Dear colleagues,

Invertebrates represent the vast majority of all known animal species, inhabiting multiple habitats of the planet. Moreover, they perform key roles in various ecosystem functions. With the exception of the imposex phenomenon in gastropods, that is indisputably associated with organotin exposure and has received large attention in recent decades, most research in the field of endocrine-disrupting chemicals has focused on vertebrates. This is mostly related to the lack of knowledge of invertebrate endocrinology and available genomic resources. However, the full genome and transcriptome projects conducted for most invertebrate taxa over the past decade have brought about an unprecedent tool for addressing the hazard assessment of endocrine-disrupting chemicals in invertebrates. Several examples indisputably demonstrate that the genomic constitution of a given species is a key aspect that determines its response towards chemical insults. Therefore, disclosing the molecular constitution of different taxa is fundamental to understanding the mode of action (MoA) of environmental pollutants. Understanding the MoA of environmental chemicals allows the building of a toxicant response, thus becoming a central piece of hazard assessment.

For this Special Issue, we invite high-quality original research papers, short communications, and reviews focusing on all aspects of hazard assessment of endocrine-disrupting chemicals in invertebrates. Studies may be in vivo, in vitro, and in silico studies including both field and laboratory approaches. Research on single chemicals, mixtures, and complex environmental samples are welcome. We also welcome computational or predictive studies.

Prof. Dr. Miguel Machado Santos
Dr. Luís Filipe C. Castro
Dr. Teresa Neuparth
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• mode of action
• invertebrate tax
• endocrine-disrupting chemical
• hazard assessment
• toxicity testing