Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.9
2.7
Journals
Symmetry
Special Issues
Brain Asymmetry in Evolution II
share announcement

Brain Asymmetry in Evolution II

A special issue of Symmetry (ISSN 2073-8994). This special issue belongs to the section "Life Sciences".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 5725

Special Issue Editor

Prof. Dr. Kazuhiko Sawada

E-Mail Website
Guest Editor
Department of Nurtrition, Tsukuba International University, Tuchiura, Japan
Interests: phylogeny and evolution of the brain
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Asymmetric development of the brain structure and function is a species-related unique feature in vertebrates and is often involved in the complex neuronal networks connecting the left and right sides of the brain. Structural and functional lateralization is obvious particularly in the cerebral cortex of higher mammals such as primates and carnivores and associated with cognition, emotion, language, preference of hand/paw use, despite its appearance with high individual variability. Notably, the lateralized morphology and/or function of the brain are frequently disturbed in psychological and neurodevelopmental disorders in humans such as autism, schizophrenia, dyslexia, attention deficit hyperactivity disorder, and specific language impairments. The purpose of this Special Issue on “Brain Asymmetry in Evolution 2” is to focus on species-related unique asymmetric features of the brain structures and function, which are essential for understanding the evolution of the brain. In this issue, we are also interested in the sexual dimorphism of brain asymmetry, brain function in relevant to motor and behavioral lateralization, and altered brain asymmetry in diseases and/or gene manipulations. We welcome research papers, short communication, and comprehensive reviews. We also welcome descriptive studies and case reports if they have the potential to lead to new insights or hypotheses in future research.

Prof. Dr. Kazuhiko Sawada
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Symmetry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cerebrum
  • Cerebellum
  • Cognition
  • Social deficits
  • Language lateralization
  • Handedness
  • Motor lateralization
  • Behavioral lateralization
  • Autism
  • Schizophrenia

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

8 pages, 857 KiB  
Article
Sex-Related Left-Lateralized Development of the Crus II Region of the Ansiform Lobule in Cynomolgus Monkeys
by Kazuhiko Sawada and Shigeyoshi Saito
Symmetry 2022, 14(5), 1015; https://0-doi-org.brum.beds.ac.uk/10.3390/sym14051015 - 16 May 2022
Cited by 2 | Viewed by 1516
Abstract
The asymmetric development of the cerebellum has been reported in several mammalian species. The current study quantitatively characterized cerebellar asymmetry and sexual dimorphism in cynomolgus macaques using magnetic resonance (MR) imaging-based volumetry. Three-dimensional T1W MR images at 7-tesla were acquired ex [...] Read more.
The asymmetric development of the cerebellum has been reported in several mammalian species. The current study quantitatively characterized cerebellar asymmetry and sexual dimorphism in cynomolgus macaques using magnetic resonance (MR) imaging-based volumetry. Three-dimensional T1W MR images at 7-tesla were acquired ex vivo from fixed adult male (n = 5) and female (n = 5) monkey brains. Five transverse domains of the cerebellar cortex, known as cerebellar compartmentation defined by the zebrin II/aldolase expression pattern, were segmented on MR images, and the left and right sides of their volumes were calculated. Asymmetry quotient (AQ) analysis revealed significant left-lateralization at the population level in the central zone posterior to the cerebellar transverse domains, which included lobule VII of the vermis with the crura I and II of ansiform lobules, in males but not females. Next, the volume of the cerebellar hemispherical lobules was calculated. Population-level leftward asymmetry was revealed in the crus II regions in males using AQ analysis. The AQ values of the other hemispherical lobules showed no left/right side differences at the population level in either sex. The present findings suggest a sexually dimorphic asymmetric aspect of the cerebellum in cynomolgus macaques, characterized by a leftward lateralization of the crus II region in males, but no left/right bias in females. Full article
(This article belongs to the Special Issue Brain Asymmetry in Evolution II)
►▼ Show Figures

Figure 1

9 pages, 2553 KiB  
Article
Asymmetry Index Evaluation of Cerebral Volume and Cerebral Blood Flow in Neonatal Hypoxic–Ischemic Encephalopathy
by Natsuo Banura, Akiko Ohki and Shigeyoshi Saito
Symmetry 2022, 14(3), 596; https://0-doi-org.brum.beds.ac.uk/10.3390/sym14030596 - 17 Mar 2022
Viewed by 1321
Abstract
The aim of the present study was to longitudinally evaluate the differences in cerebral volume and cerebral blood flow (CBF) on the right and left sides in rats with neonatal hypoxic–ischemic encephalopathy (HIE) using magnetic resonance imaging and the Rice–Vannucci model. Unilateral ligation [...] Read more.
The aim of the present study was to longitudinally evaluate the differences in cerebral volume and cerebral blood flow (CBF) on the right and left sides in rats with neonatal hypoxic–ischemic encephalopathy (HIE) using magnetic resonance imaging and the Rice–Vannucci model. Unilateral ligation of the left common carotid artery was performed on 8-day-old rats, followed by mild (1 h, n = 6) or severe (2 h, n = 7) hypoxic exposure. T2-weighted (T2W) and CBF images were obtained at 1 h and 1, 3, and 7 days following the HI insult. The cerebral volume (Vlesion and Vcontrol), CBF in both hemispheres (lesion and control sides), and asymmetry indices of the cerebral volume (AIvolume) and CBF (AICBF) were calculated for each group. Slight hyperintensities were noted in the lesion-side hemispheres on T2W images at 1 h and 1 day in both groups, as were pronounced hyperintensities at days 3 and 7 in the severe group. AIvolume was positive (Vlesion > Vcontrol) in the mild and severe groups until days 1 and 3, respectively, and changed to negative on days 3 and 7 in the mild and severe groups. These results suggest that the prolonged positive AIvolume prior to day 3 in the severe group was caused by long-term cell swelling following severe HI insult. Full article
(This article belongs to the Special Issue Brain Asymmetry in Evolution II)
►▼ Show Figures

Graphical abstract

14 pages, 3735 KiB  
Article
Longitudinal Observation of Asymmetric Iron Deposition in an Intracerebral Hemorrhage Model Using Quantitative Susceptibility Mapping
by Keiho Tsuji, Ryutarou Onishi, Reika Sawaya, Narumi Arihara, Junpei Ueda and Shigeyoshi Saito
Symmetry 2022, 14(2), 350; https://0-doi-org.brum.beds.ac.uk/10.3390/sym14020350 - 09 Feb 2022
Viewed by 2349
Abstract
Quantitative susceptibility mapping (QSM) is used to obtain quantitative magnetic susceptibility maps of materials from magnitude and phase images acquired by three-dimensional gradient-echo using inverse problem-solving. Few preclinical studies have evaluated the intracerebral hemorrhage (ICH) model and asymmetric iron deposition. We created a [...] Read more.
Quantitative susceptibility mapping (QSM) is used to obtain quantitative magnetic susceptibility maps of materials from magnitude and phase images acquired by three-dimensional gradient-echo using inverse problem-solving. Few preclinical studies have evaluated the intracerebral hemorrhage (ICH) model and asymmetric iron deposition. We created a rat model of ICH and compared QSM and conventional magnetic resonance imaging (MRI) during the longitudinal evaluation of ICH. Collagenase was injected in the right striatum of 12-week-old Wistar rats. QSM and conventional MRI were performed on days 0, 1, 7, and 28 after surgery using 7-Tesla MRI. Susceptibility, normalized signal value, and area of the hemorrhage site were statistically compared during image analysis. Susceptibility decreased monotonically up to day 7 but increased on day 28. Other imaging methods showed a significant increase in signal from day 0 to day 1 but a decreasing trend after day 1. During the area evaluation, conventional MRI methods showed an increase from day 0 to day 1; however, decreases were observed thereafter. QSM showed a significant increase from day 0 to day 1. The temporal evaluation of ICH by QSM suggested the possibility of detecting of asymmetric iron deposition for normal brain site. Full article
(This article belongs to the Special Issue Brain Asymmetry in Evolution II)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop