Special Issue "Construction of Heterocyclic Skeletons and Synthetic Process of Pharmaceutical Agents"

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".

Deadline for manuscript submissions: closed (30 September 2021).

Special Issue Editor

Prof. Dr. Yunfei Du
E-Mail Website
Guest Editor
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300000, China
Interests: medicinal chemistry; pharmaceutical science and technology; construction of heterocyclic compounds and pharmaceutical agents; hypervalent iodine;

Special Issue Information

Dear Colleagues,

Heterocyclic skeletons are highly ubiquitous structural units in organic compounds, especially in biologically active natural products such as alkaloids, flavonoids, quinones, and glycosides. Furthermore, these biologically interesting skeletons such as indole, oxazole, and imidazole are also widely found in various pharmaceutical agents. Accordingly, the development of novel synthetic methods for the construction of heterocyclic skeletons has been an everlasting hotspot in the field of organic synthesis, and the search for optimal synthesis processes to access these heterocyclic pharmaceutical agents, their intermediates, or their precursors has also attracted extensive attention from both organic and medicinal chemists. As the past several decades have witnessed tremendous growth in developing various novel synthetic concepts, strategies, approaches, and technologies in organic synthesis, there has emerged a plethora of efficient methodologies, especially the “green” approaches for the synthesis of heterocyclic compounds (including naturally occurring compounds) and pharmaceutical agents.

This Special Issue entitled “Construction of Heterocyclic Skeletons and Synthesis Process of Pharmaceutical Agents” aims to collect research related to the development of novel synthetic methodologies for the construction of heterocyclic skeletons and the provision of alternative synthetic routes to access pharmaceutical agents. Topics include but are not limited to the following:

  • Novel or enhanced strategies for the construction of heterocyclic skeletons;
  • Total synthesis of naturally occurring compounds containing a heterocyclic skeleton;
  • Alternative methods for synthesizing drug molecules or their intermediates based on improved reactions;
  • Synthesis process studies for the production of pharmaceutical agents or their intermediates;
  • Application of novel heterocyclic skeletons in drug discovery;
  • Mechanistic studies associated with the above methodologies.

Prof. Dr. Yunfei Du
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Heterocyclic skeleton
  • Naturally occurring compound
  • Synthetic method
  • Drug molecule
  • Synthesis process
  • Pharmaceutical agents
  • Drug discovery
  • Mechanistic studies

Published Papers

There is no accepted submissions to this special issue at this moment.
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