Research Progress of Diabetes Mellitus

A special issue of Sci (ISSN 2413-4155). This special issue belongs to the section "Biology Research and Life Sciences".

Deadline for manuscript submissions: closed (30 March 2022) | Viewed by 3563

Special Issue Editor


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Guest Editor
School of Medical and Health Science. Edith Cowan University, Perth, Australia
Interests: diabetes; genetics; complications of diabetes

Special Issue Information

Dear Colleagues,

Diabetes is a global health crisis that has rapidly increased in past decades, leading to an increase in mortality, morbidity and healthcare. The health-related increase has arisen due to diabetic complications which are frequent in diabetic patients and over time damage the heart, blood vessels, eyes, kidneys and nerves, and increase the risk of heart disease and stroke, where many have more than one of these complications (Global report on Diabetes WHO, 2016). This damage is primarily due to a complex metabolic disease characterised by extended high levels of blood glucose (WHO Guidelines Approved by the Guidelines Review Committee, 2011).

The Special Issue invites original research papers to address research progress in diabetes mellitus, covering, but not limited to, genetics and genetic risk factors, insulin action, beta cell function, insulin-producing beta cells and/or transplantation, nutrition and environmental links to diabetes.  

Potential topics include, but are not limited to:

  • Type one Diabetes Mellitus;
  • Type two Diabetes Mellitus;
  • Diabetic complications;
  • Genetics of diabetes;
  • Insulin producing cells;
  • Insulin;
  • Glucose;
  • Pancreas;
  • Autoimmune;
  • Juvenile diabetes;
  • Maturity onset diabetes of the young;
  • Neonatal diabetes mellitus;
  • Suboptimal health Status;
  • Monogenic diabetes;
  • Monogenic diabetes mutations;
  • Metabolic disease;
  • Hormone;
  • Animal models of diabetic complications;
  • Glycans and lipids;
  • Metabolic syndrome.

Dr. Lois Balmer
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sci is an international peer-reviewed open access quarterly journal published by MDPI.

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Keywords

  • type one diabetes mellitus
  • type two diabetes mellitus
  • diabetic complications
  • genetics of diabetes
  • maturity onset diabetes of the young
  • animal models of diabetic complications
  • suboptimal health status

Published Papers (1 paper)

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Research

13 pages, 287 KiB  
Article
Association between Transcription Factor 7-like-2 Polymorphisms and Type 2 Diabetes Mellitus in a Ghanaian Population
by Christian Obirikorang, Evans Asamoah Adu, Enoch Odame Anto, Emmanuel Acheampong, Lawrence Quaye, Brodrick Yeboah Amoah, Max Efui Annani-Akollor, Aaron Siaw Kwakye, Foster Fokuoh, Michael Appiah, Eric Nana Yaw Nyarko, Freeman Aidoo, Eric Adua, Ebenezer Afrifa-Yamoah, Lois Balmer and Wei Wang
Sci 2021, 3(4), 40; https://0-doi-org.brum.beds.ac.uk/10.3390/sci3040040 - 05 Nov 2021
Viewed by 2861
Abstract
Type 2 diabetes mellitus (T2DM) has been strongly associated with single nucleotide polymorphisms (SNPs) in the TCF7L2 gene. This study investigated the association between rs12255372, rs7903146 in the TCF7L2 gene and T2DM in a Ghanaian population. A case-control study design was used for [...] Read more.
Type 2 diabetes mellitus (T2DM) has been strongly associated with single nucleotide polymorphisms (SNPs) in the TCF7L2 gene. This study investigated the association between rs12255372, rs7903146 in the TCF7L2 gene and T2DM in a Ghanaian population. A case-control study design was used for this study. A total of 106 T2DM patients and 110 control participants were selected. Basic data collected included body mass index, blood pressure and socio-demographics. Fasting blood samples were collected and processed for: serum lipid analysis, plasma glucose estimation and plasma HbA1c estimation. Parts of the whole blood samples were used for DNA extraction using a modified salting-out method. Common and allele-specific primers were designed for genotyping using the Modified Tetra-Primer Amplification assay. Associations were evaluated using logistic regression models. The rs7903146 risk variant was significantly associated with 2.16 vs. 4.06 increased odds for T2DM in patients <60 years vs. ≥60 years. Both rs7903146 and rs12255372 were significantly associated with increased odds of T2DM in women, overweight/obese, T2DM negative family history (T2DM-NFH) and low-HDL-C. In a multivariate model, rs7903146 but not rs12255372 was significantly associated with 2.18, 5.01 and 2.25 increased odds of T2DM, under the codominant, recessive and additive model, respectively (p < 0.05). The association between rs7903146 and rs12255372 with T2DM is more highly associated in a subgroup—women and those with T2DM-NFH, yet who have cardiometabolic risk. Full article
(This article belongs to the Special Issue Research Progress of Diabetes Mellitus)
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