Bioactive Composites for Bone Substitution

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Biological Processes and Systems".

Deadline for manuscript submissions: closed (15 February 2022) | Viewed by 2213

Special Issue Editor


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Guest Editor
Laboratoire de Physique de Clermont, CNRS/IN2P3, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France
Interests: new biomaterials for bone repair

Special Issue Information

Dear Colleagues,

There is an increased push to develop synthetic materials which can substitute bone tissues as an alternative to animal-derived substitutes. This Special Issue focuses on the various approaches to mimicking the hybrid architecture of bone or to achieving efficient bone regeneration through the development of bioactive composites. Here, bioactivity is intended as the ability to bond to bone tissues, promote bone regeneration or induce a targeted biological effect (e.g., antibacterial, angiogenic) through chemical or cellular actions. Bioceramics are materials demonstrating such a bioactivity, but their combination with a polymer matrix ultimately unveils their full potential by extending their mechanical properties and range of applications. Examples of the topics covered in this Special Issue include:

  • Organic–inorganic hybrids;
  • Bioceramics, silicates, bioactive glasses, and calcium-phosphate-based materials in combination with a polymer;
  • Materials doped with organic compounds of biological interest;
  • Polymers doped with inorganic compounds of biological interest;
  • Synthesis and characterization of these materials;
  • Soft chemistry routes to obtain bioactive composites or hybrids;
  • Scale-up of manufacturing processes from bench to pilot plants for these materials;
  • Biomedical, clinical, and commercial application of these materials;
  • Use of these materials in 3D printing, bioprinting, electrospinning, and other additive manufacturing techniques.

Prof. Dr. Jonathan Lao
Guest Editor

Manuscript Submission Information

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Keywords

  • bioceramics
  • bioactive glasses
  • hybrids
  • organic–inorganic materials
  • composites
  • polymer blends
  • calcium phosphates
  • silicates
  • doped
  • trace elements
  • polyphenols
  • flavonols
  • osteoinduction
  • antibacterial
  • angiogenic
  • 3D printing
  • bioprinting
  • scaffolds
  • sol–gel
  • soft chemistry

Published Papers (1 paper)

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Research

18 pages, 12124 KiB  
Article
Optimization of a Tricalcium Phosphate-Based Bone Model Using Cell-Sheet Technology to Simulate Bone Disorders
by Alexandra Damerau, Frank Buttgereit and Timo Gaber
Processes 2022, 10(3), 550; https://0-doi-org.brum.beds.ac.uk/10.3390/pr10030550 - 11 Mar 2022
Cited by 2 | Viewed by 1862
Abstract
Bone diseases such as osteoporosis, delayed or impaired bone healing, and osteoarthritis still represent a social, financial, and personal burden for affected patients and society. Fully humanized in vitro 3D models of cancellous bone tissue are needed to develop new treatment strategies and [...] Read more.
Bone diseases such as osteoporosis, delayed or impaired bone healing, and osteoarthritis still represent a social, financial, and personal burden for affected patients and society. Fully humanized in vitro 3D models of cancellous bone tissue are needed to develop new treatment strategies and meet patient-specific needs. Here, we demonstrate a successful cell-sheet-based process for optimized mesenchymal stromal cell (MSC) seeding on a β-tricalcium phosphate (TCP) scaffold to generate 3D models of cancellous bone tissue. Therefore, we seeded MSCs onto the β-TCP scaffold, induced osteogenic differentiation, and wrapped a single osteogenically induced MSC sheet around the pre-seeded scaffold. Comparing the wrapped with an unwrapped scaffold, we did not detect any differences in cell viability and structural integrity but a higher cell seeding rate with osteoid-like granular structures, an indicator of enhanced calcification. Finally, gene expression analysis showed a reduction in chondrogenic and adipogenic markers, but an increase in osteogenic markers in MSCs seeded on wrapped scaffolds. We conclude from these data that additional wrapping of pre-seeded scaffolds will provide a local niche that enhances osteogenic differentiation while repressing chondrogenic and adipogenic differentiation. This approach will eventually lead to optimized preclinical in vitro 3D models of cancellous bone tissue to develop new treatment strategies. Full article
(This article belongs to the Special Issue Bioactive Composites for Bone Substitution)
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