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Reprod. Med.
Special Issues
Advances in Fetal Medicine
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Advances in Fetal Medicine

A special issue of Reproductive Medicine (ISSN 2673-3897).

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 11840

Special Issue Editors

Dr. Paolo Ivo Cavoretto

E-Mail Website
Guest Editor
IRCCS San Raffaele Hospital and University, Via Olgettina 62, 20132 Milan, Italy
Interests: obstetrics; pregnancy complications; ultrasound; Doppler; fetal medicine and surgery; MRI; screening in pregnancy; congenital malformations; congenital heart defects; open spina bifida; fetal growth; preterm delivery; preeclampsia; pregnancy after medically assisted reproduction
Special Issues, Collections and Topics in MDPI journals
Dr. Anca Maria Panaitescu

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 010164 Bucharest, Romania
Interests: fetal cardiac disease; coronavirus; cytomegalovirus; coxsackievirus; Toxoplasma gondii; flu viruses; HIV; rubella virus; Streptococcus; parvovirus B19; herpes virus
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of fetal medicine is evolving rapidly, and it has a major contribution to modern obstetrics. From fetal anomalies with planned intrauterine or postnatal surgery, to screening for complications of pregnancy such as pre-eclampsia, fetal growth restriction and preterm birth, most fetal diagnoses present relevant implications and benefits of timely preventive interventions. As a result, advances in fetal medicine determined a major contribution to improving maternal and infant outcomes.

The aim of this Special Issue of Reproductive Medicine is to explore current advances in the field of fetal medicine including early diagnosis of fetal abnormalities, screening and diagnosis of chromosomal defects and genetic syndromes, intrauterine treatment and surgery, placental anomalies, screening and interventions to prevent preeclampsia, fetal growth restriction, stillbirth, preterm delivery and management of obstetric problems of multiple pregnancies, assisted reproductive techniques and maternal disease. Submission of unpublished original studies are welcome, including fundamental and clinical research studies, observational and interventional studies, randomised controlled trials and reviews, with an emphasis on relevant clinical questions and quantitative syntheses (meta-analyses) of pooled data. Authors are invited to contact the Editorial Team in advance if they require assistance for the preparation of their manuscript.

Dr. Paolo Ivo Cavoretto
Dr. Anca Panaitescu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Reproductive Medicine is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Early fetal diagnosis
  • Intrauterine fetal treatment
  • Medical complications of pregnancy
  • Multiple pregnancy
  • Genetic diagnosis
  • Early pregnancy ultrasound scan
  • Obstetric ultrasound
  • Fetal MRI

Published Papers (2 papers)

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6 pages, 657 KiB  
Case Report
Recurrent Congenital Heart Block Due to Maternal Anti-Ro Antibodies: Successful Prevention of Poor Pregnancy Outcome with Hydroxychloroquine and Added Dexamethasone
by Brindusa Cimpoca-Raptis, Anca Marina Ciobanu, Nicolae Gica, Ana Maria Scutelnicu, Alexandra Bouariu, Mihaela Popescu and Anca Maria Panaitescu
Reprod. Med. 2022, 3(1), 36-41; https://0-doi-org.brum.beds.ac.uk/10.3390/reprodmed3010004 - 14 Feb 2022
Cited by 1 | Viewed by 4674
Abstract
Autoimmune Congenital Heart Block (CHB) is an immune-mediated disease caused by transplacental passage of maternal circulating anti-Ro/SSA and anti-La/SSB antibodies which can bind to fetal cardiac tissue, damaging conduction tissues by inflammation and fibrosis. Approximately 2% of pregnancies with positive anti-Ro antibodies will [...] Read more.
Autoimmune Congenital Heart Block (CHB) is an immune-mediated disease caused by transplacental passage of maternal circulating anti-Ro/SSA and anti-La/SSB antibodies which can bind to fetal cardiac tissue, damaging conduction tissues by inflammation and fibrosis. Approximately 2% of pregnancies with positive anti-Ro antibodies will be complicated by fetal atrioventricular block and the risk of recurrence in subsequent pregnancies is 10 times higher. We report a case of a clinically asymptomatic patient diagnosed with anti-Ro antibodies who had two pregnancies complicated by CHB with different outcomes. Despite preventive treatment with hydroxychloroquine (HCQ) from 6 weeks of pregnancy onward, the fetus developed second to third degree CHB. Dexamethasone was added. The pregnancy evolved to near-term with persistent intermittent CHB. It is not clear how pregnancies with recurrent fetal CHB despite prophylaxis with HCQ should be managed and there is a need for controlled studies to answer the remaining questions in relation to this subject. Full article
(This article belongs to the Special Issue Advances in Fetal Medicine)
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8 pages, 11857 KiB  
Case Report
Prenatal Diagnosis of Severe Fetal Hydronephrosis Due to Pyeloureteral Junction Syndrome with False Neonatal Resolution
by Gerarda Gaeta, Mirko Pozzoni, Audrey Serafini, Arianna Lesma, Pier Luigi Paesano, Massimo Candiani and Paolo Ivo Cavoretto
Reprod. Med. 2021, 2(4), 163-170; https://0-doi-org.brum.beds.ac.uk/10.3390/reprodmed2040017 - 15 Nov 2021
Cited by 2 | Viewed by 5747
Abstract
A case of severe fetal hydronephrosis due to isolated bilateral stenosis of the pyelo-ureteral junction was diagnosed at our centre. Surprisingly, a negative renal ultrasound scan was performed on the 3rd postnatal day. An ultrasound follow-up showed severe bilateral pyelectasis a few weeks [...] Read more.
A case of severe fetal hydronephrosis due to isolated bilateral stenosis of the pyelo-ureteral junction was diagnosed at our centre. Surprisingly, a negative renal ultrasound scan was performed on the 3rd postnatal day. An ultrasound follow-up showed severe bilateral pyelectasis a few weeks later. The infant underwent bilateral pyeloplasty at six months of age with an excellent outcome. Such a neonatal picture may be due to the reduction of urinary output secondary to excessive postnatal weight loss and dehydration. In this case, prenatal ultrasound result was more reliable than postnatal ultrasound, emphasizing the importance of postnatal urologic follow-up after prenatal indication. Full article
(This article belongs to the Special Issue Advances in Fetal Medicine)
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