Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.7
3.5
Journals
Processes
Special Issues
Design and Preparation of Pharmaceutical Formulation
share announcement

Design and Preparation of Pharmaceutical Formulation

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".

Deadline for manuscript submissions: closed (20 March 2022) | Viewed by 2947

Special Issue Editor

Prof. Dr. Tzung-Han Chou

E-Mail Website
Guest Editor
Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Yunlin 64002, Taiwan
Interests: drug formulation design; drug formulation preparation; physicochemical characteristics of drug formulations; drug formulation performance; drug formulation development

Special Issue Information

Dear Colleagues,

Many drugs have been developed for the numerous diseases that occur in humans.  However, most drugs typically face two problems—biocompatibility and bio-availability—in clinical cases. To solve such problems and to maximize therapeutic effects, drug formulation development is necessary.

The Special Issue, Design and Preparation of Pharmaceutical Formulation, aims to publish articles in the rapidly developing area of smart drug delivery systems.  The scope of the issue covers topics related to colloidal carriers for drug delivery, such as liposomes, vesicles, emulsions, micelles, nanoparticles, and nano-emulsions, and other smart assembly systems for the improvement in drug delivery. This Special Issue is focused on manufacturing parameters and formulation variables that affect the performance of drug delivery systems. It is our pleasure to invite you submit a new manuscript to this Special Issue. Full papers, communications and reviews are welcome.

Prof. Dr. Tzung-Han Chou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • formulation design and preparation
  • physicochemical characteristics of drug formulations
  • manufacturing parameters
  • drug encapsulation and drug release
  • in vitro bioassay

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

24 pages, 7196 KiB  
Article
Polyethylenimine/cGAMP Nanocomplexes for STING-Mediated Cancer Immunotherapy: Formulation and Characterization Using Orthogonal Techniques
by Marija Petrovic, Gerrit Borchard and Olivier Jordan
Processes 2022, 10(5), 882; https://0-doi-org.brum.beds.ac.uk/10.3390/pr10050882 - 29 Apr 2022
Cited by 3 | Viewed by 1741
Abstract
Cyclic GMP-AMP (cGAMP) has lately been extensively investigated in cancer immunotherapy due its activation of the innate immunity stimulation of interferon genes (STING) pathway within antigen presenting cells (APC) leading to an increase in tumor specific CD8+ T cells. As negatively charged dinucleotides [...] Read more.
Cyclic GMP-AMP (cGAMP) has lately been extensively investigated in cancer immunotherapy due its activation of the innate immunity stimulation of interferon genes (STING) pathway within antigen presenting cells (APC) leading to an increase in tumor specific CD8+ T cells. As negatively charged dinucleotides are prone to enzymatic degradation before being taken up by APC, there is a need for an appropriate carrier. Therefore, polyethylenimine (PEI), a gold standard for oligonucleotide delivery, was selected. Molecular weight, type of PEI and N/P ratio between PEI/cGAMP were investigated in terms of toxicity, efficacy and physicochemical properties of the nanocomplexes (NCs) such as size, zeta potential and shape. Due to lack of nano-medicine regulations and the need for a case-by case assessment, here we examine these parameters by several orthogonal methods, such as dynamic light scattering (DLS), nanoparticle tracking analysis (NTA) and online asymmetric flow field flow fractionation (AF4) connected to DLS. N/P ratio of 2/1 ratio using linear PEI 25 kDa resulted in larger, positively charged particles of elongated shape, which were shown to have the best toxicity/efficacy ratio among different PEIs and ratios tested. Full article
(This article belongs to the Special Issue Design and Preparation of Pharmaceutical Formulation)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop