1 Bovine Derived Collagen Membrane
by Igor da Silva Brum, Carlos Nelson Elias, Ana Lucia Rosa Nascimento, Cherley Borba Vieira de Andrade, Ronaldo Sergio de Biasi and Jorge José de Carvalho
Polymers 2021, 13(23), 4135; https://0-doi-org.brum.beds.ac.uk/10.3390/polym13234135 - 26 Nov 2021
Cited by 3 | Viewed by 2087
Abstract
In this work, in vitro testing was used to study the properties of non-crosslinked type 1 bovine derived collagen membranes used in bone regeneration surgery. Collagen membranes were prepared, their surface roughness was quantified by interferometry, their morphology was observed by scanning electron [...] Read more.
In this work, in vitro testing was used to study the properties of non-crosslinked type 1 bovine derived collagen membranes used in bone regeneration surgery. Collagen membranes were prepared, their surface roughness was quantified by interferometry, their morphology was observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), their wettability was measured by the contact angle technique, their mechanical properties were investigated by tensile testing, their phase transformation temperatures were measured by Differential Scanning Calorimetry (DSC), and their biocompatibility was evaluated by immunological testing. The calorimetry tests showed that the membrane is formed only by type 1 collagen. The SEM observations showed that the morphology consists of layers of highly organized collagen fibers and patterns of striated fibrils typical of type 1 collagen. The small contact angle showed that the membrane is hydrophilic, with the possibility of rapid absorption of body fluids. The tensile tests showed that the membrane has enough elasticity, ductility, and mechanical strength for use in tissue regeneration. With the immunostaining technique, it was possible to confirm the membrane biocompatibility. Full article
(This article belongs to the Special Issue Tailored Polymers for Biomedical Applications)
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16 pages, 2861 KiB  
Article
Fabrication and Characterization of Polymeric Pharmaceutical Emulgel Co-Loaded with Eugenol and Linalool for the Treatment of Trichophyton rubrum Infections
by Muhammad Abdullah Akram, Barkat Ali Khan, Muhammad Khalid Khan, Ali Alqahtani, Sultan M. Alshahrani and Khaled M. Hosny
Polymers 2021, 13(22), 3904; https://0-doi-org.brum.beds.ac.uk/10.3390/polym13223904 - 11 Nov 2021
Cited by 7 | Viewed by 1981
Abstract
Trichophyton rubrum (T. rubrum) is the main cause of chronic dermatophytosis which is highly prevalent worldwide. This study was aimed to fabricate and characterize polymeric emulgel of eugenol and linalool for the treatment of T. rubrum infections. Using the slow emulsification [...] Read more.
Trichophyton rubrum (T. rubrum) is the main cause of chronic dermatophytosis which is highly prevalent worldwide. This study was aimed to fabricate and characterize polymeric emulgel of eugenol and linalool for the treatment of T. rubrum infections. Using the slow emulsification method, the emulgel was prepared and characterized for thermodynamic stability, pH analysis, viscosity, spreadability, swelling behavior, %drug content, surface morphology, globules size, polydispersity index, surface charge (mV), thermal behavior, in vitro drug release and XRD studies. Biological activities of emulgel were conducted against T. rubrum in vitro and in vivo. Results indicated that emulgel formulations were thermodynamically stable. The pH of the formulations was within an acceptable range for skin. The viscosity and spreadability were optimum for the better patient compliance. The swelling behavior was 111.10 ± 1.25% after 90 min. The drug content was within the official pharmacopeia limit i.e., 100 ± 10%. The surface morphology revealed by scanning electron microscopy showed a spherical-shaped structure with characteristic larger cracks and wrinkles. The droplet size, PDI, and surface charge of the optimized emulgel were 888.45 ± 8.78 nm, 0.44 and −20.30 mV, respectively. The emulgel released 84.32% of eugenol and 76.93% of linalool after 12 h. There was complete disappearance of the diffraction peaks corresponding to the drugs after XRD analysis. In rabbits, the infection was safely and completely recovered after 12 days and the emulgel produced significant effects (p < 0.05) similar to the standard product Clotrim®. It is concluded that the eugenol–linalool emulgel best described all its physical properties and can be applied topically for the treatment of T. rubrum infections. Full article
(This article belongs to the Special Issue Tailored Polymers for Biomedical Applications)
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