Dear Colleagues,

I have been engaged for many years in the synthesis and photochemical evaluation of photosensitive ‘caged’ compounds as tools for neurophysiological investigations. I have also been involved in the synthesis and application of chemical ligation auxiliaries for their effectiveness in solid-phase peptide synthesis. The scope of the work was not only to develop new technologies but also to improve existing tools for the synthesis of biologically useful proteins and other biomolecules. More recently my research has been focused in the design and synthesis of a variety of small molecules as tools for biomedical research, ranging from modified amino acids, heterocyclic compounds, labelled nucleosides, fluorescent probes for use as enzyme inhibitors or detectors, or as cross linkers in structural studies. Particularly synthesis of inhibitory compounds with potential to be developed as new types of antimalarial drugs or to study the role of Wnt signaling in tissue homeostasis or to study how the Wnt pathway is regulated in intestinal stem cell and cancer.

Please note that all submitted papers must be within the general scope of the Symmetry journal.

Dr. George Papageorgiou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Symmetry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• photolabile biomolecules
• chemical ligation auxiliaries
• biosensor synthesis
• neuroactive amino acids and peptides
• new antimalarial and cancer drugs