Does Atherosclerosis Begin in Childhood?
A special issue of Reports (ISSN 2571-841X).
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 513
Special Issue Editor
Interests: growth hormone; growth hormone receptor; IGF-I; brain injury; stroke; cerebral palsy; hypoxia/ischemia; neurodegeneration; atherosclerosis; growth hormone and gonads; growth hormone and diabetes; growth hormone and cancer; growth hormone signaling pathway
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Special Issue Information
Dear Colleagues,
Many years ago, American forensic doctors who performed autopsies on young soldiers who died in the Vietnam War were surprised to see that at such an early age, many of those young people presented a high number of atherosclerotic plaques. Today we know that the development of the atheromatous plaque is a multifactorial process in which inflammation plays a very important role. The key aspect of the plaque formation is the endothelial dysfunction secondary to some atherogenic stimuli, such as hypercholesterolemia, hypertension, diabetes, but also bad nutritional habits.
In this sense, the WHO a few years ago warned that the first world population consumed an excess of Omega 6 fatty acids in relation to Omega 3 (50:1 ratio, when at most it should be 5:1). This abnormal ratio leads to a permanent inflammatory condition. This is particularly marked in children due to the eating habits they present. The resulting inflammation leads to mitochondrial dysfunction increasing the production of reactive oxygen species (ROS), and endothelial dysfunction. Therefore, it is not unreasonable to think that the development of atheromatous plaques can already begin in childhood. The consequences of it would be the appearance, in the medium or long term, of cardiovascular diseases: arterial occlusions leading to myocardial infarction, or stroke, or claudication or critical limb ischemia.
In order to clarify whether this hypothesis is correct, this Special Issue will collect manuscripts related to this topic.
Prof. Dr. Jesús Devesa
Guest Editor
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