Special Issue "Secondary Metabolites: Extraction, Optimization, Identification and Applications in Food, Nutraceutical, and Pharmaceutical Industries"

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".

Deadline for manuscript submissions: 31 December 2021.
Related Special Issue: Phenolic Compounds: Extraction, Optimization, Identification and Applications in Food Industry

Special Issue Editor

Dr. Ibrahim M. Abu-Reidah
E-Mail Website
Guest Editor
1. Analytical Chemistry Department, Faculty of Sciences, University of Granada, Avenida. Fuentenueva s/n, 18071 Granada, Spain;
2. Memorial University of Newfoundland, St. John’s, NL A1B 3X5, Canada
Interests: phytochemicals; functional foods; natural products; plant biodiversity; medicinal plants; food plants; bioactivity; polyphenols; flavonoids; functional foods; secondary metabolite profiling
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit original articles to the Special Issue entitled “Secondary Metabolites: Extraction, Optimization, Identification, and Applications in Food, Nutraceutical, and Pharmaceutical Industries”.

Interest has grown around natural plant extracts in food and beverage applications, their role in food technology, quality, and their therapeutic use in inhibiting several diseases. The protecting effects of healthy diets rich in fruits, vegetables, and whole grains are due not only to fiber, vitamins, and minerals, but also to a diversity of plant secondary metabolites, in particular, phenolic compounds, which are considered among the most important classes originating in plant-derived secondary metabolites. Phenolic compounds are renowned for their possession of a wide array of remarkable biochemical and pharmacological properties, including antioxidant, antiviral, anticancer, and anti-inflammatory activities. Consequently, these compounds can be functional in the prevention of many diseases as well as in health maintenance, in addition to phenolic-varied applications in the nutraceutical, food, and pharmaceutical industries, and due to their importance in the pharma- and nutraceutical arenas. This Special Issue will gather the most recent contributions concerning their chemistry, extraction methods, and analytical techniques, along with their biological activities. The interpretation of phenolic bioactivities on a molecular basis by means of both well-established and advanced bio-analytical techniques is also welcome.

We would like to invite researchers to participate in this Special Issue by submitting a contribution in their field of expertise. Both original research papers and global or specialized critical reviews are welcome.

Potential topics include but are not limited to the following:

  • Advanced analytical methodologies for the isolation, purification, and analysis of phytochemicals from food, food wastes, and medicinal plants;
  • Phenolic compounds and metabolites in plants, food, and biological samples;
  • Biological activities and mechanisms of action;
  • Health benefits, in vivo evaluation;
  • Development of novel antioxidants and phenolic-based nutraceuticals and functional ingredients.

Dr. Ibrahim M. Abu-Reidah
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Phytochemical characterization
  • Pharmacological activity
  • Fingerprint
  • Secondary metabolites
  • Liquid and gas chromatographies
  • Mass spectrometry
  • Analytical methods
  • Phenolics
  • Bioactive compounds
  • Functional ingredients

Published Papers (3 papers)

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Research

Article
In Vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and In-Silico Study against β-Amyloid Precursor Protein
Processes 2021, 9(8), 1449; https://0-doi-org.brum.beds.ac.uk/10.3390/pr9081449 - 20 Aug 2021
Cited by 1 | Viewed by 606
Abstract
Medicinal plants possess a surplus of novel and biologically active secondary metabolites that are responsible for counteracting diseases. Traditionally, Gomphandra tetrandra (Wall.) Sleumer is used to treat mental disorders. The present research was designed to explore phytochemicals from the ethanol leaf extract of [...] Read more.
Medicinal plants possess a surplus of novel and biologically active secondary metabolites that are responsible for counteracting diseases. Traditionally, Gomphandra tetrandra (Wall.) Sleumer is used to treat mental disorders. The present research was designed to explore phytochemicals from the ethanol leaf extract of Gomphandra tetrandra (Wall.) Sleumer to identify the potential pharmacophore(s) in the treatment of neurological disorders. The chemical compounds of the experimental plant were identified through GC-MS analysis. In-vitro antioxidant activity was assessed using different methods. Furthermore, in-vivo neurological activity was assessed in Swiss-albino mice. Computer-aided analysis was appraised to determine the best-fit phytoconstituent of a total of fifteen identified compounds in the experimental plant extract against beta-amyloid precursor protein. The experimental extract revealed fifteen compounds in GC-MS analysis and the highest content was 9, 12, 15-octadecatrienoic acid (z,z,z). The extract showed potent antioxidant activity in in-vitro assays. Furthermore, in in-vivo neurological assays, the extract disclosed significant (p < 0.05) neurological activity. The most favorable phytochemicals as neurological agents were selected via ADMET profiling, and molecular docking was studied with beta-amyloid precursor protein. In the computer-aided study, 1, 5-diphenyl-2h-1, 2, 4-triazoline-3-thione (Pub Chem CID: 2802516) was more active than other identified compounds with strong binding affinity to beta-amyloid precursor protein. The present in vivo and in silico studies revealed neuropharmacological features of G. tetrandra leaf extract as a natural agent against neurological disorders, especially Alzheimer’s disease. Full article
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Article
PROMANCOA Modular Technology for the Valorization of Mango (Mangifera indica L.) and Cocoa (Theobroma cacao L.) Agricultural Biowastes
Processes 2021, 9(8), 1312; https://0-doi-org.brum.beds.ac.uk/10.3390/pr9081312 - 29 Jul 2021
Viewed by 366
Abstract
PROMANCOA modular technology (PMT) aims at the development of modular agricultural biowaste valorization of mango (Mangifera indica L.) and cocoa (Theobroma cacao L.) cultivars within the concept of circular economy in agriculture management. The modular design includes four modules: (1) green [...] Read more.
PROMANCOA modular technology (PMT) aims at the development of modular agricultural biowaste valorization of mango (Mangifera indica L.) and cocoa (Theobroma cacao L.) cultivars within the concept of circular economy in agriculture management. The modular design includes four modules: (1) green raw material (GRM) selection and collection, (2) GRM processing, (3) GRM extraction, in order to obtain bioactive green extracts (BGE) and bioactive green ingredients (BGI), and (4) quality control, which lead to formula components for food, feed, nutraceutical and/or cosmeceutical products. PMT was applied to mango stem bark and tree branches, and cocoa pod husk and bean shells, from cultivars of mango and cocoa in provinces of the Dominican Republic (DR). PMT might be applied to other agricultural biowastes, where a potential of value-added BGE/BGI may be present. Alongside the market potential of these bioactive ingredients, the reduction of carbon dioxide and methane emissions of agricultural biowastes would be a significant contribution in order to reduce the greenhouse effect of these residuals. Full article
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Article
UPLC-QToF Nanospray MS and NMR Analysis of Ficus sycomorus Stem Bark and Its Effects on Rabbit
Processes 2021, 9(7), 1201; https://0-doi-org.brum.beds.ac.uk/10.3390/pr9071201 - 12 Jul 2021
Viewed by 385
Abstract
In the present study, a phytochemical of Ficus sycomorus (Moraceae family) was screened, and the effect of this extract on rabbit performance indices, immunity, and carcass quality measures was determined. Ficus sycomorus samples were collected, air-dried, and extracted with 70% methanol to [...] Read more.
In the present study, a phytochemical of Ficus sycomorus (Moraceae family) was screened, and the effect of this extract on rabbit performance indices, immunity, and carcass quality measures was determined. Ficus sycomorus samples were collected, air-dried, and extracted with 70% methanol to prepare a solution of 100 mg/mL concentration. The extract was subjected to high-resolution mass spectrometric measurements via ultra-high performance liquid chromatography-quadrupole time-of-flight-nanospray mass spectrometry (UPLC-QToF-MS) and 1H NMR analysis. Forty-eight male rabbits, one-month-old, belonging to the Blanc de Bouscat and New Zealand White breeds were selected and distributed equally in a 2 × 3 factorial trial. The rabbits within each breed received F. sycomorus extract at the dose of 0, 100, and 200 mg/kg for 60 days. Blood samples were collected and serum obtained for the detection of liver enzymes, serum lipids, and proteins. The results of UPLC-QToF-MS and molecular networking analysis revealed the presence of procyanidin B2, procyanidin A1, genistein, eriodyctiol, catechin, luteolin, biochanin A, and chlorogenic acid that might exhibit various pharmaceutical activities. However, the F. sycomorus extract reduced rabbit performance indices and carcass quality measures. In addition, this extract significantly depressed the low-density lipoprotein and triglycerides, which may indicate the antidyslipidemia effect of this extract on rabbits. Full article
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