Processes

Uncertainty and variability are inherent to pile design and consequently, there have been considerable researches in quantifying the reliability or probability of failure of structures. This paper aims at examining and comparing the applicability and adaptability of Minimax Probability Machine Regression (MPMR), Emotional Neural Network (ENN), Group Method of Data Handling (GMDH), and Adaptive Neuro-Fuzzy Inference System (ANFIS) in the reliability analysis of pile embedded in cohesionless soil and proposes an AI-based prediction method for bearing capacity of pile foundation. To ascertain the homogeneity and distribution of the datasets, Mann–Whitney U (M–W) and Anderson–Darling (AD) tests are carried out, respectively. The performance of the developed soft computing models is ascertained using various statistical parameters. A comparative study is implemented among reliability indices of the proposed models by employing First Order Second Moment Method (FOSM). The results of FOSM showed that the ANFIS approach outperformed other models for reliability analysis of bearing capacity of pile and ENN is the worst performing model. The value of R² for all the developed models is close to 1. The best RMSE value is achieved for the training phase of the ANFIS model (0 in training and 2.13 in testing) and the poorest for the ENN (2.03 in training and 31.24 in testing) model. Based on the experimental results of reliability indices, the developed ANFIS model is found to be very close to that computed from the original data. Full article

Although many benefits drawn from beer consumption are claimed, the epidemiological records are contradictory with respect to cancer prevention. The purpose of this study was to investigate the possible health-related activities involving genome safety and the ageing processes of two types of lyophilised ale beers (blond and stout), as well as two of their bioactive compounds (tyrosol and iso-alpha humulone). A multipurpose trial set of in vivo toxicity, antitoxicity, mutagenicity, antimutagenicity, lifespan and healthspan assays using Drosophila melanogaster were used. In parallel, several in vitro assays were designed using the cancer cell line HL-60 in order to establish the possible chemopreventive activity of the selected substances, where epigenetic modulation of DNA methylation changes, clastogenic activity and tumour cell inhibition growth were evaluated. The safety of the four substances was confirmed: lyophilised blond ale beer (LBAB), lyophilised stout ale beer (LSAB), tyrosol and iso-alpha humulone were neither toxic nor genotoxic. Moreover, all substances, except tyrosol, revealed the ability to protect individual genomes against oxidative radicals and to exert antimutagenic activity against the genotoxin hydrogen peroxide. With respect to the degenerative process indicators of lifespan and healthspan, tyrosol was the only compound that did not exert any influence on the life extension of Drosophila; LBAB induced a significant lifespan extension in D. melanogaster; LSAB and its distinctive compound iso-alpha humulone induced a reduction in longevity. The in vitro assays showed the cytotoxic activity of LBAB, LSAB and tyrosol against HL-60 cells. Moreover, proapoptotic DNA fragmentation or DNA strand breakage was observed for both types of beers and iso-alpha humulone at different concentrations. Furthermore, the lyophilised ale beers and tyrosol exhibited an increasing genome-wide methylation status, while iso-alpha humulone exhibited a demethylation status in repetitive cancer cell sequences. Although the biological activities assigned to beer consumption cannot be linked to any specific molecule/element due to the complexity of the phenolic profile, as well as the multifactor brewing process, the results obtained let us propose lyophilised ale beers as safe potential nutraceutical beverages when consumed in moderate amounts. The prevention of toxicity and genetic oxidative damage, as well as the induction of tumor cell death and modulation of the methylation status, are the key activities of beer that were shown in the present research. Full article

The mechanical response and deformation mechanisms of TB17 titanium alloy were studied at room temperature by the split-Hopkinson pressure bar test. The ultimate compression strength increases from 1050 MPa to 1400 MPa, as the strain rate increases from 2000 s⁻¹ to 2800 s⁻¹. The adiabatic shear failure occurred at strain rate 2800 s⁻¹. When the strain rate was 2000 s⁻¹, only {10 9 3}<331>_β type II high index deformation twins, a small number of α” martensite, and interfacial ω phase were detected. When the strain rate was 2400 s⁻¹ and above, multiple deformation mechanisms, including the primary {10 9 3}<331>_β type II high index deformation twins, secondary {332}<113>_β deformation twins, and α” martensite were identified. The deformation mechanism changes from primary deformation twins and α” martensite to multiple deformation mechanisms (primary and secondary deformation structure) with the increase of strain rates. Full article

In this study, we examined the effect of ethanolic extract of Salicornia herbacea (ESH), isorhamnetin 3-O-glucoside (I3G), quercetin 3-O-glucoside (Q3G), quercetin, and isorhamnetin on α-glucosidase activity and glucose-stimulated insulin secretion (GSIS) in insulin-secreting rat insulinoma (INS-1) cells. A portion of the ethyl acetate fraction of ESH was chromatographed on a silica gel by a gradient elution with chloroform and methanol to provide Q3G and I3G. ESH, Q3G, and quercetin inhibited α-glucosidase activity, and quercetin (IC₅₀ value was 29.47 ± 3.36 μM) inhibited the activity more effectively than Q3G. We further demonstrated that ESH, Q3G, quercetin, I3G, and isorhamnetin promote GSIS in INS-1 pancreatic β-cells without inducing cytotoxicity. Among them, I3G was the most effective in enhancing GSIS. I3G enhanced the phosphorylation of total extracellular signal-regulated kinase (ERK), insulin receptor substrate-2 (IRS-2), phosphatidylinositol 3-kinase (PI3K), Akt, and activated pancreatic and duodenal homeobox-1 (PDX-1), which are associated with insulin secretion and β-cell function. As components of ESH, Q3G has the potential to regulate blood glucose by inhibiting α-glucosidase activity, and I3G enhances the insulin secretion, but its bioavailability should be considered in determining biological importance. Full article

The development of efficient methods for process performance verification has drawn a lot of attention in the research community. Viability theory is a mathematical tool to identify the trajectories of a dynamical system which remains in a constraint set. In this paper, viability theory is investigated for this purpose in the case of nonlinear processes that can be represented in Linear Parameter Varying (LPV) form. In particular, verification algorithms based on the use of invariance and viability kernels and capture basin are proposed. The difficulty with the application of this theory is the computation of these sets. A Lagrangian method has been used to approximate these sets. Because of simplicity and efficient computations, zonotopes are adopted for set representation. Two new sets called Safe Work Area (SWA) and Required Performance (RP) are defined and an algorithm is proposed to use these concepts for the verification purpose. Finally, two application examples based on well-known case studies, a two-tank system and pH neutralization plant, are provided to show the effectiveness of the proposed method. Full article

Cubing machines in food processing have evolved over the years, which have made products like Star^®, Knorr^®, and Chicken^® bouillon cubes become commercially available today, even in many parts of Africa. On the other hand, the fermented mesquite seed “okpeye” food condiment, traditionally produced by well-trained artisans and widely utilised in Nigeria, requires further product development in order to compete with bouillon cubes. Quality comparisons between the cubed “okpeye” condiment and commercially available bouillon cube products have not yet been reported. Therefore, cubing fabrication/costing and machine performance on African fermented “okpeye” condiment quality attributes, compared with commercial bouillon types, were done. The processing of mesquite seeds into the “okpeye” condiment resembled those of artisans. Bouillon cube products involved the Star^®, Knorr^®, and Chicken^® types. Quality attributes involved proximate, micronutrient, phytochemical, and microbial aspects. Results showed that the throughput capacity of a cubing machine increased with an efficiency of 48 condiment cubes/min, forming properly without separation. Across all studied samples, the protein, ash, moisture, crude fat, crude fibre, and carbohydrate contents were in the range of 1.45–42.50%, 5.29–6.75%, 8.50–12.29%, 2.56–18.54%, 2.45–3.19%, and 18.16–25.56%, respectively. The protein, fat, moisture, calcium, iron, magnesium, and manganese contents of “okpeye” condiment were significantly higher (p < 0.05) than those of bouillon cubes. Fair amounts of vitamins B1, B2, B3, and E were found, with the okpeye condiment higher in vitamin E. Besides the flavonoids (0.12–0.18%), alkaloids (0.08–0.15%), saponins (0.19–0.55%), and tannins (0.69–0.93%) present, the microbial loads were similar (p > 0.05) across all samples. Indeed, the okpeye condiment can be cubed, and by quality attribute, it competes favourably, and very promising substitute to commercial bouillon cubes. Full article

Ionic liquids can typically be synthesized via protonation, alkylation, metathesis, or neutralization reactions. The many types of ionic liquids have increased their attractiveness to researchers for employment in various areas, including in polymer composites. Recently, ionic liquids have been employed to modify nanofillers for the fabrication of polymer nanocomposites with improved physicochemical properties. In this succinct review, four types of imidazolium-based ionic liquids that are employed as modifiers—specifically alkylimidazolium halide, alkylimidazolium hexafluorophosphate, alkylimidazolium tetrafluoroborate, and alkylimidazolium bistriflimide—are reviewed. Additionally, three types of ionic liquid-modified nanofiller/polymer nanocomposites—namely ionic liquid-nanofiller/thermoplastic nanocomposites, ionic liquid-nanofiller/elastomer nanocomposites, and ionic liquid-nanofiller/thermoset nanocomposites—are described as well. The effect of imidazolium-based ionic liquids on the thermo-mechanico-chemical properties of the polymer nanocomposites is also succinctly reviewed. This review can serve as an initial guide for polymer composite researchers in modifying nanofillers by means of ionic liquids for improving the performance of polymer nanocomposites. Full article

Propylene glycol, also known as 1,2 propanediol, is one of the most important chemicals in the industry. It is a water-soluble liquid, considered by the U.S. Food and Drug Administration as safe to manufacture consumer products, including foodstuffs, medicines, and cosmetics. This chemical has essential properties, such as solvent, moisturizer, or antifreeze, in addition to a low level of toxicity. This paper aims to present the selection, simulation, and dimensioning of a trickle bed reactor at a laboratory scale. The sizing was validated with other authors. Two predictive models have been considered for reactor modeling, intrinsic kinetics and coupled intrinsic kinetics, along with mass transfer equations and the wetting of the catalyst particles. The model was implemented using Aspen Custom Modeler^® (20 Crosby Dr. Bedford, MA 01730, EE. UU.) to study the reactor behavior in terms of conversion. The results show the profiles of different variables throughout the reactor and present higher glycerol conversion when mass transfer is added to the model. Full article

During the transportation and packaging of low density polyethylene (LDPE) granular materials, fine dusts such as floccules, powder and fiber will be produced, which pollute the environment, affect product quality and generate fire hazards. In this work, the separation performance of fine dust and optimal operating conditions of an improved elutriator were investigated experimentally. Experiments were carried out to investigate the effects of air speed, feeding speed, and grid layout on the removal efficiency of fine particles. Experimental data showed that the separation efficiency of the novel elutriator ranged from 96% to 98.50%, which was more stable and an average of 51.44% higher than that of the original elutriator. By setting internals and improving the structure, the gas flow field in the equipment was regulated, the particle dispersion was intensified, and the static electricity was eliminated, which significantly improved the separation efficiency of fine dust. Full article

A symmetrical NACA 0018 airfoil is often used in such applications as small-to-medium scale vertical-axis wind turbines and aerial vehicles. A review of the literature indicates a large gap in experimental studies of this airfoil at low and moderate Reynolds numbers in the previous century. This gap has limited the potential development of classical turbulence models, which in this range of Reynolds numbers predict the lift coefficients with insufficiently accurate results in comparison to contemporary experimental studies. Therefore, this paper validates the aerodynamic performance of the NACA 0018 airfoil and the characteristics of the laminar separation bubble formed on its suction side using the standard uncalibrated four-equation Transition SST turbulence model and the unsteady Reynolds-averaged Navier-Stokes (URANS) equations. A numerical study was conducted for the chord Reynolds number of 160,000, angles of attack between 0 and 11 degrees, as well as for the free-stream turbulence intensity of 0.05%. The calculated lift and drag coefficients, aerodynamic derivatives, as well as the location and length of the laminar bubble quite well agree with the results of experimental measurements taken from the literature for validation. A sensitivity study of the numerical model was performed in this paper to examine the effects of the time-step size, geometrical parameters and mesh distribution around the airfoil on the simulation results. The airfoil data sets obtained in this work using the Transition SST and the k-ω SST turbulence models were used in the improved double multiple streamtube (IDMS) to calculate aerodynamic blade loads of a vertical-axis wind turbine. The characteristics of the normal component of the aerodynamic blade load obtained by the Transition SST approach are much better suited to the experimental data compared to the k-ω SST turbulence model. Full article

The application of white box models in digital twins is often hindered by missing knowledge, uncertain information and computational difficulties. Our aim was to overview the difficulties and challenges regarding the modelling aspects of digital twin applications and to explore the fields where surrogate models can be utilised advantageously. In this sense, the paper discusses what types of surrogate models are suitable for different practical problems as well as introduces the appropriate techniques for building and using these models. A number of examples of digital twin applications from both continuous processes and discrete manufacturing are presented to underline the potentials of utilising surrogate models. The surrogate models and model-building methods are categorised according to the area of applications. The importance of keeping these models up to date through their whole model life cycle is also highlighted. An industrial case study is also presented to demonstrate the applicability of the concept. Full article

Optimally designed functional foods are considered the most important part of a balanced and healthy diet. Goat meat nuggets, an otherwise healthy option, are packed with undesirable saturated and unsaturated fats. The present work suggests an optimal functional formulation to reduce the surplus fat content of goat meat nuggets by adding two optimally calculated functional ingredients, namely, fenugreek leaves (FL) and psyllium husk (PH). Response surface optimization was performed to determine the optimal content of the functional ingredients (FL and PH), resulting in minimum fat content without affecting the overall acceptability (OA) and other properties representing the taste and texture (e.g., ash content, pH, crude fiber content, and moisture content) of the nuggets. Functional additives at optimum levels successfully reduced the fat content of the weight-conserved nuggets by almost 39% compared with the control nuggets. Minimal and acceptable effects were observed regarding OA and other properties representative of the taste and texture of the nuggets. An optimally designed, fat-attenuated goat meat nugget formulation is therefore prescribed, which complies with the nutritional standards of a balanced diet. Full article

Muscular tissue regeneration may be enhanced in vitro by means of mechanical stimulation, inducing cellular alignment and the growth of functional fibers. In this work, a novel bioreactor is designed for the radial stimulation of porcine-derived diaphragmatic scaffolds aiming at the development of clinically relevant tissue patches. A Finite Element (FE) model of the bioreactor membrane is developed, considering two different methods for gripping muscular tissue patch during the stimulation, i.e., suturing and clamping with pliers. Tensile tests are carried out on fresh and decellularized samples of porcine diaphragmatic tissue, and a fiber-reinforced hyperelastic constitutive model is assumed to describe the mechanical behavior of tissue patches. Numerical analyses are carried out by applying pressure to the bioreactor membrane and evaluating tissue strain during the stimulation phase. The bioreactor designed in this work allows one to mechanically stimulate tissue patches in a radial direction by uniformly applying up to 30% strain. This can be achieved by adopting pliers for tissue clamping. Contrarily, the use of sutures is not advisable, since high strain levels are reached in suturing points, exceeding the physiological strain range and possibly leading to tissue laceration. FE analysis allows the optimization of the bioreactor configuration in order to ensure an efficient transduction of mechanical stimuli while preventing tissue damage. Full article

To foster a circular economy in line with compost quality assessment, a deep understanding of the fates of nutrients and carbon in the composting process is essential to achieve the co-benefits of value-added and environmentally friendly objectives. This paper is a review aiming to fill in the knowledge gap about the composting process. Firstly, a systematic screening search and a descriptive analysis were conducted on composting models involving the fates of Carbon (C), Nitrogen (N), Phosphorus (P) and Potassium (K) over the past decade, followed by the development of a checklist to define the gap between the existing models and target models. A review of 22 models in total led to the results that the mainstream models involved the fates of C and N, while only a few models involved P and K as target variables. Most of the models described the laboratory-scale composting process. Mechanism-derived models were relatively complex; however, the application of the fractionation of substrates could contribute to reducing the complexity. Alternatively, data-driven models can help us obtain more accurate predictions and involve the fates of more nutrients, depending on the data volume. Finally, the perspective of developing composting models for the fates of C, N, P, and K was proposed. Full article

This study proposes a reliable inline PAT concept for the simultaneous monitoring of different product components after chromatography. The feed for purification consisted of four main components, IgG monomer, dimer, and two lower molecular weight components of 4.4 kDa and 1 kDa molecular weight. The proposed measurement setup consists of a UV–VIS diode-array detector and a fluorescence detector. Applying this system, a R² of 0.93 for the target component, a R² of 0.67 for the dimer, a R² of 0.91 for the first side component and a R² of 0.93 for the second side component is achieved. Root mean square error for IgG monomer was 0.027 g/L, for dimer 0.0047 g/L, for side component 1 0.016 g/L and for the side component 2 0.014 g/L. The proposed measurement concept tracked component concentration reliably down to 0.05 g/L. Zero-point fluctuations were kept within a standard deviation of 0.018 g/L for samples with no IgG concentration but with side components present, allowing a reliable detection of the target component. The main reason inline concentration measurements have not been established yet, is the false-positive measurement of target components when side components are present. This problem was eliminated using the combination of fluorescence and UV–VIS data for the test system. The use of this measurement system is simulated for the test system, allowing an automatic fraction cut at 0.05 g/L. In this simulation a consistent yield of >99% was achieved. Process disturbances for processed feed volume, feed purity and feed IgG concentration can be compensated with this setup. Compared to a timed process control, yield can be increased by up to 12.5%, if unexpected process disturbances occur. Full article

The output generations of renewable energy sources (RES) depend basically on climatic conditions, which are the main reason for their uncertain nature. As a result, the performance and security of distribution systems can be significantly worsened with high RES penetration. To address these issues, an analytical study was carried out by considering different penetration strategies for RES in the radial distribution system. Moreover, a bi-stage procedure was proposed for optimal planning of RES penetration. The first stage was concerned with calculating the optimal RES locations and sites. This stage aimed to minimize the voltage variations in the distribution system. In turn, the second stage was concerned with obtaining the optimal setting of the voltage control devices to improve the voltage profile. The multi-objective cat swarm optimization (MO-CSO) algorithm was proposed to solve the bi-stages optimization problems for enhancing the distribution system performance. Furthermore, the impact of the RES penetration level and their uncertainty on a distribution system voltage were studied. The proposed method was tested on the IEEE 34-bus unbalanced distribution test system, which was analyzed using backward/forward sweep power flow for unbalanced radial distribution systems. The proposed method provided satisfactory results for increasing the penetration level of RES in unbalanced distribution networks. Full article

This work is aimed at providing a description of the complex world of drug carriers, starting from the description of this particular market in terms of revenue. Then, a brief overview of several types of conventional and innovative drug carrier systems has been included. The types of administration routes were also analyzed, with a critical and qualitative comment on drug release kinetics and drug profile shapes. Carriers were classified according to their ability to provide a prolonged and targeted release. The concept of the therapeutic window has been presented, providing advantages of having pulsed drug release to avoid side effects to target tissues. A critical comment on the use of conventional and innovative techniques for the production of drug carriers by large industrial companies has been proposed. As a final attempt for this work, an overall unique schematization of a drug carrier production process has been added, highlighting the necessity to create a strong double link among world-requested versatility of drug carriers for human applications and the newly developed industrial processes. Full article

Al-Mg-based composite is used in producing a variety of components. To improve the machinability of the composite, MoS₂ is added. For characterizing the machining of the Al-Mg-based composite, different wt.% (2, 4, and 6) of MoS₂ are added as reinforcement. Wire Electrical Discharge Machining (WEDM) process is performed to analyze the kerf width and surface roughness. Due to the complex nature of the WEDM process, the necessity for its optimization through the use of innovative methods is well-proven in the process of research. Evolutionary algorithms, specifically genetic algorithm based on NSGA-II and Multiple Objective Particle Swarm Optimization (MOPSO), are used for optimizing kerf width and surface roughness. For assessing the impact of current, pulse on time, and gap voltage on kerf width and surface roughness, an analysis of the selected WEDM process parameters is performed. MOPSO takes lesser iterations as compared to NSGA-II in giving nearly the same optimal fronts for achieving low kerf width and surface roughness. The 10–12 A of current, 50–57 µs of pulse on time, and 30–33 V of gap voltage are used for the WEDM process based on the Pareto-optimal solutions and better performance is achieved on the samples. In addition, the supplementary DOE method is applied to determine the relationship between factors affecting a process and the response. The analysis revealed that current has played a major part in the governance of kerf width and surface roughness over pulse on time and gap voltage for Al-Mg-MoS₂ composite. Full article

Agitated vessels (or mechanically stirred reactors) are heat exchange devices that are most widely used in many chemical and biochemical process industries, such as anaerobic digestion process. The mixing and heat transfer performances in these vessels are of crucial importance for increasing the energy efficiency in both batch and continuous processes. In this paper, a series of experiments were conducted to investigate heat transfer performance in agitated vessels for various configurations. In fact, this study examines the effects of heat transfer geometry (wall jacket and helical coils), heating power, and stirring speed, on the heating performance of two stirred fluids—water alone and a mixture of water and food waste. The experiments were conducted using a jacketed insulation tank with a helical coil and a propeller agitator. In each experiment, a transient method, based on measuring the temperature dependency on time, and solving the unsteady enthalpy balance, was used to determine the overall heat transfer coefficients between the agitated fluid and the heating surface. Finally, an extensive analysis of the reduced data was conducted based on temperature, heating time, heat transfer rate, heat transfer coefficient, and thermal resistance. The main finding was that the presence of food waste in agitated vessels reduces the heat rate of the agitated fluid with an average of 18.13% and 49.51%, respectively, for the case of JHX and CHX, and creates additional fouling, which further limits the heat transfer. Full article